Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Volume 81, Issue 17

1 September 2021

All Issues

Cover Image

Cover Image

LGR4/5/6 proteins play critical roles in development and cancer. The biological functions of these proteins have been primarily attributed to their roles in potentiating Wnt signaling. The mosaic photo illustrates widespread lung metastases in mice xenografted with green fluorescence–labeled human breast cancer cells expressing LGR4 mutants that cannot potentiate Wnt signaling, revealing that LGR4 promotes metastasis even when disengaged from Wnt signaling. For details, see article by Yue and colleagues on page 4441.
Table of Contents
Editorial Board

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Insights
Reviews
Cancer Research Landmarks
Cancer Research Highlights
Controversy and Consensus
Genome and Epigenome
Metabolism and Chemical Biology
Molecular Cell Biology
Tumor Biology and Immunology
Translational Science
Convergence and Technologies
Population and Prevention Science

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Breaking Insights

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

Open the PDF for in another window

Reviews

60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy

Nicoletta Cieri; Katie Maurer; Catherine J. Wu

Abstract

View articletitled, 60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy

Open the PDF for in another window

Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon?

Laura A. Sena; Samuel R. Denmeade

Abstract

View articletitled, Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon?

Open the PDF for in another window

Cancer Research Landmarks

The Landmark Discovery That Paved the Way to a Mechanistic Understanding of P53 Gain of Function and Personalized Medicine

Marco Napoli; Avani A. Deshpande; Elsa R. Flores

Abstract

View articletitled, The Landmark Discovery That Paved the Way to a Mechanistic Understanding of P53 Gain of Function and Personalized Medicine

Open the PDF for in another window

Cancer Research Highlights

LGR4: Not Just for Wnt Anymore?

Payton D. Stevens; Bart O. Williams

Abstract

View articletitled, LGR4: Not Just for Wnt Anymore?

Open the PDF for in another window

Controversy and Consensus

Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?

Christopher S. Nabel; Matthew G. Vander Heiden

Abstract

View articletitled, Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?

Open the PDF for in another window

Genome and Epigenome

The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers

Zhengjia Chen; Chao Zhang; Jianhong Chen; Dongsheng Wang; Jieqi Tu; Carter Van Waes; Nabil F. Saba; Zhuo G. Chen; Zhong Chen

Abstracts

View articletitled, The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers

Supplementary data

Open the PDF for in another window

Metabolism and Chemical Biology

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Nicole M. Anderson; Xiaodan Qin; Jennifer M. Finan; Andrew Lam; Jacob Athoe; Rindert Missiaen; Nicolas Skuli; Annie Kennedy; Amandeep S. Saini; Ting Tao; Shizhen Zhu; Itzhak Nissim; A. Thomas Look; Guoliang Qing; M. Celeste Simon; Hui Feng

Abstracts

View articletitled, Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Supplementary data

Open the PDF for in another window

PPARα Agonist Fenofibrate Enhances Cancer Vaccine Efficacy

Arezki Chekaoui; Hildegund C.J. Ertl

Abstracts

View articletitled, PPARα Agonist Fenofibrate Enhances Cancer Vaccine Efficacy

Supplementary data

Open the PDF for in another window

Molecular Cell Biology

A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis

Fei Yue; Weiyu Jiang; Amy T. Ku; Adelaide I.J. Young; Weijie Zhang; Eric P. Souto; Yankun Gao; Zihan Yu; Yi Wang; Chad J. Creighton; Chandandeep Nagi; Tao Wang; Susan G. Hilsenbeck; Xin-Hua Feng; Shixia Huang; Cristian Coarfa; Xiang H.-F. Zhang; Qingyun Liu; Xia Lin; Yi Li

Abstracts

View articletitled, A Wnt-Independent LGR4–EGFR Signaling Axis in Cancer Metastasis

