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Volume 82, Issue 5
1 March 2022
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    The long noncoding RNA HOXC-AS3 is activated upon glucose deprivation to trigger a switch in glucose metabolism. HOXC-AS3 selectively antagonizes SIRT6-mediated H3K9ac deacetylation of glycolysis-related genes and promotes metabolic reprogramming of breast cancers. Administration of anti-HOXC-AS3-motif-RNAs effectively blocks the function of HOXC-AS3, ultimately suppressing breast cancer progression. For details, see article by Zhu and colleagues on page 805.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Insights

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Obituary

In Memoriam: Beatrice Mintz, PhD (1921–2022)
Anna Marie Skalka; Jonathan Chernoff
View articletitled, In Memoriam: Beatrice Mintz, PhD (1921–2022)
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Reviews

Tipping Cancer Cells Over the Edge: The Context-Dependent Cost of High Ploidy
Noemi Andor; Philipp M. Altrock; Navami Jain; Ana P. Gomes
View articletitled, Tipping Cancer Cells Over the Edge: The Context-Dependent Cost of High Ploidy
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Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape
Ayalew Tefferi; Naseema Gangat; Animesh Pardanani; John D. Crispino
View articletitled, Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape
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Cancer Research Highlights

Rules of Engagement: The Lymphocyte Receptor Ecosystem in Renal Cell Carcinoma
Chirag Krishna; A. Ari Hakimi
View articletitled, Rules of Engagement: The Lymphocyte Receptor Ecosystem in Renal Cell Carcinoma
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Beyond T Cells: IgA Incites Immune Recognition in Endometrial Cancer
Juan C. Osorio; Dmitriy Zamarin
View articletitled, Beyond T Cells: IgA Incites Immune Recognition in Endometrial Cancer
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Controversy and Consensus

Glioblastoma: The Current State of Biology and Therapeutic Strategies
Zev A. Binder; Donald M. O'Rourke
View articletitled, Glioblastoma: The Current State of Biology and Therapeutic Strategies
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Priority Reports

Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy
Songfa Zhang; Chuan Yan; David G. Millar; Qiqi Yang; James M. Heather; Adam Langenbucher; Laura T. Morton; Sean Sepulveda; Eric Alpert; Lauren R. Whelton; Dominique T. Zarrella; Mei Guo; Eleanor Minogue; Michael S. Lawrence; Bo R. Rueda; David R. Spriggs; Weiguo Lu; David M. Langenau; Mark Cobbold
View articletitled, Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy
Supplementary data
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Resource Report

Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers
Zhao Zhang; Mei Luo; Qiang Li; Yuan Liu; Charles Lussier; Jian Zhang; Youqiong Ye; An-Yuan Guo; Leng Han
View articletitled, Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers
Supplementary data
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Genome and Epigenome

Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability
Xiaoyu Liu; Zhi Li; Zhongmin Wang; Fei Liu; Linling Zhang; Jingjing Ke; Xu Xu; Yuefang Zhang; Yiting Yuan; Tao Wei; Qungang Shan; Yingjie Chen; Wei Huang; Jie Gao; Nan Wu; Fuliang Chen; Lunquan Sun; Zilong Qiu; Yuezhen Deng; Xiaojing Wang
View articletitled, Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability
Supplementary data
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Metabolism and Chemical Biology

Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer
Wenjie Zhu; Xu Chen; Xiangyu Guo; Haiting Liu; Ranran Ma; Yawen Wang; Yahang Liang; Ying Sun; Mengqi Wang; Ruinan Zhao; Peng Gao
View articletitled, Low Glucose–Induced Overexpression of <em>HOXC-AS3</em> Promotes Metabolic Reprogramming of Breast Cancer
Supplementary data
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Molecular Cell Biology

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Katrina M. Lappin; Eliana M. Barros; Satpal S. Jhujh; Gareth W. Irwin; Hayley McMillan; Fabio G. Liberante; Cheryl Latimer; Melissa J. La Bonte; Ken I. Mills; D. Paul Harkin; Grant S. Stewart; Kienan I. Savage
View articletitled, Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Supplementary data
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EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling
Xingkang Jiang; Shanqi Guo; Shuo Wang; Yangyi Zhang; Haojie Chen; Yong Wang; Ranlu Liu; Yuanjie Niu; Yong Xu
View articletitled, EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling
Supplementary data
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AMPK–mTOR–Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells
Bo You; Tian Xia; Miao Gu; Zhenxin Zhang; Qicheng Zhang; Jianhong Shen; Yue Fan; Hui Yao; Si Pan; Yingna Lu; Tianyi Cheng; Zhiyuan Yang; Xin He; Hao Zhang; Muqi Shi; Dong Liu; Yiwen You
View articletitled, AMPK–mTOR–Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells
Supplementary data
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Tumor Biology and Immunology

IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Gunjan Mandal; Subir Biswas; Carmen M. Anadon; Xiaoqing Yu; Chandler D. Gatenbee; Sandhya Prabhakaran; Kyle K. Payne; Ricardo A. Chaurio; Alexandra Martin; Patrick Innamarato; Carlos Moran; John J. Powers; Carly M. Harro; Jessica A. Mine; Kimberly B. Sprenger; Kristen E. Rigolizzo; Xuefeng Wang; Tyler J. Curiel; Paulo C. Rodriguez; Alexander R. Anderson; Ozlen Saglam; Jose R. Conejo-Garcia
View articletitled, IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary data
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The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies
Jinru Xie; Ming Wen; Jiao Zhang; Zheng Wang; Meng Wang; Yanfang Qiu; Wenchao Zhao; Fang Zhu; Mianfeng Yao; Zhuoxian Rong; Wenfeng Hu; Qian Pei; Xiaoxiang Sun; Jinchen Li; Zhiyong Mao; Lun-Quan Sun; Rong Tan
View articletitled, The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies
Supplementary data
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Single-Cell Analysis Unveils the Role of the Tumor Immune Microenvironment and Notch Signaling in Dormant Minimal Residual Disease
Mahnaz Janghorban; Yuchen Yang; Na Zhao; Clark Hamor; Tuan M. Nguyen; Xiang H.-F. Zhang; Jeffrey M. Rosen
View articletitled, Single-Cell Analysis Unveils the Role of the Tumor Immune Microenvironment and Notch Signaling in Dormant Minimal Residual Disease
Supplementary data
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Translational Science

ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth
Wai Kit Ma; Dillon M. Voss; Juergen Scharner; Ana S.H. Costa; Kuan-Ting Lin; Hyun Yong Jeon; John E. Wilkinson; Michaela Jackson; Frank Rigo; C. Frank Bennett; Adrian R. Krainer
View articletitled, ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth
Supplementary data
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p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
David P. Molkentine; Jessica M. Molkentine; Kathleen A. Bridges; David R. Valdecanas; Annika Dhawan; Reshub Bahri; Andrew J. Hefner; Manish Kumar; Liangpeng Yang; Mohamed Abdelhakiem; Phillip M. Pifer; Vlad Sandulache; Aakash Sheth; Beth M. Beadle; Howard D. Thames; Kathryn A. Mason; Curtis R. Pickering; Raymond E. Meyn; Heath D. Skinner
View articletitled, p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Supplementary data
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Convergence and Technologies

Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
Meghan C. Ferrall-Fairbanks; Nicholas H. Chakiryan; Boris I. Chobrutskiy; Youngchul Kim; Jamie K. Teer; Anders Berglund; James J. Mulé; Michelle Fournier; Erin M. Siegel; Jasreman Dhillon; Seyed Shayan A. Falasiri; Juan F. Arturo; Esther N. Katende; George Blanck; Brandon J. Manley; Philipp M. Altrock
View articletitled, Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
Supplementary data
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Editor's Note

Editor's Note: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Danielle M. Gilkes; Pallavi Chaturvedi; Saumendra Bajpai; Carmen C. Wong; Hong Wei; Stephen Pitcairn; Maimon E. Hubbi; Denis Wirtz; Gregg L. Semenza
View articletitled, Editor's Note: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
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Corrections

Correction: Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation
Laura E. Jackson; Sucheta Kulkarni; Huabo Wang; Jie Lu; James M. Dolezal; Sivakama S. Bharathi; Sarangarajan Ranganathan; Mulchand S. Patel; Rahul Deshpande; Frances Alencastro; Stacy G. Wendell; Eric S. Goetzman; Andrew W. Duncan; Edward V. Prochownik
View articletitled, Correction: Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation
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Correction: Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages
Pan Su; Qiang Wang; Enguang Bi; Xingzhe Ma; Lintao Liu; Maojie Yang; Jianfei Qian; Qing Yi
View articletitled, Correction: Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages
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