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Volume 81, Issue 13

1 July 2021

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Cover Image

Cover Image

Solute carrier 7A11 (SLC7A11) is expressed by cancer cells and cancer-associated fibroblasts in a human pancreatic cancer. The confocal image shows alpha-smooth muscle actin (green), SLC7A11 (red), and DAPI (blue) immunofluorescence staining in a human pancreatic tumor section. For details, see article by Sharbeen and colleagues on page 3461.
Table of Contents
Editorial Board

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Insights
Review
Cancer Research Highlights
Resource Report
Metabolism and Chemical Biology
Molecular Cell Biology
Tumor Biology and Immunology
Translational Science
Population and Prevention Science

Cancer Research

Breaking Insights

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Review

The Emerging Roles of RNA m⁶A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance

Qing Lan; Pei Y. Liu; Jessica L. Bell; Jenny Y. Wang; Stefan Hüttelmaier; Xu Dong Zhang; Lirong Zhang; Tao Liu

Abstract

View articletitled, The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance

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Cancer Research Highlights

Contemporary Lung Cancer Screening and the Promise of Blood-Based Biomarkers

Mitchell S. von Itzstein; David E. Gerber; John D. Minna

Abstract

View articletitled, Contemporary Lung Cancer Screening and the Promise of Blood-Based Biomarkers

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Imaging Early Response to Checkpoint Inhibition

Quinlan Cullen; Kayvan R. Keshari

Abstract

View articletitled, Imaging Early Response to Checkpoint Inhibition

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Artificial Intelligence in Surveillance of Barrett's Esophagus

Anant Madabhushi; Paula Toro; Joseph E. Willis

Abstract

View articletitled, Artificial Intelligence in Surveillance of Barrett's Esophagus

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Resource Report

Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers

Margaret C. Steiner; Jez L. Marston; Luis P. Iñiguez; Matthew L. Bendall; Katherine B. Chiappinelli; Douglas F. Nixon; Keith A. Crandall

Abstracts

View articletitled, Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers

Supplementary data

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Metabolism and Chemical Biology

Author Choice

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

George Sharbeen; Joshua A. McCarroll; Anouschka Akerman; Chantal Kopecky; Janet Youkhana; John Kokkinos; Jeff Holst; Cyrille Boyer; Mert Erkan; David Goldstein; Paul Timpson; Thomas R. Cox; Brooke A. Pereira; Jessica L. Chitty; Sigrid K. Fey; Arafath K. Najumudeen; Andrew D. Campbell; Owen J. Sansom; Rosa Mistica C. Ignacio; Stephanie Naim; Jie Liu; Nelson Russia; Julia Lee; Angela Chou; Amber Johns; Anthony J. Gill; Estrella Gonzales-Aloy; Val Gebski; Yi Fang Guan; Marina Pajic; Nigel Turner; Minoti V. Apte; Thomas P. Davis; Jennifer P. Morton; Koroush S. Haghighi; Jorjina Kasparian; Benjamin J. McLean; Yordanos F. Setargew; Phoebe A. Phillips; Australian Pancreatic Cancer Genome Initiative

Abstracts

View articletitled, Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Supplementary data

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Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate

Judith Goncalves; Sophie Moog; Aurélie Morin; Géraldine Gentric; Sebastian Müller; Alexander P. Morrell; Katarina Kluckova; Theodora J. Stewart; Cynthia L. Andoniadou; Charlotte Lussey-Lepoutre; Paule Bénit; Alpesh Thakker; Lisa Vettore; Jennie Roberts; Raphaël Rodriguez; Fatima Mechta-Grigoriou; Anne-Paule Gimenez-Roqueplo; Eric Letouzé; Daniel A. Tennant; Judith Favier

Abstracts

View articletitled, Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate

Supplementary data

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Molecular Cell Biology

Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth

Ken-ichi Takayama; Teruki Honma; Takashi Suzuki; Yasumitsu Kondoh; Hiroyuki Osada; Yutaka Suzuki; Minoru Yoshida; Satoshi Inoue