Supplementary data

Open the PDF for in another window

AP-2α–Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis

Jeffrey R. White; Dakota T. Thompson; Kelsey E. Koch; Boris S. Kiriazov; Anna C. Beck; Dana M. van der Heide; Benjamin G. Grimm; Mikhail V. Kulak; Ronald J. Weigel

Abstracts

View articletitled, AP-2α–Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis

Supplementary data

Open the PDF for in another window

MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression

Zhenlin Huang; Bo Tang; Yinhui Yang; Zhaogang Yang; Lei Shi; Yang Bai; Binyuan Yan; R. Jeffrey Karnes; Jun Zhang; Rafael Jimenez; Liguo Wang; Qiang Wei; Jinjian Yang; Wanhai Xu; Zhankui Jia; Haojie Huang

Abstracts

View articletitled, MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression

Supplementary data

Open the PDF for in another window

Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling

Cheng Kong; Xuebing Yan; Yefei Zhu; Huiyuan Zhu; Ying Luo; Peipei Liu; Sylvain Ferrandon; Matthew F. Kalady; Renyuan Gao; Jide He; Fang Yin; Xiao Qu; Jiayi Zheng; Yaohui Gao; Qing Wei; Yanlei Ma; Jun-Yan Liu; Huanlong Qin

Abstracts

View articletitled, Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling

Supplementary data

Open the PDF for in another window

Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Abigael Cheruiyot; Shan Li; Sridhar Nonavinkere Srivatsan; Tanzir Ahmed; Yuhao Chen; Delphine S. Lemacon; Ying Li; Zheng Yang; Brian A. Wadugu; Wayne A. Warner; Shondra M. Pruett-Miller; Esther A. Obeng; Daniel C. Link; Dalin He; Fei Xiao; Xiaowei Wang; Julie M. Bailis; Matthew J. Walter; Zhongsheng You

Abstracts

View articletitled, Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Supplementary data

Open the PDF for in another window

Tumor Biology and Immunology

Mevalonate Blockade in Cancer Cells Triggers CLEC9A⁺ Dendritic Cell-Mediated Antitumor Immunity

Feifei Xu; Zining Wang; Hongxia Zhang; Jiemin Chen; Xiaojuan Wang; Lei Cui; Chunyuan Xie; Mengyun Li; Fang Wang; Penghui Zhou; Jinyun Liu; Peng Huang; Xiaodong Xia; Xiaojun Xia

Abstracts

View articletitled, Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity

Supplementary data

Open the PDF for in another window

E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer

Celia López-Menéndez; Alberto Vázquez-Naharro; Vanesa Santos; Pierre Dubus; Patricia G. Santamaría; Ángel Martínez-Ramírez; Francisco Portillo; Gema Moreno-Bueno; Marisa M. Faraldo; Amparo Cano

Abstracts

View articletitled, E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer

Supplementary data

Open the PDF for in another window

α₁-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages

Kotaro Matsusaka; Yukio Fujiwara; Cheng Pan; Shigeyuki Esumi; Yoichi Saito; Jing Bi; Yuka Nakamura; Ayumi Mukunoki; Toru Takeo; Naomi Nakagata; Daiki Yoshii; Ryo Fukuda; Taisei Nagasaki; Ryusei Tanaka; Hisakazu Komori; Hitoshi Maeda; Hiroshi Watanabe; Koji Tamada; Yoshihiro Komohara; Toru Maruyama

Abstracts

View articletitled, α1-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages

Supplementary data

Open the PDF for in another window

Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract

Talia R. Henkle; Brandon Lam; Yu Jui Kung; John Lin; Ssu-Hsueh Tseng; Louise Ferrall; Deyin Xing; Chien-Fu Hung; T.-C. Wu

This study describes the development of a clinically relevant mouse model of cervicovaginal carcinoma that progresses from high-grade lesions and recapitulates key features of human HPV⁺ cervical cancer.

Abstract

View articletitled, Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract

Supplementary data

Open the PDF for in another window