Association of triple-negative breast cancers with genomic characteristics identified decaprenyl diphosphate synthase subunit 1 (PDSS1) as a key player during the process of metastasis. The wild type of PDSS1 promotes cancer cell migration, invasion in vitro, and distant metastasis in vivo. The cover image depicts the metastatic process of human triple-negative breast cancer cell due to PDSS1 amplification. For details, see article by Yu and colleagues on page 5491.