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1 April 2022
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Cover Image
Intravesical chemotherapy for bladder cancer is unreliable and is also limited by incomplete drug delivery and poor compliance. A new urinary drug–disposing approach was developed to improve treatment outcomes by covering the entire urinary system, prolonging exposure of the tumor to drugs, and employing intravenous administration. For details, see the article by Bellat and colleagues on page 1409. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445
Cancer Research
Table of Contents
Breaking Insights
Editorial
Review
Cancer Research Landmarks
Cancer Research Highlights
Resource Report
Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Sonam Bhatia; Melissa Kramer; Suzanne Russo; Payal Naik; Gayatri Arun; Kyle Brophy; Peter Andrews; Cheng Fan; Charles M. Perou; Jonathan Preall; Taehoon Ha; Dennis Plenker; David A. Tuveson; Arvind Rishi; John E. Wilkinson; W. Richard McCombie; Karen Kostroff; David L. Spector
Genome and Epigenome
Somatic Mutations Enriched in Cis-Regulatory Elements Affect Genes Involved in Embryonic Development and Immune System Response in Neuroblastoma
Vito Alessandro Lasorsa; Annalaura Montella; Sueva Cantalupo; Matilde Tirelli; Carmen de Torres; Sanja Aveic; Gian Paolo Tonini; Achille Iolascon; Mario Capasso
Combined Inhibition of G9a and EZH2 Suppresses Tumor Growth via Synergistic Induction of IL24-Mediated Apoptosis
Francesco Casciello; Gregory M. Kelly; Priya Ramarao-Milne; Nabilah Kamal; Teneale A. Stewart; Pamela Mukhopadhyay; Stephen H. Kazakoff; Mariska Miranda; Dorim Kim; Felicity M. Davis; Nicholas K. Hayward; Paula M. Vertino; Nicola Waddell; Frank Gannon; Jason S. Lee
Association of Genetic Ancestry and Molecular Signatures with Cancer Survival Disparities: A Pan-Cancer Analysis
Kara Keun Lee; Lavanya Rishishwar; Dongjo Ban; Shashwat Deepali Nagar; Leonardo Mariño-Ramírez; John F. McDonald; I. King Jordan
This large-cohort, multicancer study identifies four cancer types with cancer survival disparities and seven cancer-related genes that interact with genetic ancestry and contribute to disparities.
Metabolism and Chemical Biology
Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Mario R. Fernandez; Franz X. Schaub; Chunying Yang; Weimin Li; Seongseok Yun; Stephanie K. Schaub; Frank C. Dorsey; Min Liu; Meredith A. Steeves; Andrea Ballabio; Alexandar Tzankov; Zhihua Chen; John M. Koomen; Anders E. Berglund; John L. Cleveland
MYC suppresses TFEB and autophagy and controls amino acid homeostasis by upregulating amino acid transport and the proteasome, and reactivation of TFEB disables the metabolism of MYC-driven tumors.
A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma
Jennifer G. Gill; Samantha N. Leef; Vijayashree Ramesh; Misty S. Martin-Sandoval; Aparna D. Rao; Lindsey West; Sarah Muh; Wen Gu; Zhiyu Zhao; Gregory A. Hosler; Travis W. Vandergriff; Alison B. Durham; Thomas P. Mathews; Arin B. Aurora
Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Luigi Ippolito; Giuseppina Comito; Matteo Parri; Marta Iozzo; Assia Duatti; Francesca Virgilio; Nicla Lorito; Marina Bacci; Elisa Pardella; Giada Sandrini; Francesca Bianchini; Roberta Damiano; Lavinia Ferrone; Giancarlo la Marca; Sergio Serni; Pietro Spatafora; Carlo V. Catapano; Andrea Morandi; Elisa Giannoni; Paola Chiarugi
Molecular Cell Biology
Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity
Jaione Auzmendi-Iriarte; Maddalen Otaegi-Ugartemendia; Estefania Carrasco-Garcia; Mikel Azkargorta; Antonio Diaz; Ander Saenz-Antoñanzas; Joaquin Andrés Andermatten; Mikel Garcia-Puga; Idoia Garcia; Alejandro Elua-Pinin; Irune Ruiz; Nicolas Sampron; Felix Elortza; Ana Maria Cuervo; Ander Matheu
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy
Zhipeng Hong; Tao Liu; Lingfeng Wan; Pengyan Fa; Pankaj Kumar; Yanan Cao; Chandra Bhushan Prasad; Zhaojun Qiu; Joseph Liu; Hongbing Wang; Zaibo Li; Qi-En Wang; Peixuan Guo; Deliang Guo; Ayse S. Yilmaz; Lanchun Lu; Ioanna Papandreou; Naduparambil K. Jacob; Chunhong Yan; Xiaoli Zhang; Qing-Bai She; Zhefu Ma; Junran Zhang
Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis
Zheqi Li; Yang Wu; Megan E. Yates; Nilgun Tasdemir; Amir Bahreini; Jian Chen; Kevin M. Levine; Nolan M. Priedigkeit; Azadeh Nasrazadani; Simak Ali; Laki Buluwela; Spencer Arnesen; Jason Gertz; Jennifer K. Richer; Benjamin Troness; Dorraya El-Ashry; Qiang Zhang; Lorenzo Gerratana; Youbin Zhang; Massimo Cristofanilli; Maritza A. Montanez; Prithu Sundd; Callen T. Wallace; Simon C. Watkins; Caterina Fumagalli; Elena Guerini-Rocco; Li Zhu; George C. Tseng; Nikhil Wagle; Jason S. Carroll; Paul Jank; Carsten Denkert; Maria M. Karsten; Jens-Uwe Blohmer; Ben H. Park; Peter C. Lucas; Jennifer M. Atkinson; Adrian V. Lee; Steffi Oesterreich
Tumor Biology and Immunology
Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis
Eiman Elwakeel; Mirko Brüggemann; Jessica Wagih; Olga Lityagina; Mohammed A.F. Elewa; Yingying Han; Timo Frömel; Rüdiger Popp; Adele M. Nicolas; Yannick Schreiber; Elise Gradhand; Dominique Thomas; Rolf Nüsing; Julia Steinmetz-Späh; Rajkumar Savai; Emmanouil Fokas; Ingrid Fleming; Florian R. Greten; Kathi Zarnack; Bernhard Brüne; Andreas Weigert
Translational Science
PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer
Carmen Ghilardi; Catarina Moreira-Barbosa; Laura Brunelli; Paola Ostano; Nicolò Panini; Monica Lupi; Alessia Anastasia; Fabio Fiordaliso; Monica Salio; Laura Formenti; Massimo Russo; Edoardo Arrigoni; Ferdinando Chiaradonna; Giovanna Chiorino; Giulio Draetta; Joseph R. Marszalek; Christopher P. Vellano; Roberta Pastorelli; MariaRosa Bani; Alessandra Decio; Raffaella Giavazzi
Corrections
Correction: Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase
Xiaozhen He; Bin Yan; Shuang Liu; Jiantao Jia; Weiwei Lai; Xing Xin; Can-e Tang; Dixian Luo; Tan Tan; Yiqun Jiang; Ying Shi; Yating Liu; Desheng Xiao; Ling Chen; Shao Liu; Chao Mao; Gang Yin; Yan Cheng; Jia Fan; Ya Cao; Kathrin Muegge; Yongguang Tao
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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