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Volume 81, Issue 22

15 November 2021

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Cover Image

Cover Image

Various types of cancer overexpress oncogenic miRNAs, making them a potential therapeutic target. Next-generation chemically modified triplex peptide nucleic acid–based miR-155 inhibitors possess superior therapeutic efficacy compared with conventional full-length anti-miR-155. The cover depicts intratumoral treatment with the next-generation anti-miRNA-155 inhibitor. For details, see article by Dhuri and colleagues on page 5613.
Table of Contents
Editorial Board

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Insights
Obituary
Reviews
Cancer Research Landmarks
Cancer Research Highlights
Genome and Epigenome
Molecular Cell Biology
Tumor Biology and Immunology
Translational Science
Convergence and Technologies
Correction

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Breaking Insights

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Obituary

Joseph R. Bertino: In Memoriam (1930–2021)

William N. Hait

Extract

View articletitled, Joseph R. Bertino: In Memoriam (1930–2021)

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Reviews

Epigenetic Alterations and Mechanisms That Drive Resistance to Targeted Cancer Therapies

Narendra Wajapeyee; Romi Gupta

Abstract

View articletitled, Epigenetic Alterations and Mechanisms That Drive Resistance to Targeted Cancer Therapies

Supplementary data

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The Role of mRNA Translational Control in Tumor Immune Escape and Immunotherapy Resistance

Michaël Cerezo; Caroline Robert; Lunxu Liu; Shensi Shen

Abstract

View articletitled, The Role of mRNA Translational Control in Tumor Immune Escape and Immunotherapy Resistance

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Cancer Research Landmarks

PARP Inhibitors – Trapped in a Toxic Love Affair

Dragomir B. Krastev; Andrew J. Wicks; Christopher J. Lord

Abstract

View articletitled, PARP Inhibitors – Trapped in a Toxic Love Affair

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Cancer Research Highlights

mTOR-Dependent ARID1A Degradation: A New Twist in the Genetic–Epigenetic Interplay Driving Hepatocellular Carcinoma

David R. Pease; Martin E. Fernandez-Zapico

Abstract

View articletitled, mTOR-Dependent ARID1A Degradation: A New Twist in the Genetic–Epigenetic Interplay Driving Hepatocellular Carcinoma

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Collagen Linearization within Tumors

Craig E. Barcus; Gregory D. Longmore

Abstract

View articletitled, Collagen Linearization within Tumors

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Genome and Epigenome

Therapeutic Potential of Chemically Modified, Synthetic, Triplex Peptide Nucleic Acid–Based Oncomir Inhibitors for Cancer Therapy

Karishma Dhuri; Ravinder Reddy Gaddam; Ajit Vikram; Frank J. Slack; Raman Bahal

Abstracts

View articletitled, Therapeutic Potential of Chemically Modified, Synthetic, Triplex Peptide Nucleic Acid–Based Oncomir Inhibitors for Cancer Therapy

Supplementary data

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Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma

Ana Stosic; Fabio Fuligni; Nathaniel D. Anderson; Scott Davidson; Richard de Borja; Meryl Acker; Vito Forte; Paolo Campisi; Evan J. Propst; Nikolaus E. Wolter; Rose Chami; Ozgur Mete; David Malkin; Adam Shlien; Jonathan D. Wasserman

Abstracts

View articletitled, Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma

Supplementary data

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Molecular Cell Biology

CstF64-Induced Shortening of the BID 3′UTR Promotes Esophageal Squamous Cell Carcinoma Progression by Disrupting ceRNA Cross-talk with ZFP36L2

Ai Lin; Ping Ji; Xiangjie Niu; Xuan Zhao; Yamei Chen; Weiling Liu; Yachen Liu; Wenyi Fan; Yanxia Sun; Chuanwang Miao; Shaosen Zhang; Wen Tan; Dongxin Lin; Eric J. Wagner; Chen Wu

Abstracts

View articletitled, CstF64-Induced Shortening of the <em>BID</em> 3′UTR Promotes Esophageal Squamous Cell Carcinoma Progression by Disrupting ceRNA Cross-talk with <em>ZFP36L2</em>

Supplementary data

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mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma

Shanshan Zhang; Yu-Feng Zhou; Jian Cao; Stephen K. Burley; Hui-Yun Wang; X.F. Steven Zheng

Abstracts

View articletitled, mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma

Supplementary data

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Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis

Jagadeesh Janjanam; Glendin Pano; Ruishan Wang; Benjamin A. Minden-Birkenmaier; Hannah Breeze-Jones; Eleanor Baker; Cecile Garcin; Georgia Clayton; Abbas Shirinifard; Ana Maria Zaske; David Finkelstein; Myriam Labelle

Abstracts

View articletitled, Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis

Supplementary data

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LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway

Fengyu Xu; Mengqi Huang; Qingyong Chen; Yi Niu; Yuhang Hu; Ping Hu; Ding Chen; Chi He; Kang Huang; Zhu Zeng; Jiang Tang; Fan Wang; Yong Zhao; Chunyou Wang; Gang Zhao

Abstracts

View articletitled, LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway

Supplementary data

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Tumor Biology and Immunology

FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Jia-Jian Loh; Tsz-Wai Li; Lei Zhou; Tin-Lok Wong; Xue Liu; Victor W.S. Ma; Chung-Mau Lo; Kwan Man; Terence K. Lee; Wen Ning; Man Tong; Stephanie Ma

Abstracts

View articletitled, FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Supplementary data

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TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer

Laura S.M. Lecker; Chiara Berlato; Eleni Maniati; Robin Delaine-Smith; Oliver M.T. Pearce; Owen Heath; Samuel J. Nichols; Caterina Trevisan; Marian Novak; Jacqueline McDermott; James D. Brenton; Pedro R. Cutillas; Vinothini Rajeeve; Ana Hennino; Ronny Drapkin; Daniela Loessner; Frances R. Balkwill

Analysis of ECM changes during neoplastic transformation reveals a role for TGFBI secreted by macrophages in immunosuppression in early ovarian cancer.

Abstract

View articletitled, TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer

Supplementary data

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Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness

Lin Yang; Jingya Sun; Meiqian Li; Yiming Long; Dianzheng Zhang; Hongqian Guo; Ruimin Huang; Jun Yan

Abstracts

View articletitled, Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness

Supplementary data

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Translational Science

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Kumar Sanjiv; José Manuel Calderón-Montaño; Therese M. Pham; Tom Erkers; Viktoriia Tsuber; Ingrid Almlöf; Andreas Höglund; Yaser Heshmati; Brinton Seashore-Ludlow; Akhilesh Nagesh Danda; Helge Gad; Elisee Wiita; Camilla Göktürk; Azita Rasti; Stefanie Friedrich; Anders Centio; Montserrat Estruch; Thea Kristin Våtsveen; Nona Struyf; Torkild Visnes; Martin Scobie; Tobias Koolmeister; Martin Henriksson; Olov Wallner; Teresa Sandvall; Sören Lehmann; Kim Theilgaard-Mönch; Mathew J. Garnett; Päivi Östling; Julian Walfridsson; Thomas Helleday; Ulrika Warpman Berglund

The MTH1 inhibitor TH1579 is a potential novel AML treatment, targeting both blasts and the pivotal leukemic stem cells while sparing normal bone marrow cells.

Abstract

View articletitled, MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Supplementary data

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Convergence and Technologies

Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy

Santosh Kumar Paidi; Joel Rodriguez Troncoso; Piyush Raj; Paola Monterroso Diaz; Jesse D. Ivers; David E. Lee; Nathan L. Avaritt; Allen J. Gies; Charles M. Quick; Stephanie D. Byrum; Alan J. Tackett; Narasimhan Rajaram; Ishan Barman

Abstracts

View articletitled, Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy

Supplementary data

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Characterization of Peptides Targeting Metastatic Tumor Cells as Probes for Cancer Detection and Vehicles for Therapy Delivery

Shraddha Subramanian; Alexes C. Daquinag; Solmaz AghaAmiri; Sukhen C. Ghosh; Ali Azhdarinia; Mikhail G. Kolonin

Abstracts

View articletitled, Characterization of Peptides Targeting Metastatic Tumor Cells as Probes for Cancer Detection and Vehicles for Therapy Delivery

Supplementary data

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Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets

Shirin Elizabeth Khorsandi; Arran D. Dokal; Vinothini Rajeeve; David J. Britton; Megan S. Illingworth; Nigel Heaton; Pedro R. Cutillas

Phosphoproteomic and computational analyses identify patient-specific drug targets in cholangiocarcinoma, supporting the potential of a machine learning method to predict personalized therapies.

Abstract

View articletitled, Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets

Supplementary data

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