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Volume 81, Issue 5

1 March 2021

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Cover Image

Cover Image

Cancer is a heterogeneous disease with extensive genetic complexity. The circles in the middle represent a normal cell with germline variations. In cancer, germline variants can affect the tumor mutational burden, both of which contribute to the emergence of different types of cancer cells. For details, see article by Sun and colleagues on page 1230.
Table of Contents
Editorial Board

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Insights
Reviews
Controversy and Consensus
Cancer Research Highlights
Genome and Epigenome
Metabolism and Chemical Biology
Molecular Cell Biology
Tumor Biology and Immunology
Translational Science

Cancer Research

Breaking Insights

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Reviews

Preclinical Applications of Multi-Platform Imaging in Animal Models of Cancer

Natalie J. Serkova; Kristine Glunde; Chad R. Haney; Mohammed Farhoud; Alexandra De Lille; Elizabeth F. Redente; Dmitri Simberg; David C. Westerly; Lynn Griffin; Ralph P. Mason

Abstract

View articletitled, Preclinical Applications of Multi-Platform Imaging in Animal Models of Cancer

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Author Choice

Macrophage-Based Approaches for Cancer Immunotherapy

Nicholas R. Anderson; Nicholas G. Minutolo; Saar Gill; Michael Klichinsky

Abstract

View articletitled, Macrophage-Based Approaches for Cancer Immunotherapy

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Controversy and Consensus

Is COVID-19–Induced Platelet Activation a Cause of Concern for Patients with Cancer?

Lenard M. Lichtenberger; K. Vinod Vijayan

Abstract

View articletitled, Is COVID-19–Induced Platelet Activation a Cause of Concern for Patients with Cancer?

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Cancer Research Highlights

Being Small and Intronic: miRNAs That Count!

George A. Calin

Abstract

View articletitled, Being Small and Intronic: miRNAs That Count!

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Which Holds the Key to BRCAness: Inability to Repair the Break, Protect the Fork, or Prevent the Gap?

Christine E. Canman

Abstract

View articletitled, Which Holds the Key to BRCAness: Inability to Repair the Break, Protect the Fork, or Prevent the Gap?

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Genome and Epigenome

Author Choice

A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Sai Ma; Bo Zhou; Qian Yang; Yunzhi Pan; Wei Yang; Stephen J. Freedland; Ling-Wen Ding; Michael R. Freeman; Joshua J. Breunig; Neil A. Bhowmick; Jian Pan; H. Phillip Koeffler; De-Chen Lin

Abstracts

View articletitled, A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Supplementary data

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Author Choice

Tumor Mutational Burden Is Polygenic and Genetically Associated with Complex Traits and Diseases

Xiwei Sun; Angli Xue; Ting Qi; Dan Chen; Dandan Shi; Yang Wu; Zhili Zheng; Jian Zeng; Jian Yang

Abstracts

View articletitled, Tumor Mutational Burden Is Polygenic and Genetically Associated with Complex Traits and Diseases

Supplementary data

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Metabolism and Chemical Biology

Oncogenic N-Ras Mitigates Oxidative Stress–Induced Apoptosis of Hematopoietic Stem Cells

Gina M. Ney; Kevin B. Yang; Victor Ng; Lu Liu; Meiling Zhao; Wun Kuk; Lila Alaka; Leilani Sampang; Adam Ross; Morgan A. Jones; Xi Jin; Laura M. McKay; Hadie Evarts; Qing Li

Abstracts

View articletitled, Oncogenic N-Ras Mitigates Oxidative Stress–Induced Apoptosis of Hematopoietic Stem Cells

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Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Katelyn D. Miller; Katherine Pniewski; Caroline E. Perry; Sara B. Papp; Joshua D. Shaffer; Jesse N. Velasco-Silva; Jessica C. Casciano; Tomas M. Aramburu; Yellamelli V.V. Srikanth; Joel Cassel; Emmanuel Skordalakes; Andrew V. Kossenkov; Joseph M. Salvino; Zachary T. Schug

Abstracts

View articletitled, Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Supplementary data

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Molecular Cell Biology

Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1

Zhaoji Liu; Linchong Sun; Yongping Cai; Shengqi Shen; Tong Zhang; Nana Wang; Gongwei Wu; Wenhao Ma; Shi-Ting Li; Caixia Suo; Yijie Hao; Wei-Dong Jia; Gregg L. Semenza; Ping Gao; Huafeng Zhang

Abstracts

View articletitled, Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1

Supplementary data

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MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters

