Skip Nav Destination
Issues
1 January 2022
-
Cover Image
Cover Image
EGFR tyrosine kinase inhibitors are the standard-of-care treatment for EGFR-mutant non-small cell lung cancer, but tumors frequently develop acquired drug resistance. Targeting the EGFR dimerization partner HER3 has the potential to improve efficacy of EGFR inhibitors. The HER3 antibody–drug conjugate patritumab deruxtecan (red) is shown binding the extracellular domain of HER3 (blue). EGFR (white) inhibition with an EGFR tyrosine kinase inhibitor (depicted as a black intracellular domain) leads to an increase in cell surface HER3. For details, see the article by Haikala and colleagues on page 130.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Landmarks
Cancer Research Highlights
Controversy and Consensus
Genome and Epigenome
Molecular Cell Biology
The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma
Xinxin Ren; Zhuoxian Rong; Xiaoyu Liu; Jie Gao; Xu Xu; Yuyuan Zi; Yun Mu; Yidi Guan; Zhen Cao; Yuefang Zhang; Zimei Zeng; Qi Fan; Xitao Wang; Qian Pei; Xiang Wang; Haiguang Xin; Zhi Li; Yingjie Nie; Zilong Qiu; Nan Li; Lunquan Sun; Yuezhen Deng
Oncogenic circRNA C190 Promotes Non–Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway
Afeez Adekunle Ishola; Chian-Shiu Chien; Yi-Ping Yang; Yueh Chien; Aliaksandr A. Yarmishyn; Ping-Hsing Tsai; Jerry Chieh-Yu Chen; Po-Kuei Hsu; Yung-Hung Luo; Yuh-Min Chen; Kung-Hou Liang; Yuan-Tzu Lan; Teh-Ia Huo; Hsin-I. Ma; Ming-Teh Chen; Mong-Lien Wang; Shih-Hwa Chiou
Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth
Danielle R. Cook; Melissa Kang; Timothy D. Martin; Joseph A. Galanko; Gabriela H. Loeza; Dimitri G. Trembath; Verline Justilien; Karen A. Pickering; David F. Vincent; Armin Jarosch; Philipp Jurmeister; Andrew M. Waters; Priya S. Hibshman; Andrew D. Campbell; Catriona A. Ford; Temitope O. Keku; Jen Jen Yeh; Michael S. Lee; Adrienne D. Cox; Alan P. Fields; Robert S. Sandler; Owen J. Sansom; Christine Sers; Antje Schaefer; Channing J. Der
Tumor Biology and Immunology
Translational Science
EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd
Heidi M. Haikala; Timothy Lopez; Jens Köhler; Pinar O. Eser; Man Xu; Qing Zeng; Tyler J. Teceno; Kenneth Ngo; Yutong Zhao; Elena V. Ivanova; Arrien A. Bertram; Brittaney A. Leeper; Emily S. Chambers; Anika E. Adeni; Luke J. Taus; Mari Kuraguchi; Paul T. Kirschmeier; Channing Yu; Yoshinobu Shiose; Yasuki Kamai; Yang Qiu; Cloud P. Paweletz; Prafulla C. Gokhale; Pasi A. Jänne
Neoadjuvant Chemotherapy Induces Genomic and Transcriptomic Changes in Ovarian Cancer
Melissa Javellana; Mark A. Eckert; Janna Heide; Katarzyna Zawieracz; Melanie Weigert; Sarah Ashley; Elizabeth Stock; David Chapel; Lei Huang; S. Diane Yamada; Ahmed Ashour Ahmed; Ricardo R. Lastra; Mengjie Chen; Ernst Lengyel
Acknowledgment to Reviewers
Advertisement