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Volume 81, Issue 19
1 October 2021
Cancer Research Cover Image for Volume 81, Issue 19
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  • Cover Image

    Cover Image

    Issue cover image
    The CD200-CD200R signaling axis plays an etiological role in the survival and spread of numerous cancers. CD200 stimulates metastasis of cutaneous squamous cell carcinoma (cSCC) via inducing expression of cysteine protease cathepsin K (Ctsk) in CD200R+ tumor-infiltrating myeloid cells. Inhibition of Ctsk blocks cSCC cell migration through collagen and blocks cSCC metastasis. The cover image depicts pan-cytokeratin+ (green) human cutaneous squamous cell carcinoma invading through type I collagen+ (red) stroma. For details, see the article by Khan and colleagues on page 5021.
  • PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Insights

Highlights from Recent Cancer Literature
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Review

Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies
Lin Yang; Andria R. Morielli; Emily Heer; Amy A. Kirkham; Winson Y. Cheung; Nawaid Usmani; Christine M. Friedenreich; Kerry S. Courneya
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Cancer Research Landmarks

Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect
Aaron M. Hosios; Brendan D. Manning
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Cancer Research Highlights

A Novel Long Noncoding RNA Finetunes the DNA Damage Response in Hepatocellular Carcinoma
Marina Barcena-Varela; Amaia Lujambio
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Priority Report

Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity
Kirsi Ketola; Heidi Kaljunen; Sinja Taavitsainen; Roosa Kaarijärvi; Emmi Järvelä; Bernardo Rodríguez-Martín; Kerstin Haase; Dan J. Woodcock; Jose Tubio; David C. Wedge; Matti Nykter; G. Steven Bova

Differential analysis of eradicated and resistant subclones following cancer treatment identifies that L1 activity associated with resistance is induced by current therapies and blocked by the antiretroviral drug azidothymidine.

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Genome and Epigenome

Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma
Juan P. Unfried; Mikel Marín-Baquero; Ángel Rivera-Calzada; Nerea Razquin; Eva M. Martín-Cuevas; Sara de Bragança; Clara Aicart-Ramos; Christopher McCoy; Laura Prats-Mari; Raquel Arribas-Bosacoma; Linda Lee; Stefano Caruso; Jessica Zucman-Rossi; Bruno Sangro; Gareth Williams; Fernando Moreno-Herrero; Oscar Llorca; Susan P. Lees-Miller; Puri Fortes
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The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Hidenari Hirata; Atsushi Niida; Nobuyuki Kakiuchi; Ryutaro Uchi; Keishi Sugimachi; Takaaki Masuda; Tomoko Saito; Shun-Ichiro Kageyama; Yushi Motomura; Shuhei Ito; Tadamasa Yoshitake; Daisuke Tsurumaru; Yusuke Nishimuta; Akira Yokoyama; Takanori Hasegawa; Kenichi Chiba; Yuichi Shiraishi; Junyan Du; Fumihito Miura; Masaru Morita; Yasushi Toh; Masakazu Hirakawa; Yoshiyuki Shioyama; Takashi Ito; Tetsuo Akimoto; Satoru Miyano; Tatsuhiro Shibata; Masaki Mori; Yutaka Suzuki; Seishi Ogawa; Kousei Ishigami; Koshi Mimori
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Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP
Mark Chen; Joseph P. Foster, II; Ian C. Lock; Nathan H. Leisenring; Andrea R. Daniel; Warren Floyd; Eric Xu; Ian J. Davis; David G. Kirsch
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Metabolism and Chemical Biology

Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program
Ke Tang; Liyan Zhu; Jie Chen; Dianheng Wang; Liping Zeng; Chen Chen; Liang Tang; Li Zhou; Keke Wei; Yabo Zhou; Jiadi Lv; Yuying Liu; Huafeng Zhang; Jingwei Ma; Bo Huang
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MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer
Qiangsheng Hu; Yi Qin; Shunrong Ji; Xiuhui Shi; Weixing Dai; Guixiong Fan; Shuo Li; Wenyan Xu; Wensheng Liu; Mengqi Liu; Zheng Zhang; Zeng Ye; Zhijun Zhou; Jingxuan Yang; Qifeng Zhuo; Xianjun Yu; Min Li; Xiaowu Xu
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Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition
Lisa M. Butler; Chui Yan Mah; Jelle Machiels; Andrew D. Vincent; Swati Irani; Shadrack M. Mutuku; Xander Spotbeen; Muralidhararao Bagadi; David Waltregny; Max Moldovan; Jonas Dehairs; Frank Vanderhoydonc; Katarzyna Bloch; Rajdeep Das; Jurgen Stahl; James G. Kench; Thomas Gevaert; Rita Derua; Etienne Waelkens; Zeyad D. Nassar; Luke A. Selth; Paul J. Trim; Marten F. Snel; David J. Lynn; Wayne D. Tilley; Lisa G. Horvath; Margaret M. Centenera; Johannes V. Swinnen
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Molecular Cell Biology

Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells
Anna Sole; Sandrine Grossetête; Maxime Heintzé; Loelia Babin; Sakina Zaïdi; Patrick Revy; Benjamin Renouf; Anne De Cian; Carine Giovannangeli; Cécile Pierre-Eugène; Isabelle Janoueix-Lerosey; Lucile Couronné; Sophie Kaltenbach; Mark Tomishima; Maria Jasin; Thomas G.P. Grünewald; Olivier Delattre; Didier Surdez; Erika Brunet
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AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4
Jinquan Liu; Bo Yuan; Jin Cao; Hongjie Luo; Shuchen Gu; Mengdi Zhang; Ran Ding; Long Zhang; Fangfang Zhou; Mien-Chie Hung; Pinglong Xu; Xia Lin; Jianping Jin; Xin-Hua Feng
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Tumor Biology and Immunology

The CD200–CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K
Iasha Z. Khan; Christina A. Del Guzzo; Anqi Shao; Jiyoon Cho; Rong Du; Adrienne O. Cohen; David M. Owens
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Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL
Liat Goldberg; Vijay Negi; Yang Jo Chung; Masahiro Onozawa; Yuelin J. Zhu; Robert L. Walker; Rachel Pierce; Daxesh P. Patel; Kristopher W. Krausz; Frank J. Gonzalez; Margaret A. Goodell; Benjamin A.T. Rodriguez; Paul S. Meltzer; Peter D. Aplan
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Featured Image
Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1–Dependent Myeloid Cells
Lee-Ann Van de Velde; E. Kaitlynn Allen; Jeremy Chase Crawford; Taylor L. Wilson; Clifford S. Guy; Marion Russier; Leonie Zeitler; Armita Bahrami; David Finkelstein; Stephane Pelletier; Stacey Schultz-Cherry; Paul G. Thomas; Peter J. Murray
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Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL-Deficient Kidney Tissue
Hieu-Huy Nguyen-Tran; Thi-Ngoc Nguyen; Chen-Yun Chen; Tien Hsu
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Epstein–Barr Virus–Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1
Junshang Ge; Jie Wang; Fang Xiong; Xianjie Jiang; Kunjie Zhu; Yian Wang; Yongzhen Mo; Zhaojian Gong; Shanshan Zhang; Yi He; Xiayu Li; Lei Shi; Can Guo; Fuyan Wang; Ming Zhou; Bo Xiang; Yong Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng
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Translational Science

Featured Image
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors
Silvia Maifrede; Bac Viet Le; Margaret Nieborowska-Skorska; Konstantin Golovine; Katherine Sullivan-Reed; Wangisa M.B. Dunuwille; Joseph Nacson; Michael Hulse; Kelsey Keith; Jozef Madzo; Lisa Beatrice Caruso; Zachary Gazze; Zhaorui Lian; Antonella Padella; Kumaraswamy N. Chitrala; Boris A. Bartholdy; Ksenia Matlawska-Wasowska; Daniela Di Marcantonio; Giorgia Simonetti; Georg Greiner; Stephen M. Sykes; Peter Valent; Elisabeth M. Paietta; Martin S. Tallman; Hugo F. Fernandez; Mark R. Litzow; Mark D. Minden; Jian Huang; Giovanni Martinelli; George S. Vassiliou; Italo Tempera; Katarzyna Piwocka; Neil Johnson; Grant A. Challen; Tomasz Skorski
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Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
Hayley M. Sabol; Adam J. Ferrari; Manish Adhikari; Tânia Amorim; Kevin McAndrews; Judith Anderson; Michele Vigolo; Rajwinder Lehal; Meloney Cregor; Sharmin Khan; Pedro L. Cuevas; Jill A. Helms; Noriyoshi Kurihara; Venkat Srinivasan; Frank H. Ebetino; Robert K. Boeckman, Jr; G. David Roodman; Teresita Bellido; Jesus Delgado-Calle
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Convergence and Technologies

Predicting Molecular Phenotypes from Histopathology Images: A Transcriptome-Wide Expression–Morphology Analysis in Breast Cancer
Yinxi Wang; Kimmo Kartasalo; Philippe Weitz; Balázs Ács; Masi Valkonen; Christer Larsson; Pekka Ruusuvuori; Johan Hartman; Mattias Rantalainen

Transcriptome-wide expression morphology deep learning analysis enables prediction of mRNA expression and proliferation markers from routine histopathology whole slide images in breast cancer.

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Correction

Correction: YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63–GPX2 Axis and ROS Accumulation
Hsinyi Huang; Wenjing Zhang; Yafang Pan; Yijun Gao; Lei Deng; Fuming Li; Fei Li; Xueyan Ma; Shenda Hou; Jing Xu; Peixue Li; Xiaoxun Li; Guohong Hu; Cheng Li; Haiquan Chen; Lei Zhang; Hongbin Ji
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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