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Volume 81, Issue 11
1 June 2021
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    Fructose promotes proliferation and invasiveness of prostate cancer cells in vitro and in vivo. The cover image depicts fructose (light blue) facilitating the transition of a normal prostate epithelial cell (green) into a malignant prostate cancer cell (red). For details, see article by Carreño and colleagues on page 2824.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Insights

Highlights from Recent Cancer Literature
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Obituary

George F. Vande Woude: In Memoriam (1935–2021)
Peter A. Jones
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Review

Roles of the BAP1 Tumor Suppressor in Cell Metabolism
Anna Han; Timothy J. Purwin; Andrew E. Aplin
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Cancer Research Highlights

Loss of Gas7 Is a Key Metastatic Switch in Neuroblastoma
Marie J. Menard
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To Go or Not to Go?—Targeting Tregs Traveling in Tumors
Sanjukta Chakraborty; Roberta Zappasodi
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Controversy and Consensus

Oncometabolites in Cancer: Current Understanding and Challenges
Yang Liu; Chunzhang Yang
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Priority Reports

Dietary Fructose Promotes Prostate Cancer Growth
Daniela V. Carreño; Néstor B. Corro; Javier F. Cerda-Infante; Carolina E. Echeverría; Catalina A. Asencio-Barría; Verónica A. Torres-Estay; Gonzalo A. Mayorga-Weber; Pablo A. Rojas; Loreto P. Véliz; Pedro A. Cisternas; Viviana P. Montecinos; Ignacio F. San Francisco; Manuel A. Varas-Godoy; Paula C. Sotomayor; Maite A. Castro; Francisco J. Nualart; Nibaldo C. Inestrosa; Alejandro S. Godoy
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Genome and Epigenome

Androgen Receptor Regulates CD44 Expression in Bladder Cancer
Joseph L. Sottnik; Lauren Vanderlinden; Molishree Joshi; Ana Chauca-Diaz; Charles Owens; Donna E. Hansel; Colin Sempeck; Debashis Ghosh; Dan Theodorescu
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N6-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis
Feng Chen; Zhuojia Chen; Tao Guan; Yan Zhou; Lichen Ge; Haisheng Zhang; Yingmin Wu; Guan-Min Jiang; Weiling He; Jiexin Li; Hongsheng Wang
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Metabolism and Chemical Biology

DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer
Matteo Lulli; Laura Del Coco; Tommaso Mello; Caecilia Sukowati; Stefania Madiai; Laura Gragnani; Paolo Forte; Francesco Paolo Fanizzi; Antonio Mazzocca; Krista Rombouts; Andrea Galli; Vinicio Carloni
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E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment
Francisco González-Romero; Daniela Mestre; Igor Aurrekoetxea; Colm J. O'Rourke; Jesper B. Andersen; Ashwin Woodhoo; Miguel Tamayo-Caro; Marta Varela-Rey; Marta Palomo-Irigoyen; Beatriz Gómez-Santos; Diego Sáenz de Urturi; Maitane Núñez-García; Juan L. García-Rodríguez; Larraitz Fernández-Ares; Xabier Buqué; Ainhoa Iglesias-Ara; Irantzu Bernales; Virginia Gutierrez De Juan; Teresa C. Delgado; Naroa Goikoetxea-Usandizaga; Richard Lee; Sanjay Bhanot; Igotz Delgado; Maria J. Perugorria; Gaizka Errazti; Lorena Mosteiro; Sonia Gaztambide; Idoia Martinez de la Piscina; Paula Iruzubieta; Javier Crespo; Jesus M. Banales; Maria L. Martínez-Chantar; Luis Castaño; Ana M. Zubiaga; Patricia Aspichueta
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Molecular Cell Biology

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer
Roman M. Chabanon; Daphné Morel; Thomas Eychenne; Léo Colmet-Daage; Ilirjana Bajrami; Nicolas Dorvault; Marlène Garrido; Cornelia Meisenberg; Andrew Lamb; Carine Ngo; Suzanna R. Hopkins; Theodoros I. Roumeliotis; Samuel Jouny; Clémence Hénon; Asuka Kawai-Kawachi; Clémence Astier; Asha Konde; Elaine Del Nery; Christophe Massard; Stephen J. Pettitt; Raphaël Margueron; Jyoti S. Choudhary; Geneviève Almouzni; Jean-Charles Soria; Eric Deutsch; Jessica A. Downs; Christopher J. Lord; Sophie Postel-Vinay

This study demonstrates that PARP and ATR inhibitors are synthetic lethal with the loss of PBRM1, a PBAF-specific subunit, thus providing the rationale for assessing these inhibitors in patients with PBRM1-defective cancer.