Abstracts

View articletitled, Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth

Supplementary data

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Long Noncoding RNA CTD-2245E15.3 Promotes Anabolic Enzymes ACC1 and PC to Support Non–Small Cell Lung Cancer Growth

Chen Wang; Xiangfeng Meng; Yu Zhou; Jing Yu; Qing Li; Zhicong Liao; Yuanyuan Gu; Jiayi Han; Shuo Linghu; Zichen Jiao; Tao Wang; Chen-Yu Zhang; Xi Chen

Abstracts

View articletitled, Long Noncoding RNA CTD-2245E15.3 Promotes Anabolic Enzymes ACC1 and PC to Support Non–Small Cell Lung Cancer Growth

Supplementary data

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Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer

Yue Li; Meng Wang; Muwen Yang; Yunyun Xiao; Yunting Jian; Dongni Shi; Xiangfu Chen; Ying Ouyang; Lingzhi Kong; Xinjian Huang; Jiewen Bai; Yameng Hu; Chuyong Lin; Libing Song

Abstracts

View articletitled, Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer

Supplementary data

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Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance

Miso Park; Ji Won Kim; Kyu Min Kim; Seungmin Kang; Wankyu Kim; Jin-Ki Kim; Youngnam Cho; Hyungjae Lee; Moon Chang Baek; Ju-Hyun Bae; Seung Hyun Lee; Sung Baek Jeong; Sung Chul Lim; Dae Won Jun; Sung Yun Cho; Yeonji Kim; Yong June Choi; Keon Wook Kang

Abstracts

View articletitled, Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance

Supplementary data

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Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma

Hanyu Rao; Xiaoxue Li; Min Liu; Jing Liu; Wenxin Feng; Huayuan Tang; Jin Xu; Wei-Qiang Gao; Li Li

Abstracts

View articletitled, Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma

Supplementary data

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TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer

Benjamin Schoeps; Celina Eckfeld; Olga Prokopchuk; Jan Böttcher; Daniel Häußler; Katja Steiger; Ihsan Ekin Demir; Percy Knolle; Oliver Soehnlein; Dieter E. Jenne; Chris D. Hermann; Achim Krüger

Abstracts

View articletitled, TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer

Supplementary data

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EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma

Minling Gao; Yi Fu; Weiqiang Zhou; Gege Gui; Bachuchu Lal; Yunqing Li; Shuli Xia; Hongkai Ji; Charles G. Eberhart; John Laterra; Mingyao Ying

Abstracts

View articletitled, EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma

Supplementary data

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Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression

Lei Shi; Yuqian Yan; Yundong He; Binyuan Yan; Yunqian Pan; Jacob J. Orme; Jun Zhang; Wanhai Xu; Jun Pang; Haojie Huang

Abstracts

View articletitled, Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression

Supplementary data

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Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response

Hyeongjwa Choi; Juntae Kwon; Min Soon Cho; Yifan Sun; Xiaofeng Zheng; Jing Wang; Kerrie B. Bouker; John L. Casey; Michael B. Atkins; Jeffrey Toretsky; Cecil Han

Abstracts

View articletitled, Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response

Supplementary data

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14-3-3σ Functions as an Intestinal Tumor Suppressor

Markus Winter; Matjaž Rokavec; Heiko Hermeking

Abstracts

View articletitled, 14-3-3σ Functions as an Intestinal Tumor Suppressor

Supplementary data

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Tumor Biology and Immunology

An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma

Rui Ma; Ting Lu; Zhenlong Li; Kun-Yu Teng; Anthony G. Mansour; Melissa Yu; Lei Tian; Bo Xu; Shoubao Ma; Jianying Zhang; Tasha Barr; Yong Peng; Michael A. Caligiuri; Jianhua Yu

Abstracts

View articletitled, An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma

Supplementary data

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Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells

Lauren A. Hapach; Shawn P. Carey; Samantha C. Schwager; Paul V. Taufalele; Wenjun Wang; Jenna A. Mosier; Nerymar Ortiz-Otero; Tanner J. McArdle; Zachary E. Goldblatt; Marsha C. Lampi; Francois Bordeleau; Jocelyn R. Marshall; Isaac M. Richardson; Jiahe Li; Michael R. King; Cynthia A. Reinhart-King

Abstracts

View articletitled, Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells

Supplementary data

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SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

Rafael S. Martinez; Mark J. Salji; Linda Rushworth; Chara Ntala; Giovanny Rodriguez Blanco; Ann Hedley; William Clark; Paul Peixoto; Eric Hervouet; Elodie Renaude; Sonia H.Y. Kung; Laura C.A. Galbraith; Colin Nixon; Sergio Lilla; Gillian M. MacKay; Ladan Fazli; Luke Gaughan; David Sumpton; Martin E. Gleave; Sara Zanivan; Arnaud Blomme; Hing Y. Leung

Abstracts

View articletitled, SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

Supplementary data

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Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling

Angel P.Y. Ma; Cherlie L.S. Yeung; Sze Keong Tey; Xiaowen Mao; Samuel W.K. Wong; Tung Him Ng; Frankie C.F. Ko; Ernest M.L. Kwong; Alexander H.N. Tang; Irene Oi-Lin Ng; Shao Hang Cai; Jing Ping Yun; Judy W.P. Yam

Abstracts

View articletitled, Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling

Supplementary data

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Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

Yu Saida; Jeffrey R. Brender; Kazutoshi Yamamoto; James B. Mitchell; Murali C. Krishna; Shun Kishimoto

Abstracts

View articletitled, Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

Supplementary data

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Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability

Xinzhu Deng; Jason Tchieu; Daniel S. Higginson; Kuo-Shun Hsu; Regina Feldman; Lorenz Studer; Shai Shaham; Simon N. Powell; Zvi Fuks; Richard Kolesnick

Abstracts

View articletitled, Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability

Supplementary data

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Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer

Alexander Y. Deneka; Meghan C. Kopp; Anna S. Nikonova; Anna V. Gaponova; Anna A. Kiseleva; Harvey H. Hensley; Douglas B. Flieder; Ilya G. Serebriiskii; Erica A. Golemis

Abstracts

View articletitled, Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer

Supplementary data

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Translational Science

Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

Ki Hyun Yoo; Jason J. Tang; Mohammad Abdur Rashid; Chang Hoon Cho; Ana Corujo-Ramirez; Jonghoon Choi; Mun Gyeong Bae; Danielle Brogren; John R. Hawse; Xiaonan Hou; S. John Weroha; Alfredo Oliveros; Lindsey A. Kirkeby; Joseph A. Baur; Mi-Hyeon Jang

Abstracts

View articletitled, Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

Supplementary data

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Population and Prevention Science

Prospective Identification of Elevated Circulating CDCP1 in Patients Years before Onset of Lung Cancer

Sonia Dagnino; Barbara Bodinier; Florence Guida; Karl Smith-Byrne; Dusan Petrovic; Matthew D. Whitaker; Therese Haugdahl Nøst; Claudia Agnoli; Domenico Palli; Carlotta Sacerdote; Salvatore Panico; Rosario Tumino; Matthias B. Schulze; Mikael Johansson; Pekka Keski-Rahkonen; Augustin Scalbert; Paolo Vineis; Mattias Johansson; Torkjel M. Sandanger; Roel C.H. Vermeulen; Marc Chadeau-Hyam

Abstracts

View articletitled, Prospective Identification of Elevated Circulating CDCP1 in Patients Years before Onset of Lung Cancer

Supplementary data

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Journal Archive

Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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Cancer Research

Table of Contents

Breaking Insights

Review

Cancer Research Highlights

Resource Report

Metabolism and Chemical Biology

Molecular Cell Biology

Tumor Biology and Immunology

Translational Science

Population and Prevention Science

Journal Archive

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