Oren Yakovian; Julia Sajman; Rand Arafeh; Yair Neve-Oz; Michal Alon; Yardena Samuels; Eilon Sherman

Abstracts

View articletitled, MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters

Supplementary data

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PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis

Lilia Gheghiani; Lei Wang; Youwei Zhang; Xavier T.R. Moore; Jinglei Zhang; Steven C. Smith; Yijun Tian; Liang Wang; Kristi Turner; Colleen K. Jackson-Cook; Nitai D. Mukhopadhyay; Zheng Fu

Abstracts

View articletitled, PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis

Supplementary data

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Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development

Zhi Hao Kwok; Bin Zhang; Xiao Hong Chew; Jia Jia Chan; Velda Teh; Henry Yang; Dennis Kappei; Yvonne Tay

Abstracts

View articletitled, Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent <em>FTX</em> Locus to Promote Colon Cancer Development

Supplementary data

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USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma

Tibor Bedekovics; Sajjad Hussain; Ying Zhang; Asma Ali; Young J. Jeon; Paul J. Galardy

Abstracts

View articletitled, <em>USP24</em> Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma

Supplementary data

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Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways

Meiou Dai; Julien Boudreault; Ni Wang; Sophie Poulet; Girija Daliah; Gang Yan; Alaa Moamer; Sergio A. Burgos; Siham Sabri; Suhad Ali; Jean-Jacques Lebrun

Abstracts

View articletitled, Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways

Supplementary data

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Functional Determinants of Cell Cycle Plasticity and Sensitivity to CDK4/6 Inhibition

Vishnu Kumarasamy; Paris Vail; Ram Nambiar; Agnieszka K. Witkiewicz; Erik S. Knudsen

Abstracts

View articletitled, Functional Determinants of Cell Cycle Plasticity and Sensitivity to CDK4/6 Inhibition

Supplementary data

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A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma

Qingqing Zhou; Wei Tian; Zhiyuan Jiang; Tingting Huang; Chao Ge; Tengfei Liu; Fangyu Zhao; Taoyang Chen; Ying Cui; Hong Li; Ming Yao; Jinjun Li; Hua Tian

Abstracts

View articletitled, A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma

Supplementary data

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Tumor Biology and Immunology

Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity

Gonzalo R. Sequeira; Ana Sahores; Tomás Dalotto-Moreno; Ramiro M. Perrotta; Gabriela Pataccini; Silvia I. Vanzulli; María L. Polo; Derek C. Radisky; Carol A. Sartorius; Virginia Novaro; Caroline A. Lamb; Gabriel A. Rabinovich; Mariana Salatino; Claudia Lanari

Abstracts

View articletitled, Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity

Supplementary data

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Author Choice

Replication Gaps Underlie BRCA Deficiency and Therapy Response

Nicholas J. Panzarino; John J. Krais; Ke Cong; Min Peng; Michelle Mosqueda; Sumeet U. Nayak; Samuel M. Bond; Jennifer A. Calvo; Mihir B. Doshi; Matt Bere; Jianhong Ou; Bin Deng; Lihua J. Zhu; Neil Johnson; Sharon B. Cantor

Abstracts

View articletitled, Replication Gaps Underlie BRCA Deficiency and Therapy Response

Supplementary data

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Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC

Jessica M. Konen; B. Leticia Rodriguez; Aparna Padhye; Joshua K. Ochieng; Laura Gibson; Lixia Diao; Natalie W. Fowlkes; Jared J. Fradette; David H. Peng; Robert J. Cardnell; Jeffrey J. Kovacs; Jing Wang; Lauren A. Byers; Don L. Gibbons

Abstracts

View articletitled, Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC

Supplementary data

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Translational Science

Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma

Lizhen Liu; Sailan Liu; Peng Deng; Yujing Liang; Rong Xiao; Lin-Quan Tang; Jinghong Chen; Qiu-Yan Chen; Peiyong Guan; Shu-Mei Yan; Xiangliang Huang; Jing Han Hong; Jianfeng Chen; Yichen Sun; Bin Tean Teh; Qiang Yu; Hai-Qiang Mai; Jing Tan

Abstracts

View articletitled, Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma

Supplementary data

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Journal Archive

Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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Cover Image

Cancer Research

Table of Contents

Breaking Insights

Reviews

Controversy and Consensus

Cancer Research Highlights

Genome and Epigenome

Metabolism and Chemical Biology

Molecular Cell Biology

Tumor Biology and Immunology

Translational Science

Journal Archive

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