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1 March 2021
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Cover Image
Cover Image
Cancer is a heterogeneous disease with extensive genetic complexity. The circles in the middle represent a normal cell with germline variations. In cancer, germline variants can affect the tumor mutational burden, both of which contribute to the emergence of different types of cancer cells. For details, see article by Sun and colleagues on page 1230.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Reviews
Controversy and Consensus
Cancer Research Highlights
Genome and Epigenome
Author Choice
A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma
Sai Ma; Bo Zhou; Qian Yang; Yunzhi Pan; Wei Yang; Stephen J. Freedland; Ling-Wen Ding; Michael R. Freeman; Joshua J. Breunig; Neil A. Bhowmick; Jian Pan; H. Phillip Koeffler; De-Chen Lin
Metabolism and Chemical Biology
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth
Katelyn D. Miller; Katherine Pniewski; Caroline E. Perry; Sara B. Papp; Joshua D. Shaffer; Jesse N. Velasco-Silva; Jessica C. Casciano; Tomas M. Aramburu; Yellamelli V.V. Srikanth; Joel Cassel; Emmanuel Skordalakes; Andrew V. Kossenkov; Joseph M. Salvino; Zachary T. Schug
Molecular Cell Biology
Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1
Zhaoji Liu; Linchong Sun; Yongping Cai; Shengqi Shen; Tong Zhang; Nana Wang; Gongwei Wu; Wenhao Ma; Shi-Ting Li; Caixia Suo; Yijie Hao; Wei-Dong Jia; Gregg L. Semenza; Ping Gao; Huafeng Zhang
Tumor Biology and Immunology
Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity
Gonzalo R. Sequeira; Ana Sahores; Tomás Dalotto-Moreno; Ramiro M. Perrotta; Gabriela Pataccini; Silvia I. Vanzulli; María L. Polo; Derek C. Radisky; Carol A. Sartorius; Virginia Novaro; Caroline A. Lamb; Gabriel A. Rabinovich; Mariana Salatino; Claudia Lanari
Dual Inhibition of MEK and AXL Targets Tumor Cell Heterogeneity and Prevents Resistant Outgrowth Mediated by the Epithelial-to-Mesenchymal Transition in NSCLC
Jessica M. Konen; B. Leticia Rodriguez; Aparna Padhye; Joshua K. Ochieng; Laura Gibson; Lixia Diao; Natalie W. Fowlkes; Jared J. Fradette; David H. Peng; Robert J. Cardnell; Jeffrey J. Kovacs; Jing Wang; Lauren A. Byers; Don L. Gibbons
Translational Science
Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma
Lizhen Liu; Sailan Liu; Peng Deng; Yujing Liang; Rong Xiao; Lin-Quan Tang; Jinghong Chen; Qiu-Yan Chen; Peiyong Guan; Shu-Mei Yan; Xiangliang Huang; Jing Han Hong; Jianfeng Chen; Yichen Sun; Bin Tean Teh; Qiang Yu; Hai-Qiang Mai; Jing Tan
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