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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells
Constandina E. O'Connell; Alex Vassilev
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LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells
Shujun Han; Yuwei Yan; Yibo Ren; Yiming Hu; Yan Wang; Lei Chen; Zhe Zhi; Yan Zheng; Yongping Shao; Jiankang Liu
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Author Choice
A Fusion Transcription Factor–Driven Cancer Progresses to a Fusion-Independent Relapse via Constitutive Activation of a Downstream Transcriptional Target
Salah Boudjadi; Puspa Raj Pandey; Bishwanath Chatterjee; Thanh Hung Nguyen; Wenyue Sun; Frederic G. Barr
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STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer
Ana P. Kutschat; Feda H. Hamdan; Xin Wang; Alexander Q. Wixom; Zeynab Najafova; Christine S. Gibhardt; Waltraut Kopp; Jochen Gaedcke; Philipp Ströbel; Volker Ellenrieder; Ivan Bogeski; Elisabeth Hessmann; Steven A. Johnsen
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Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation–Induced DNA Damage and Melanoma Susceptibility
David de Semir; Vladimir Bezrookove; Mehdi Nosrati; Altaf A. Dar; James R. Miller, III; Stanley P. Leong; Kevin B. Kim; Wilson Liao; Liliana Soroceanu; Sean McAllister; Robert J. Debs; Dirk Schadendorf; Sancy A. Leachman; James E. Cleaver; Mohammed Kashani-Sabet
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Tumor Biology and Immunology

GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer
Alexandra Adamczyk; Eva Pastille; Jan Kehrmann; Vivian P. Vu; Robert Geffers; Marie-Hélène Wasmer; Stefan Kasper; Martin Schuler; Christian M. Lange; Beat Muggli; Tilman T. Rau; Diana Klein; Wiebke Hansen; Philippe Krebs; Jan Buer; Astrid M. Westendorf
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Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models
Joseph R. Campbell; Bryan R. McDonald; Paul B. Mesko; Nathan O. Siemers; Priti B. Singh; Mark Selby; Tim W. Sproul; Alan J. Korman; Logan M. Vlach; Jeff Houser; Sharmila Sambanthamoorthy; Kai Lu; Sandra V. Hatcher; Jack Lohre; Renu Jain; Ruth Y. Lan
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GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma
Zhiwei Dong; Kok Siong Yeo; Gonzalo Lopez; Cheng Zhang; Erin N. Dankert Eggum; Jo Lynne Rokita; Choong Yong Ung; Taylor M. Levee; Zuag Paj Her; Cassie J. Howe; Xiaonan Hou; Janine H. van Ree; Shuai Li; Shuning He; Ting Tao; Karen Fritchie; Jorge Torres-Mora; Julia S. Lehman; Alexander Meves; Gina L. Razidlo; Komal S. Rathi; S. John Weroha; A. Thomas Look; Jan M. van Deursen; Hu Li; Jennifer J. Westendorf; John M. Maris; Shizhen Zhu
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Epigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women
Fei Xing; Dan Zhao; Shih-Ying Wu; Abhishek Tyagi; Kerui Wu; Sambad Sharma; Yin Liu; Ravindra Deshpande; Yuezhu Wang; Jacob Cleary; Lance D. Miller; Amar G. Chittiboyina; Chinni Yalamanchili; Yin-Yuan Mo; Kounosuke Watabe
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Author Choice
Mesothelin-Specific CAR T Cells Target Ovarian Cancer
Esther Schoutrop; Ibrahim El-Serafi; Thomas Poiret; Ying Zhao; Okan Gultekin; Rui He; Lidia Moyano-Galceran; Joseph W. Carlson; Kaisa Lehti; Moustapha Hassan; Isabelle Magalhaes; Jonas Mattsson
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A TNFR2–hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells
Yan Meng; Qiudong Zhao; Liwei An; Shi Jiao; Rong Li; Yan Sang; Jianping Liao; Pingping Nie; Fuping Wen; Junyi Ju; Zhaocai Zhou; Lixin Wei
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Translational Science

Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance
Xu Zhang; Tapan K. Maity; Karen E. Ross; Yue Qi; Constance M. Cultraro; Meriam Bahta; Stephanie Pitts; Meghana Keswani; Shaojian Gao; Khoa Dang P. Nguyen; Julie Cowart; Fatos Kirkali; Cathy Wu; Udayan Guha
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SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243
Yasuhisa Murai; Ukhyun Jo; Junko Murai; Lisa M. Jenkins; Shar-Yin N. Huang; Sirisha Chakka; Lu Chen; Ken Cheng; Shinsaku Fukuda; Naoko Takebe; Yves Pommier
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Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
Hui Qin Wang; Iain J. Mulford; Fiona Sharp; Jinsheng Liang; Sema Kurtulus; Gina Trabucco; David S. Quinn; Tyler A. Longmire; Nidhi Patel; Roshani Patil; Matthew D. Shirley; Yan Chen; Hao Wang; David A. Ruddy; Claire Fabre; Juliet A. Williams; Peter S. Hammerman; Jennifer Mataraza; Barbara Platzer; Ensar Halilovic
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Rapid Depletion of Intratumoral Regulatory T Cells Induces Synchronized CD8 T- and NK-cell Activation and IFNγ-Dependent Tumor Vessel Regression
Yutaka Kurebayashi; Colleen P. Olkowski; Kelly C. Lane; Olga V. Vasalatiy; Biying C. Xu; Ryuhei Okada; Aki Furusawa; Peter L. Choyke; Hisataka Kobayashi; Noriko Sato
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Inhibition of the FACT Complex Targets Aberrant Hedgehog Signaling and Overcomes Resistance to Smoothened Antagonists
Jialin Mo; Fang Liu; Xi Sun; Hongting Huang; Kezhe Tan; Xiaojing Zhao; Rui Li; Wenyan Jiang; Yi Sui; Xiaosong Chen; Kunwei Shen; Liye Zhang; Jie Ma; Kewen Zhao; Yujie Tang
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CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for FGFR1-Amplified Lung Cancer
Zhang Yang; Shun-Qing Liang; Haitang Yang; Duo Xu; Rémy Bruggmann; Yanyun Gao; Haibin Deng; Sabina Berezowska; Sean R.R. Hall; Thomas M. Marti; Gregor J. Kocher; Qinghua Zhou; Ralph A. Schmid; Ren-Wang Peng
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Population and Prevention Science

Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3
Evelina Mocci; Prosenjit Kundu; William Wheeler; Alan A. Arslan; Laura E. Beane-Freeman; Paige M. Bracci; Paul Brennan; Federico Canzian; Mengmeng Du; Steven Gallinger; Graham G. Giles; Phyllis J. Goodman; Charles Kooperberg; Loic Le Marchand; Rachel E. Neale; Xiao-Ou Shu; Kala Visvanathan; Emily White; Wei Zheng; Demetrius Albanes; Gabriella Andreotti; Ana Babic; William R. Bamlet; Sonja I. Berndt; Amanda L. Blackford; Bas Bueno-de-Mesquita; Julie E. Buring; Daniele Campa; Stephen J. Chanock; Erica J. Childs; Eric J. Duell; Charles S. Fuchs; J. Michael Gaziano; Edward L. Giovannucci; Michael G. Goggins; Patricia Hartge; Manal M. Hassan; Elizabeth A. Holly; Robert N. Hoover; Rayjean J. Hung; Robert C. Kurtz; I-Min Lee; Núria Malats; Roger L. Milne; Kimmie Ng; Ann L. Oberg; Salvatore Panico; Ulrike Peters; Miquel Porta; Kari G. Rabe; Elio Riboli; Nathaniel Rothman; Ghislaine Scelo; Howard D. Sesso; Debra T. Silverman; Victoria L. Stevens; Oliver Strobel; Ian M. Thompson, Jr; Anne Tjonneland; Antonia Trichopoulou; Stephen K. Van Den Eeden; Jean Wactawski-Wende; Nicolas Wentzensen; Lynne R. Wilkens; Herbert Yu; Fangcheng Yuan; Anne Zeleniuch-Jacquotte; Laufey T. Amundadottir; Donghui Li; Eric J. Jacobs; Gloria M. Petersen; Brian M. Wolpin; Harvey A. Risch; Peter Kraft; Nilanjan Chatterjee; Alison P. Klein; Rachael Stolzenberg-Solomon
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Corrections

Correction: Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Larysa V. Yuzefovych; Andrea G. Kahn; Michele A. Schuler; Lars Eide; Ritu Arora; Glenn L. Wilson; Ming Tan; Lyudmila I. Rachek
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Correction: Epigenetic Regulation of NAMPT by NAMPT-AS Drives Metastatic Progression in Triple-Negative Breast Cancer
Hanwen Zhang; Ning Zhang; Ying Liu; Peng Su; Yiran Liang; Yaming Li; Xiaolong Wang; Tong Chen; Xiaojin Song; Yuting Sang; Yi Duan; Jiashu Zhang; Lijuan Wang; Bing Chen; Wenjing Zhao; Haiyang Guo; Zhaojian Liu; Guohong Hu; Qifeng Yang
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