High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of ovarian cancer cases, and it is most frequently diagnosed at advanced stages. The cover image captures a peritoneal micrometastasis formed in a new somatic HGSOC mouse model generated using a combination of in vivo electroporation and CRISPR-Cas9–mediated genome editing (red, RFP marking cancer cells; cyan, nucleus; white, F-actin). For details, see the article by Teng and colleagues on page 5147.