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Volume 81, Issue 8
15 April 2021
Cancer Research Cover Image for Volume 81, Issue 8
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  • Cover Image

    Cover Image

    Issue cover image
    Immunofluorescence staining of the postpartum mouse mammary gland shows membrane-bound β-catenin (white) and nuclei (blue). YAP increases β-catenin activity to facilitate the luminal to basal transdifferentiation of mammary cells and promotes basal-like cancer formation. Targeting the YAP/TEAD4/β-catenin complex offers a potential therapeutic strategy for treating basal-like breast cancers. For details, see article by Quinn and colleagues on page 2116.
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Insights

Highlights from Recent Cancer Literature
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Review

Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer Therapy
Fatemeh Amjadi-Moheb; Alireza Paniri; Haleh Akhavan-Niaki
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Cancer Research Highlights

Towards Taming the Bugs to Improve the Drugs for Breast Cancer
Dipali Sharma
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Moving Toward the Ideal Autologous Adoptive T-cell Therapy for Cancer
Brian H. Ladle
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Genome and Epigenome

miR-31 Displays Subtype Specificity in Lung Cancer
Mackenzie L. Davenport; John B. Echols; Austin D. Silva; Joshua C. Anderson; Philip Owens; Clayton Yates; Qing Wei; Shuko Harada; Douglas R. Hurst; Mick D. Edmonds
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Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk
Thorhildur Olafsdottir; Simon N. Stacey; Gardar Sveinbjornsson; Gudmar Thorleifsson; Kristjan Norland; Bardur Sigurgeirsson; Kristin Thorisdottir; Arni Kjalar Kristjansson; Laufey Tryggvadottir; Kavita Y. Sarin; Rafn Benediktsson; Jon G. Jonasson; Asgeir Sigurdsson; Aslaug Jonasdottir; Snaedis Kristmundsdottir; Hakon Jonsson; Arnaldur Gylfason; Asmundur Oddsson; Run Fridriksdottir; Sigurjon A. Gudjonsson; Florian Zink; Sigrun H. Lund; Solvi Rognvaldsson; Pall Melsted; Valgerdur Steinthorsdottir; Julius Gudmundsson; Evgenia Mikaelsdottir; Pall I. Olason; Lilja Stefansdottir; Hannes P. Eggertsson; Bjarni V. Halldorsson; Unnur Thorsteinsdottir; Tomas T. Agustsson; Karl Olafsson; Jon H. Olafsson; Patrick Sulem; Thorunn Rafnar; Daniel F. Gudbjartsson; Kari Stefansson
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Author Choice
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes
Minjung Lee; Jianfang Li; Jia Li; Shaohai Fang; Joanna Zhang; Anh Tran Tram Vo; Wei Han; Hongxiang Zeng; Sevinj Isgandarova; Margarita Martinez-Moczygemba; Yubin Zhou; Deqiang Sun; Yun Huang
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Chr20q Amplification Defines a Distinct Molecular Subtype of Microsatellite Stable Colorectal Cancer
Baoyi Zhang; Kevin Yao; Emily Zhou; Lanjing Zhang; Chao Cheng
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Metabolism and Chemical Biology

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis
Lindsay A. Broadfield; João André Gonçalves Duarte; Roberta Schmieder; Dorien Broekaert; Koen Veys; Mélanie Planque; Kim Vriens; Yasuaki Karasawa; Francesco Napolitano; Suguru Fujita; Masashi Fujii; Miki Eto; Bryan Holvoet; Roman Vangoitsenhoven; Juan Fernandez-Garcia; Joke Van Elsen; Jonas Dehairs; Jia Zeng; James Dooley; Rebeca Alba Rubio; Jos van Pelt; Thomas G.P. Grünewald; Adrian Liston; Chantal Mathieu; Christophe M. Deroose; Johannes V. Swinnen; Diether Lambrechts; Diego di Bernardo; Shinya Kuroda; Katrien De Bock; Sarah-Maria Fendt
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Molecular Cell Biology

