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15 June 2021
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Results from clinical trials of EGFR tyrosine kinase inhibitors (TKI) and immunotherapy indicate that the combination remains inadequate for inducing long-term remission. The study by Tu and colleagues demonstrated that early treatment with EGFR TKI afatinib suppressed human CD8+ T lymphocyte proliferation, which rebounded following long-term treatment, suggesting an immunomodulatory effect of afatinib on CD8+ T lymphocytes. Sequential treatment with afatinib then anti-PD1 immunotherapy could enhance therapeutic efficacy by promoting the proliferation of tumor-infiltrating CD8+ T lymphocytes. The image depicts the impact of timing of afatinib treatment on effective killing of tumor cells (red) by T lymphocytes (blue). For details, see article by Tu and colleagues on page 3270.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Genome and Epigenome
Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer
Anthony M. Musolf; Claire L. Simpson; Bilal A. Moiz; Claudio W. Pikielny; Candace D. Middlebrooks; Diptasri Mandal; Mariza de Andrade; Michael D. Cole; Colette Gaba; Ping Yang; Ming You; Yafang Li; Elena Y. Kupert; Marshall W. Anderson; Ann G. Schwartz; Susan M. Pinney; Christopher I. Amos; Joan E. Bailey-Wilson
Molecular Cell Biology
Long Noncoding RNA VESTAR Regulates Lymphangiogenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing VEGFC mRNA Stability
Yali Wang; Weimin Zhang; Wenzhong Liu; Lijie Huang; Yan Wang; Dan Li; Guangchao Wang; Zitong Zhao; Xinming Chi; Yu Xue; Yongmei Song; Xuefeng Liu; Qimin Zhan
EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma
Hoi Wing Leung; Carmen Oi Ning Leung; Eunice Y. Lau; Katherine Po Sin Chung; Etienne H. Mok; Martina Mang Leng Lei; Rainbow Wing Hei Leung; Man Tong; Vincent W. Keng; Cong Ma; Qian Zhao; Irene Oi Lin Ng; Stephanie Ma; Terence K. Lee
Tumor Biology and Immunology
NPM–ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation
Jan M. Pawlicki; David L. Cookmeyer; Damian Maseda; John K. Everett; Fang Wei; Hong Kong; Qian Zhang; Hong Y. Wang; John W. Tobias; David M. Walter; Kelly M. Zullo; Sarah Javaid; Amanda Watkins; Mariusz A. Wasik; Frederic D. Bushman; James L. Riley
Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Adam C. Mueller; Miles Piper; Andrew Goodspeed; Shiv Bhuvane; Jason S. Williams; Shilpa Bhatia; Andy V. Phan; Benjamin Van Court; Kathryn L. Zolman; Brisa Peña; Ayman J. Oweida; Sara Zakem; Cheryl Meguid; Michael W. Knitz; Laurel Darragh; Thomas E. Bickett; Jacob Gadwa; Luisa Mestroni; Matthew R.G. Taylor; Kimberly R. Jordan; Peter Dempsey; M. Scott Lucia; Martin D. McCarter; Marco Del Chiaro; Wells A. Messersmith; Richard D. Schulick; Karyn A. Goodman; Michael J. Gough; Casey S. Greene; James C. Costello; Antonio Galveo Neto; David Lagares; Kirk C. Hansen; Adrie Van Bokhoven; Sana D. Karam
Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD
Hsin-Fang Tu; Chun-Jung Ko; Ching-Tai Lee; Cheng-Fan Lee; Shao-Wei Lan; Hsin-Hsien Lin; Hsin-Ying Lin; Chia-Chi Ku; Der-Yen Lee; I-Chun Chen; Ya-Hui Chuang; Francisco Del Caño-Ochoa; Santiago Ramón-Maiques; Chao-Chi Ho; Ming-Shyue Lee; Geen-Dong Chang
Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung Cancer
