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15 April 2022
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Cover Image
Cover Image
Intrahepatic cholangiocarcinoma (ICC) arises from the bile ducts within the liver and is characterized by high levels of genetic heterogeneity. Younger and colleagues performed a functional in vivo study into the role genetic heterogeneity plays in driving ICC. The cover image depicts lineage traced cells (red) with Trp53 and Pten deletion in the liver bile duct stained for Keratin-19 (cyan), which generate ICC when exposed to inflammation. For details, see the article by Younger and colleagues on page 1548. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Cancer Research
Table of Contents
Breaking Insights
Reviews
Understanding Drug Sensitivity and Tackling Resistance in Cancer
Jeffrey W. Tyner; Franziska Haderk; Anbarasu Kumaraswamy; Linda B. Baughn; Brian Van Ness; Song Liu; Himangi Marathe; Joshi J. Alumkal; Trever G. Bivona; Keith Syson Chan; Brian J. Druker; Alan D. Hutson; Peter S. Nelson; Charles L. Sawyers; Christopher D. Willey; for the Drug Resistance and Sensitivity Network
Cancer Research Landmarks
Cancer Research Highlights
Controversy and Consensus
Genome and Epigenome
Structure, Dynamics, and Impact of Replication Stress–Induced Structural Variants in Hepatocellular Carcinoma
Quentin Bayard; Pierre Cordier; Camille Péneau; Sandrine Imbeaud; Theo Z. Hirsch; Victor Renault; Jean-Charles Nault; Jean-Frédéric Blanc; Julien Calderaro; Chantal Desdouets; Jessica Zucman-Rossi; Eric Letouzé
Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution
Xiansong Wang; Wei Hu; Xiangchun Li; Dan Huang; Qing Li; Hung Chan; Judeng Zeng; Chuan Xie; Huarong Chen; Xiaodong Liu; Tony Gin; Maggie Haitian Wang; Alfred Sze Lok Cheng; Wei Kang; Ka-Fai To; Dariusz Plewczynski; Qingpeng Zhang; Xiaoting Chen; Danny Cheuk Wing Chan; Ho Ko; Sunny Hei Wong; Jun Yu; Matthew Tak Vai Chan; Lin Zhang; William Ka Kei Wu
Metabolism and Chemical Biology
Disrupting Circadian Rhythm via the PER1–HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer
Jiao Wang; Qiong Huang; Xingbin Hu; Shuyi Zhang; Yu Jiang; Guangyu Yao; Kongzhen Hu; Xin Xu; Bishan Liang; Qijing Wu; Zhenfeng Ma; Yawen Wang; Chunlin Wang; Zhenzhen Wu; Xiaoxiang Rong; Wangjun Liao; Min Shi
In trastuzumab-resistant HER2-positive gastric cancer, glycolysis fluctuates with a circadian oscillation regulated by the BMAL1–CLOCK–PER1–HK2 axis, which can be disrupted with a metformin-based chronotherapy to overcome trastuzumab resistance.