Author Choice
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules
Kamini Singh; Jianan Lin; Nicolas Lecomte; Prathibha Mohan; Askan Gokce; Viraj R. Sanghvi; Man Jiang; Olivera Grbovic-Huezo; Antonija Burčul; Stefan G. Stark; Paul B. Romesser; Qing Chang; Jerry P. Melchor; Rachel K. Beyer; Mark Duggan; Yoshiyuki Fukase; Guangli Yang; Ouathek Ouerfelli; Agnes Viale; Elisa de Stanchina; Andrew W. Stamford; Peter T. Meinke; Gunnar Rätsch; Steven D. Leach; Zhengqing Ouyang; Hans-Guido Wendel
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HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness
Lei Bi; Yidan Ren; Maoxiao Feng; Peng Meng; Qin Wang; Weiping Chen; Qinlian Jiao; Yuli Wang; Lutao Du; Fuqiong Zhou; Yucui Jiang; Feiyan Chen; Chuanxin Wang; Bo Tang; Yunshan Wang
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PLEKHA4 Promotes Wnt/β-Catenin Signaling–Mediated G1–S Transition and Proliferation in Melanoma
Adnan Shami Shah; Xiaofu Cao; Andrew C. White; Jeremy M. Baskin
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The miR–181a–SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer
Anil Belur Nagaraj; Matthew Knarr; Sreeja Sekhar; R. Shae Connor; Peronne Joseph; Olga Kovalenko; Alexis Fleming; Arshia Surti; Elmar Nurmemmedov; Luca Beltrame; Sergio Marchini; Michael Kahn; Analisa DiFeo
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Data-Driven Computational Modeling Identifies Determinants of Glioblastoma Response to SHP2 Inhibition
Evan K. Day; Qing Zhong; Benjamin Purow; Matthew J. Lazzara
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Targeting Pan-ETS Factors Inhibits Melanoma Progression
Lee Huang; Yougang Zhai; Jennifer La; Jason W. Lui; Stephen P.G. Moore; Elizabeth C. Little; Sixia Xiao; Adil J. Haresi; Candice Brem; Jag Bhawan; Deborah Lang
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Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex
Andrii Kovalenko; Andres Sanin; Kosmas Kosmas; Long Zhang; Ji Wang; Elie W. Akl; Krinio Giannikou; Clemens K. Probst; Thomas R. Hougard; Ryan W. Rue; Vera P. Krymskaya; John M. Asara; Hilaire C. Lam; David J. Kwiatkowski; Elizabeth P. Henske; Harilaos Filippakis
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Tumor Biology and Immunology

The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2
Tracy J. Berg; Carolina Marques; Vasiliki Pantazopoulou; Elinn Johansson; Kristoffer von Stedingk; David Lindgren; Pauline Jeannot; Elin J. Pietras; Tobias Bergström; Fredrik J. Swartling; Valeria Governa; Johan Bengzon; Mattias Belting; Håkan Axelson; Massimo Squatrito; Alexander Pietras
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Author Choice
YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer
Hazel M. Quinn; Regina Vogel; Oliver Popp; Philipp Mertins; Linxiang Lan; Clemens Messerschmidt; Alexandro Landshammer; Kamil Lisek; Sophie Château-Joubert; Elisabetta Marangoni; Elle Koren; Yaron Fuchs; Walter Birchmeier
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Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction
Guillaume Rieunier; Xiaoning Wu; Letitia E. Harris; Jack V. Mills; Ashwin Nandakumar; Laura Colling; Elena Seraia; Stephanie B. Hatch; Daniel V. Ebner; Lisa K. Folkes; Ulrike Weyer-Czernilofsky; Thomas Bogenrieder; Anderson J. Ryan; Valentine M. Macaulay
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Tumor-Derived Pericytes Driven by EGFR Mutations Govern the Vascular and Immune Microenvironment of Gliomas
Berta Segura-Collar; María Garranzo-Asensio; Beatriz Herranz; Esther Hernández-SanMiguel; Teresa Cejalvo; Bárbara S. Casas; Ander Matheu; Ángel Pérez-Núñez; Juan Manuel Sepúlveda-Sánchez; Aurelio Hernández-Laín; Verónica Palma; Ricardo Gargini; Pilar Sánchez-Gómez
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Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer
Kenji Unno; Zachary R. Chalmers; Sahithi Pamarthy; Rajita Vatapalli; Yara Rodriguez; Barbara Lysy; Hanlin Mok; Vinay Sagar; Huiying Han; Young A. Yoo; Sheng-Yu Ku; Himisha Beltran; Yue Zhao; Sarki A. Abdulkadir
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Ubiquitin-Specific Protease 6 Functions as a Tumor Suppressor in Ewing Sarcoma through Immune Activation
Ian C. Henrich; Kanika Jain; Robert Young; Laura Quick; Jarrett M. Lindsay; Daniel H. Park; Andre M. Oliveira; Gerd A. Blobel; Margaret M. Chou
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Translational Science