Rui Li; Ramin Salehi-Rad; William Crosson; Milica Momcilovic; Raymond J. Lim; Stephanie L. Ong; Zi Ling Huang; Tianhao Zhang; Jensen Abascal; Camelia Dumitras; Zhe Jing; Stacy J. Park; Kostyantyn Krysan; David B. Shackelford; Linh M. Tran; Bin Liu; Steven M. Dubinett
Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors
Lin Wang; Luz M. Londono; Jessica Cowell; Ozge Saatci; Mertkaya Aras; Pelin G. Ersan; Sara Serra; Hong Pei; Renee Clift; Qiping Zhao; Kim B. Phan; Lei Huang; Michael J. LaBarre; Xiaoming Li; H. Michael Shepard; Silvia Deaglio; Joel Linden; Christopher D. Thanos; Ozgur Sahin; Caglar Cekic
Translational Science
Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining
Qin Zhou; Michelle E. Howard; Xinyi Tu; Qian Zhu; Janet M. Denbeigh; Nicholas B. Remmes; Michael G. Herman; Chris J. Beltran; Jian Yuan; Patricia T. Greipp; Judy C. Boughey; Liewei Wang; Neil Johnson; Matthew P. Goetz; Jann N. Sarkaria; Zhenkun Lou; Robert W. Mutter
Author Choice
Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Annamil Alvarez-Trotta; William Guerrant; Luisana Astudillo; Mohini Lahiry; Giulia Diluvio; Elena Shersher; Hugo Kaneku; David J. Robbins; Darren Orton; Anthony J. Capobianco
Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer
Antao Chang; Liang Liu; Justin M. Ashby; Dan Wu; Yanan Chen; Stacey S. O'Neill; Shan Huang; Juan Wang; Guanwen Wang; Dongmei Cheng; Xiaoming Tan; W.J. Petty; Boris C. Pasche; Rong Xiang; Wei Zhang; Peiqing Sun
Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins
Poonam Tewary; Alan D. Brooks; Ya-Ming Xu; E.M. Kithsiri Wijeratne; Ashley L. Babyak; Timothy C. Back; Raj Chari; Christine N. Evans; Curtis J. Henrich; Thomas J. Meyer; Elijah F. Edmondson; Maria T. Prudente de Aquino; Thanigaivelan Kanagasabai; Anil Shanker; A.A. Leslie Gunatilaka; Thomas J. Sayers
Author Choice
Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain
Francesco De Logu; Matilde Marini; Lorenzo Landini; Daniel Souza Monteiro de Araujo; Niccolò Bartalucci; Gabriela Trevisan; Gennaro Bruno; Martina Marangoni; Brian L. Schmidt; Nigel W. Bunnett; Pierangelo Geppetti; Romina Nassini
Author Choice
Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors
Darren C. Phillips; Fritz G. Buchanan; Dong Cheng; Larry R. Solomon; Yu Xiao; John Xue; Stephen K. Tahir; Morey L. Smith; Haichao Zhang; Deborah Widomski; Vivek C. Abraham; Nan Xu; Zhihong Liu; Li Zhou; Enrico DiGiammarino; Xin Lu; Nandini Rudra-Ganguly; Bruce Trela; Susan E. Morgan-Lappe
Convergence and Technologies
Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus
Dale J. Waterhouse; Wladyslaw Januszewicz; Sharib Ali; Rebecca C. Fitzgerald; Massimiliano di Pietro; Sarah E. Bohndiek
The results of this pilot first-in-human clinical trial demonstrate the potential of spectral endoscopy to reveal disease-associated vascular changes and to provide high-contrast delineation of neoplasia in the esophagus.
Corrections
Correction: CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Toshihiro Morita; Yuzo Kodama; Masahiro Shiokawa; Katsutoshi Kuriyama; Saiko Marui; Takeshi Kuwada; Yuko Sogabe; Tomoaki Matsumori; Nobuyuki Kakiuchi; Teruko Tomono; Atsushi Mima; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Yoshihiro Nishikawa; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Takashi Nagasawa; Tsutomu Chiba; Hiroshi Seno
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