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15 May 2021
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Cover Image
POT1 is a member of the shelterin complex, which binds telomeres and regulates their extension. Germline mutations in POT1 confer increased risk to a host of cancers, including glioma. Using native mouse models of glioma, it was found that deletion of POT had sex-specific effects on tumorigenesis, with females exhibiting decreased survival compared to males. Transcriptomic analysis and immunostaining validation studies revealed sex-specific changes in immune populations, with females exhibiting decreased expression of microglia/macrophage markers. Artwork by Emma Vidal. For details, see article by Jalali and colleagues on page 2703.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Genome and Epigenome
Author Choice
Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers
Fazlur Rahman Talukdar; Sheila C. Soares Lima; Rita Khoueiry; Ruhina Shirin Laskar; Cyrille Cuenin; Bruna Pereira Sorroche; Anne-Claire Boisson; Behnoush Abedi-Ardekani; Christine Carreira; Diana Menya; Charles P. Dzamalala; Mathewos Assefa; Abraham Aseffa; Vera Miranda-Gonçalves; Carmen Jerónimo; Rui M. Henrique; Ramin Shakeri; Reza Malekzadeh; Nagla Gasmelseed; Mona Ellaithi; Nitin Gangane; Daniel R.S. Middleton; Florence Le Calvez-Kelm; Akram Ghantous; Maria Leon Roux; Joachim Schüz; Valerie McCormack; M. Iqbal Parker; Luis Felipe Ribeiro Pinto; Zdenko Herceg
Metabolism and Chemical Biology
Molecular Cell Biology
MYC-Activated LncRNA MNX1-AS1 Promotes the Progression of Colorectal Cancer by Stabilizing YB1
Qi-Nian Wu; Xiao-Jing Luo; Jia Liu; Yun-Xin Lu; Yun Wang; Jingjing Qi; Ze-Xian Liu; Qi-Tao Huang; Ze-Kun Liu; Jia-Bin Lu; Ying Jin; Heng-Ying Pu; Pei-Shan Hu; Jia-Bo Zheng; Zhao-Lei Zeng; Huai-Qiang Ju; Dan Xie; Qi Zhao; Ruihua Xu
Author Choice
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7
Jingnan Pi; Wen Wang; Ming Ji; Xiaoshuang Wang; Xueju Wei; Jing Jin; Tao Liu; Jiaqi Qiang; Zhihong Qi; Feng Li; Yue Liu; Yanni Ma; Yanmin Si; Yue Huo; Yufeng Gao; Yiying Chen; Lei Dong; Rui Su; Jianjun Chen; Shuan Rao; Ping Yi; Shuyang Yu; Fang Wang; Jia Yu
CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia
Husheng Ding; Nicole D. Vincelette; Cordelia D. McGehee; Mira A. Kohorst; Brian D. Koh; Annapoorna Venkatachalam; X. Wei Meng; Paula A. Schneider; Karen S. Flatten; Kevin L. Peterson; Cristina Correia; Sun-Hee Lee; Mrinal Patnaik; Jonathan A. Webster; Gabriel Ghiaur; B. Douglas Smith; Judith E. Karp; Keith W. Pratz; Hu Li; Larry M. Karnitz; Scott H. Kaufmann
Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells
Mohamad Assi; Younes Achouri; Axelle Loriot; Nicolas Dauguet; Hajar Dahou; Jonathan Baldan; Maxime Libert; Jean S. Fain; Carmen Guerra; Luc Bouwens; Mariano Barbacid; Frédéric P. Lemaigre; Patrick Jacquemin
Tumor Biology and Immunology
MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
Bin Yang; Xi Li; Yu Fu; Ensong Guo; Youqiong Ye; Fuxia Li; Si Liu; Rourou Xiao; Chen Liu; Funian Lu; Jia Huang; Tianyu Qin; Leng Han; Guang Peng; Gordon B. Mills; Chaoyang Sun; Gang Chen
Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy
Carla Frau; Catherine Jamard; Gaspard Delpouve; Gabriela D.A. Guardia; Christelle Machon; Camilla Pilati; Clémentine Le Nevé; Pierre Laurent-Puig; Jérôme Guitton; Pedro A.F. Galante; Luiz O. Penalva; Jean-Noel Freund; Christelle de la Fouchardiere; Michelina Plateroti
Author Choice
Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome
Xi Wang; Yiqun Jia; Liling Wen; Wenxin Mu; Xianrui Wu; Tao Liu; Xiangqi Liu; Juan Fang; Yizhao Luan; Ping Chen; Jinlong Gao; Ky-Anh Nguyen; Jun Cui; Gucheng Zeng; Ping Lan; Qianming Chen; Bin Cheng; Zhi Wang
Translational Science
The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells
Prashant V. Bommi; Charles M. Bowen; Laura Reyes-Uribe; Wenhui Wu; Hiroyuki Katayama; Pedro Rocha; Edwin R. Parra; Alejandro Francisco-Cruz; Zuhal Ozcan; Elena Tosti; Jason A. Willis; Hong Wu; Melissa W. Taggart; Jared K. Burks; Patrick M. Lynch; Winfried Edelmann; Paul A. Scheet; Ignacio I. Wistuba; Krishna M. Sinha; Samir M. Hanash; Eduardo Vilar
Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells
Anniina Färkkilä; Alfredo Rodríguez; Jaana Oikkonen; Doga C. Gulhan; Huy Nguyen; Julieta Domínguez; Sandra Ramos; Caitlin E. Mills; Fernando Pérez-Villatoro; Jean-Bernard Lazaro; Jia Zhou; Connor S. Clairmont; Lisa A. Moreau; Peter J. Park; Peter K. Sorger; Sampsa Hautaniemi; Sara Frias; Alan D. D'Andrea
Author Choice
“3G” Trial: An RNA Editing Signature to Guide Gastric Cancer Chemotherapy
Omer An; Yangyang Song; Xinyu Ke; Jimmy Bok-Yan So; Raghav Sundar; Henry Yang; Sun Young Rha; Ming Hui Lee; Su Ting Tay; Xuewen Ong; Angie Lay Keng Tan; Matthew Chau Hsien Ng; Erwin Tantoso; Leilei Chen; Patrick Tan; Wei Peng Yong; Singapore Gastric Cancer Consortium (SGCC)
Population and Prevention Science
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