T Cells Expanded from PD-1+ Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes
Tiepeng Li; Lingdi Zhao; Yonghao Yang; Yao Wang; Yong Zhang; Jindong Guo; Guangyu Chen; Peng Qin; Benling Xu; Baozhen Ma; Fang Zhang; Yiman Shang; Qingjun Li; Kai Zhang; Dongfeng Yuan; Chaojie Feng; Yan Ma; Zhiyong Liu; Zhichao Tian; Hongle Li; Shengdian Wang; Quanli Gao
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Featured Image
Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer
Martina Di Modica; Giorgio Gargari; Viola Regondi; Arianna Bonizzi; Stefania Arioli; Beatrice Belmonte; Loris De Cecco; Elena Fasano; Francesca Bianchi; Alessia Bertolotti; Claudio Tripodo; Laura Villani; Fabio Corsi; Simone Guglielmetti; Andrea Balsari; Tiziana Triulzi; Elda Tagliabue
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Pronociceptive Roles of Schwann Cell–Derived Galectin-3 in Taxane-Induced Peripheral Neuropathy
Madoka Koyanagi; Satoshi Imai; Mayuna Matsumoto; Yoko Iguma; Nobuko Kawaguchi-Sakita; Takeshi Kotake; Yuki Iwamitsu; Mpumelelo Ntogwa; Ren Hiraiwa; Kazuki Nagayasu; Mamiko Saigo; Takashi Ogihara; Atsushi Yonezawa; Tomohiro Omura; Shunsaku Nakagawa; Takayuki Nakagawa; Kazuo Matsubara
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Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors
Natalia Filippova; Xiuhua Yang; Subramaniam Ananthan; Jennifer Calano; Vibha Pathak; Larry Bratton; Rakesh H. Vekariya; Sixue Zhang; Edward Ofori; Emily N. Hayward; David Namkoong; David K. Crossman; Michael R. Crowley; Peter H. King; James Mobley; Louis B. Nabors
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Convergence and Technologies

Cytoplasmic Localization of Prostate-Specific Membrane Antigen Inhibitors May Confer Advantages for Targeted Cancer Therapies
Jessica Matthias; Johann Engelhardt; Martin Schäfer; Ulrike Bauder-Wüst; Philipp T. Meyer; Uwe Haberkorn; Matthias Eder; Klaus Kopka; Stefan W. Hell; Ann-Christin Eder
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Population and Prevention Science

Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts
Barbara J. Fuhrman; Steven C. Moore; Celia Byrne; Issam Makhoul; Cari M. Kitahara; Amy Berrington de González; Martha S. Linet; Elisabete Weiderpass; Hans-Olov Adami; Neal D. Freedman; Linda M. Liao; Charles E. Matthews; Rachael Z. Stolzenberg-Solomon; Mia M. Gaudet; Alpa V. Patel; I-Min Lee; Julie E. Buring; Alicja Wolk; Susanna C. Larsson; Anna E. Prizment; Kim Robien; Michael Spriggs; David P. Check; Neil Murphy; Marc J. Gunter; Harold L. Van Dusen, Jr; Regina G. Ziegler; Robert N. Hoover
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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