Molecular Cell Biology
Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer
Fen Ma; Seiji Arai; Keshan Wang; Carla Calagua; Amanda R. Yuan; Larysa Poluben; Zhongkai Gu; Joshua W. Russo; David J. Einstein; Huihui Ye; Meng Xiao He; Yu Liu; Eliezer Van Allen; Adam G. Sowalsky; Manoj K. Bhasin; Xin Yuan; Steven P. Balk
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma
Nicholas T. Younger; Mollie L. Wilson; Anabel Martinez Lyons; Edward J. Jarman; Alison M. Meynert; Graeme R. Grimes; Konstantinos Gournopanos; Scott H. Waddell; Peter A. Tennant; David H. Wilson; Rachel V. Guest; Stephen J. Wigmore; Juan Carlos Acosta; Timothy J. Kendall; Martin S. Taylor; Duncan Sproul; Pleasantine Mill; Luke Boulter
Tumor Biology and Immunology
Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer
Ruozheng Wei; Yuning Zhou; Chang Li; Piotr Rychahou; Shulin Zhang; William B. Titlow; Greg Bauman; Yuanyuan Wu; Jinpeng Liu; Chi Wang; Heidi L. Weiss; B. Mark Evers; Qingding Wang
Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities
Maryam Yousefi; Gábor Boross; Carly Weiss; Christopher W. Murray; Jess D. Hebert; Hongchen Cai; Emily L. Ashkin; Saswati Karmakar; Laura Andrejka; Leo Chen; Minwei Wang; Min K. Tsai; Wen-Yang Lin; Chuan Li; Pegah Yakhchalian; Caterina I. Colón; Su-Kit Chew; Pauline Chu; Charles Swanton; Christian A. Kunder; Dmitri A. Petrov; Monte M. Winslow
Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis
Yang Cheng; Fuxiang Bai; Xiaolei Ren; Renhui Sun; Xiaowei Guo; Wen Liu; Bo Wang; Yongheng Yang; Xiaolu Zhang; Yong Xu; Chunyang Li; Xiaoyun Yang; Lifen Gao; Chunhong Ma; Xueen Li; Xiaohong Liang
Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation
Divya Sekar; Christina Dillmann; Evelyn Sirait-Fischer; Annika F. Fink; Aleksandra Zivkovic; Natalie Baum; Elisabeth Strack; Stephan Klatt; Sven Zukunft; Stefan Wallner; Arnaud Descot; Catherine Olesch; Priscila da Silva; Andreas von Knethen; Tobias Schmid; Sabine Grösch; Rajkumar Savai; Nerea Ferreirós; Ingrid Fleming; Sourav Ghosh; Carla V. Rothlin; Holger Stark; Hind Medyouf; Bernhard Brüne; Andreas Weigert
Translational Science
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
Jieun Son; Jaebong Jang; Tyler S. Beyett; Yoonji Eum; Heidi M. Haikala; Alyssa Verano; Mika Lin; John M. Hatcher; Nicholas P. Kwiatkowski; Pinar Ö. Eser; Michael J. Poitras; Stephen Wang; Man Xu; Prafulla C. Gokhale; Michael D. Cameron; Michael J. Eck; Nathanael S. Gray; Pasi A. Jänne
Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification
Benedetta Pellegrino; Andrea Herencia-Ropero; Alba Llop-Guevara; Flaminia Pedretti; Alejandro Moles-Fernández; Cristina Viaplana; Guillermo Villacampa; Marta Guzmán; Olga Rodríguez; Judit Grueso; Jose Jiménez; Enrique J. Arenas; Andrea Degasperi; João M.L. Dias; Josep V. Forment; Mark J. O'Connor; Olivier Déas; Stefano Cairo; Yinghui Zhou; Antonino Musolino; Carlos Caldas; Serena Nik-Zainal; Robert B. Clarke; Paolo Nuciforo; Orland Díez; Xavier Serres-Créixams; Vicente Peg; Martín Espinosa-Bravo; Teresa Macarulla; Ana Oaknin; Joaquin Mateo; Joaquín Arribas; Rodrigo Dienstmann; Meritxell Bellet; Mafalda Oliveira; Cristina Saura; Sara Gutiérrez-Enríquez; Judith Balmaña; Violeta Serra
Convergence and Technologies
Editor's Notes
Editor's Note: miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Lei Zhang; Karen Pickard; Veronika Jenei; Marc D. Bullock; Amanda Bruce; Richard Mitter; Gavin Kelly; Christos Paraskeva; John Strefford; John Primrose; Gareth J. Thomas; Graham Packham; Alex H. Mirnezami
Editor's Note: ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy
Yosra Messai; Muhammad Zaeem Noman; Meriem Hasmim; Bassam Janji; Andrés Tittarelli; Marie Boutet; Véronique Baud; Elodie Viry; Katy Billot; Arash Nanbakhsh; Thouraya Ben Safta; Catherine Richon; Sophie Ferlicot; Emmanuel Donnadieu; Sophie Couve; Betty Gardie; Florence Orlanducci; Laurence Albiges; Jerome Thiery; Daniel Olive; Bernard Escudier; Salem Chouaib
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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