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Cancer Research

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Mitochondrial metabolism fueled by FAO alters the membrane composition and introduces membrane fragility upon cold exposure in OxPhos-driven AML and in LSCs.

Unraveling the trajectories of preexisting resistant and drug-tolerant persister cells facilitates the rational design of multidrug combination or sequential therapies, presenting an approach to explore for treating EGFR-mutant lung cancer.

Cancer Biology

Dysfunction of the Polycomb component RYBP in combination with loss of 5-methylcytosine oxidases promotes widespread hypermethylation of CpG islands in bronchial cells and induces tumorigenesis, resembling changes seen in human lung tumors.

A micropeptide encoded by lncRNA AC115619 impedes formation of the m6A methylation complex to lower m6A levels and reduce the growth of hepatocellular carcinoma.

Cancer Immunology

PTEN loss leads to development of an immunosuppressive microenvironment in lung cancer that confers resistance to anti–PD-1 therapy, which can be overcome by targeting PTEN loss–mediated immunosuppression.

PP2Ac deficiency promotes cGAS–STING signaling in glioma to induce a tumor-suppressive immune microenvironment, highlighting PP2Ac as a potential therapeutic target to enhance tumor immunogenicity and improve response to immunotherapy.

Therapeutic Development and Chemical Biology

Targeting the proteasome in combination with MDM2 inhibition activates the ATF4/CHOP stress response axis to induce apoptosis in liposarcoma, providing a potential therapeutic approach for the most common soft–tissue sarcoma.

Translational Cancer Biology

Functional analysis of the impact of a large number of missense variants on RAD51C function provides insight into RAD51C activity and information for classification of the cancer relevance of RAD51C variants.

Elom K. Aglago; Andre Kim; Yi Lin; Conghui Qu; Marina Evangelou; Yu Ren; John Morrison; Demetrius Albanes; Volker Arndt; Elizabeth L. Barry; James W. Baurley; Sonja I. Berndt; Stephanie A. Bien; D. Timothy Bishop; Emmanouil Bouras; Hermann Brenner; Daniel D. Buchanan; Arif Budiarto; Robert Carreras-Torres; Graham Casey; Tjeng Wawan Cenggoro; Andrew T. Chan; Jenny Chang-Claude; Xuechen Chen; David V. Conti; Matthew Devall; Virginia Diez-Obrero; Niki Dimou; David Drew; Jane C. Figueiredo; Steven Gallinger; Graham G. Giles; Stephen B. Gruber; Andrea Gsur; Marc J. Gunter; Heather Hampel; Sophia Harlid; Akihisa Hidaka; Tabitha A. Harrison; Michael Hoffmeister; Jeroen R. Huyghe; Mark A. Jenkins; Kristina Jordahl; Amit D. Joshi; Eric S. Kawaguchi; Temitope O. Keku; Anshul Kundaje; Susanna C. Larsson; Loic Le Marchand; Juan Pablo Lewinger; Li Li; Brigid M. Lynch; Bharuno Mahesworo; Marko Mandic; Mireia Obón-Santacana; Victor Moreno; Neil Murphy; Hongmei Nan; Rami Nassir; Polly A. Newcomb; Shuji Ogino; Jennifer Ose; Rish K. Pai; Julie R. Palmer; Nikos Papadimitriou; Bens Pardamean; Anita R. Peoples; Elizabeth A. Platz; John D. Potter; Ross L. Prentice; Gad Rennert; Edward Ruiz-Narvaez; Lori C. Sakoda; Peter C. Scacheri; Stephanie L. Schmit; Robert E. Schoen; Anna Shcherbina; Martha L. Slattery; Mariana C. Stern; Yu-Ru Su; Catherine M. Tangen; Stephen N. Thibodeau; Duncan C. Thomas; Yu Tian; Cornelia M. Ulrich; Franzel JB van Duijnhoven; Bethany Van Guelpen; Kala Visvanathan; Pavel Vodicka; Jun Wang; Emily White; Alicja Wolk; Michael O. Woods; Anna H. Wu; Natalia Zemlianskaia; Li Hsu; W. James Gauderman; Ulrike Peters; Konstantinos K. Tsilidis; Peter T. Campbell

This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.

Cancer Landscapes

Analysis of epigenetic and transcriptional changes in a transformation model reveals that transposable element expression and methylation are dysregulated during oncogenic transformation.

Convergence Science

Comprehensive characterization of genomic and transcriptomic alterations in breast tumors from Hispanic/Latina patients reveals distinct genetic alterations and signatures, demonstrating the importance of inclusive studies to ensure equitable care for patients.

BRCA1 deficiency generates an acidic microenvironment to promote cancer metastasis and immunotherapy resistance that can be reversed using a sialyltransferase inhibitor.

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