Skip Nav Destination
Issues
15 February 2021
-
Cover Image
Cover Image
Adaptive cancer therapy aims to delay cancer progression by exploiting competition between drug-sensitive and -resistant cells in the tumor. Drug dosing is adapted in a patient-specific fashion to maintain drug-sensitive cells that competitively suppress resistance (blue). This is in contrast to standard-of-care cancer treatment regimens that maximize cell kill and thereby cause the rapid competitive release of drug-resistant cells (orange). But, when will adaptive therapy work? Shown is a collage of so-called “phase plane” visualizations of a mathematical model with which the authors address this question. Each triangle represents a different parameterization. It was found that resource availability, resistance fraction, resistance cost, and cellular turnover integrate to modulate intratumoral competition. For details, see article by Strobl and colleagues on page 1135.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Reviews
Cancer Research Highlights
Controversy and Consensus
Genome and Epigenome
Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML
Gabriele Greve; Julia Schüler; Björn A. Grüning; Bettina Berberich; Julia Stomper; Dennis Zimmer; Lea Gutenkunst; Ulrike Bönisch; Ruth Meier; Nadja Blagitko-Dorfs; Olga Grishina; Dietmar Pfeifer; Dieter Weichenhan; Christoph Plass; Michael Lübbert
Author Choice
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
Barrie Peck; Philip Bland; Ioanna Mavrommati; Gareth Muirhead; Hannah Cottom; Patty T. Wai; Sarah L. Maguire; Holly E. Barker; Eamonn Morrison; Divya Kriplani; Lu Yu; Amy Gibson; Giulia Falgari; Keith Brennan; Gillian Farnie; Richard Buus; Rebecca Marlow; Daniela Novo; Eleanor Knight; Naomi Guppy; Daniela Kolarevic; Snezana Susnjar; Natasa Medic Milijic; Kalnisha Naidoo; Patrycja Gazinska; Ioannis Roxanis; Sunil Pancholi; Lesley-Ann Martin; Erle M. Holgersen; Maggie C.U. Cheang; Farzana Noor; Sophie Postel-Vinay; Gerard Quinn; Simon McDade; Lukas Krasny; Paul Huang; Frances Daley; Fredrik Wallberg; Jyoti S. Choudhary; Syed Haider; Andrew N. Tutt; Rachael Natrajan
Metabolism and Chemical Biology
Molecular Cell Biology
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression
Yinmin Gu; Shaoxi Niu; Yang Wang; Liqiang Duan; Yongbo Pan; Zhou Tong; Xu Zhang; Zhenyu Yang; Bo Peng; Xiaodong Wang; Xiaoqi Han; Yuxin Li; Tianyou Cheng; Yajuan Liu; Lina Shang; Tongfeng Liu; Xiwang Yang; Minxuan Sun; Siyuan Jiang; Chang Zhang; Ning Zhang; Qinong Ye; Shan Gao
Tumor Biology and Immunology
Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function
Linnéa La Fleur; Johan Botling; Fei He; Catarina Pelicano; Chikai Zhou; Chenfei He; Giorgia Palano; Artur Mezheyeuski; Patrick Micke; Jeffrey V. Ravetch; Mikael C. I. Karlsson; Dhifaf Sarhan
Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment
José M. Carbó; Theresa E. León; Joan Font-Díaz; Juan Vladimir De la Rosa; Antonio Castrillo; Felix R. Picard; Daniel Staudenraus; Magdalena Huber; Lídia Cedó; Joan Carles Escolà-Gil; Lucía Campos; Latifa Bakiri; Erwin F. Wagner; Carme Caelles; Thomas Stratmann; Jo A. Van Ginderachter; Annabel F. Valledor
ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly
Shayi Wu; Miao Chen; Jiao Huang; Feifei Zhang; Zhaojie Lv; Yongxu Jia; Yu-Zhu Cui; Liang-Zhan Sun; Ying Wang; Ying Tang; Krista R. Verhoeft; Yan Li; Yanru Qin; Xiang Lin; Xin-Yuan Guan; Ka-On Lam
Newly Identified Members of FGFR1 Splice Variants Engage in Cross-talk with AXL/AKT Axis in Salivary Adenoid Cystic Carcinoma
Joseph O. Humtsoe; Hyun-Su Kim; Brandon Leonard; Shizhang Ling; Bhumsuk Keam; Luigi Marchionni; Bahman Afsari; Michael Considine; Alexander V. Favorov; Elana J. Fertig; Hyunseok Kang; Patrick K. Ha
Cancer Cell Fitness Is Dynamic
Luana S. Lenz; Juliano L. Faccioni; Paula A. Bracco; Jephesson A.F. Santos; Luiza C. Pereira; Julieti H. Buss; Mauricio T. Tamborindeguy; Daphne Torgo; Thayana Monteiro; Giovana B. Mantovani; Carolina N. Santo; Julia C. Marcolin; Eloisa Dalsin; Alvaro Vigo; Sidia M. Callegari-Jacques; Andrew O. Silva; Giovana R. Onzi; Karine R. Begnini; Guido Lenz
Translational Science
Author Choice
E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling
Kazuhiko Yamada; Yusaku Hori; Satoshi Inoue; Yuji Yamamoto; Kentaro Iso; Hiroshi Kamiyama; Atsumi Yamaguchi; Takayuki Kimura; Mai Uesugi; Junichi Ito; Masahiro Matsuki; Kazutaka Nakamoto; Hitoshi Harada; Naoki Yoneda; Atsushi Takemura; Ikuo Kushida; Naomi Wakayama; Kenji Kubara; Yu Kato; Taro Semba; Akira Yokoi; Masayuki Matsukura; Takenao Odagami; Masao Iwata; Akihiko Tsuruoka; Toshimitsu Uenaka; Junji Matsui; Tomohiro Matsushima; Kenichi Nomoto; Hiroyuki Kouji; Takashi Owa; Yasuhiro Funahashi; Yoichi Ozawa
Author Choice
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer
Alec Paschalis; Jonathan Welti; Antje J. Neeb; Wei Yuan; Ines Figueiredo; Rita Pereira; Ana Ferreira; Ruth Riisnaes; Daniel Nava Rodrigues; Juan M. Jiménez-Vacas; Soojin Kim; Takuma Uo; Patrizio Di Micco; Anthony Tumber; Md. Saiful Islam; Marc A. Moesser; Martine Abboud; Akane Kawamura; Bora Gurel; Rossitza Christova; Veronica S. Gil; Lorenzo Buroni; Mateus Crespo; Susana Miranda; Maryou B. Lambros; Suzanne Carreira; Nina Tunariu; Andrea Alimonti; Bissan Al-Lazikani; Christopher J. Schofield; Stephen R. Plymate; Adam Sharp; Johann S. de Bono; , SU2C/PCF International Prostate Cancer Dream Team
Convergence and Technologies
Population and Prevention Science
Resource Reports
Advertisement