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15 March 2021
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Association of breast cancer subtypes with distinct metabolic phenotypes identified isocitrate dehydrogenase 2 (IDH2) as a key player in triple-negative breast cancer (TNBC) and HER2 subtypes. Wild-type IDH2 promoted cell proliferation, anchorage-independent growth, glycolysis, mitochondrial respiration, and antioxidant defense, thus revealing its protumorigenic role in TNBC cells. Serine biosynthesis pathway proteins were found to be metabolic synthetic dosage lethal partners of IDH2. Pharmacological inhibition of PHGDH sensitized cells with high IDH2 and inhibited tumor growth in vivo, emphasizing PHGDH inhibition as a therapeutic approach for triple-negative breast tumors with high IDH2. For details, see article by Barnabas and colleagues on page 1443.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Obituary
Ralph A. Reisfeld, PhD: In Memoriam (1926–2020)
James P. Allison; Edward Barker; Jürgen C. Becker; Thomas F. Bumol; David Cheresh; Bill Church; Soldano Ferrone; Darrell R. Galloway; Martin Giedlin; Stephen Gillies; Rupert Handgretinger; John R. Harper; Kohzoh Imai; Barry Kahan; Ruth Ladenstein; Debbie Liao; Holger N. Lode; Hans Loibner; Yun-Ping Luo; Barbara M. Mueller; AhKau Ng; Andreas Niethammer; Michele Pellegrino; Ursula Pertl; Vito Quaranta; Carlo Russo; Helen Sabzevari; Martin Schrappe; Gregor Schulz; Paul Sondel; Andreas Stahl; Argyrios Theophilopoulos; Nissi Varki; Leslie Walker; Barry Wilson; Wolfgang Wrasidlo; Ursula Wargalla-Plate; Rong Xiang; Alice Yu; He Zhou
Review
Cancer Research Highlights
Metabolism and Chemical Biology
Molecular Cell Biology
Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma
Sanhita Mitra; Somsundar Veppil Muralidharan; Mirco Di Marco; Prasanna Kumar Juvvuna; Subazini Thankaswamy Kosalai; Silke Reischl; Daniel Jachimowicz; Santhilal Subhash; Ivan Raimondi; Leo Kurian; Maite Huarte; Per Kogner; Matthias Fischer; John Inge Johnsen; Tanmoy Mondal; Chandrasekhar Kanduri
Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth
Shinji Iizuka; Manuela Quintavalle; Jose C. Navarro; Kyle P. Gribbin; Robert J. Ardecky; Matthew M. Abelman; Chen-Ting Ma; Eduard Sergienko; Fu-Yue Zeng; Ian Pass; George V. Thomas; Shannon K. McWeeney; Christian A. Hassig; Anthony B. Pinkerton; Sara A. Courtneidge
A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis
Priyanka Kulkarni; Pritha Dasgupta; Yutaka Hashimoto; Marisa Shiina; Varahram Shahryari; Z. Laura Tabatabai; Soichiro Yamamura; Yuichiro Tanaka; Sharanjot Saini; Rajvir Dahiya; Shahana Majid
Tumor Biology and Immunology
The BRCA1 Pseudogene Negatively Regulates Antitumor Responses through Inhibition of Innate Immune Defense Mechanisms
Yoo Jane Han; Jing Zhang; Jung-Hyun Lee; Jennifer M. Mason; Olga Karginova; Toshio F. Yoshimatsu; Qinyu Hao; Ian Hurley; Laia Paré Brunet; Aleix Prat; Kannanganattu V. Prasanth; Michaela U. Gack; Olufunmilayo I. Olopade
Translational Science
Bladder Tumor Subtype Commitment Occurs in Carcinoma In Situ Driven by Key Signaling Pathways Including ECM Remodeling
Adrian Wullweber; Reiner Strick; Fabienne Lange; Danijel Sikic; Helge Taubert; Sven Wach; Bernd Wullich; Simone Bertz; Veronika Weyerer; Robert Stoehr; Johannes Breyer; Maximilian Burger; Arndt Hartmann; Pamela L. Strissel; Markus Eckstein
Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Oleta A. Sandiford; Robert J. Donnelly; Markos H. El-Far; Lisa M. Burgmeyer; Garima Sinha; Sri Harika Pamarthi; Lauren S. Sherman; Alejandra I. Ferrer; Dariana E. DeVore; Shyam A. Patel; Yahaira Naaldijk; Sara Alonso; Pradeep Barak; Margarette Bryan; Nicholas M. Ponzio; Ramaswamy Narayanan; Jean-Pierre Etchegaray; Rakesh Kumar; Pranela Rameshwar
EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers
Mélanie K. Prodhomme; Roxane M. Pommier; Camille Franchet; Frédérique Fauvet; Valérie Bergoglio; Pierre Brousset; Anne-Pierre Morel; Anne-Cécile Brunac; Mojgan Devouassoux-Shisheboran; Virginie Petrilli; Caroline Moyret-Lalle; Jean-Sébastien Hoffmann; Alain Puisieux; Agnès Tissier
Population and Prevention Science
Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model
Rayjean J. Hung; Matthew T. Warkentin; Yonathan Brhane; Nilanjan Chatterjee; David C. Christiani; Maria Teresa Landi; Neil E. Caporaso; Geoffrey Liu; Mattias Johansson; Demetrius Albanes; Loic Le Marchand; Adonina Tardon; Gad Rennert; Stig E. Bojesen; Chu Chen; John K. Field; Lambertus A. Kiemeney; Philip Lazarus; Shanbeth Zienolddiny; Stephen Lam; Angeline S. Andrew; Susanne M. Arnold; Melinda C. Aldrich; Heike Bickeböller; Angela Risch; Matthew B. Schabath; James D. McKay; Paul Brennan; Christopher I. Amos
Retraction
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