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1 January 2021
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Cover Image
Cover Image
Quantitative analysis of lung metastases in mouse cancer models can be troublesome, often requiring laborious tissue sectioning. In a B16F10 melanoma cell colonization model, cells were injected into tail veins of mice and their lungs collected after two weeks. The left lung lobes were processed, optically cleared, and scanned in 3D using optical projection tomography. This provided a novel method to accurately quantify the volume and number of melanoma cell colonies from whole mouse lungs. For details, see the article by Kapiainen and colleagues on page 129. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Obituary
Reviews
Cancer Research Highlights
Genome and Epigenome
PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress ApcMin-Triggered Intestinal Tumor Formation
Alexandra L. Farrall; Matthias Lienhard; Christina Grimm; Heiner Kuhl; Susanna H.M. Sluka; Marta Caparros; Jiri Forejt; Bernd Timmermann; Ralf Herwig; Bernhard G. Herrmann; Markus Morkel
Molecular Cell Biology
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone
Abhisha Sawant Dessai; Mayrel Palestino Dominguez; Uan-I Chen; John Hasper; Christian Prechtl; Cuijuan Yu; Eriko Katsuta; Tao Dai; Bokai Zhu; Sung Yun Jung; Nagireddy Putluri; Kazuaki Takabe; Xiang H.-F. Zhang; Bert W. O'Malley; Subhamoy Dasgupta
NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression
Ga-Young Jeong; Mi Kyung Park; Hee-Joo Choi; Hee Woon An; Young-Un Park; Hyung-Jun Choi; Jin Park; Hyung-Yong Kim; Taekwon Son; Ho Lee; Kyueng-Whan Min; Young-Ha Oh; Jeong-Yeon Lee; Gu Kong
Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness
Koelina Ganguly; Shiv Ram Krishn; Satyanarayana Rachagani; Rahat Jahan; Ashu Shah; Palanisamy Nallasamy; Sanchita Rauth; Pranita Atri; Jesse L. Cox; Ramesh Pothuraju; Lynette M. Smith; Sudhua Ayala; Christopher Evans; Moorthy P. Ponnusamy; Sushil Kumar; Sukhwinder Kaur; Surinder K. Batra
Design and Functional Validation of a Mutant Variant of the LncRNA HOTAIR to Counteract Snail Function in Epithelial-to-Mesenchymal Transition
Cecilia Battistelli; Sabrina Garbo; Veronica Riccioni; Claudia Montaldo; Laura Santangelo; Andrea Vandelli; Raffaele Strippoli; Gian Gaetano Tartaglia; Marco Tripodi; Carla Cicchini
Tumor Biology and Immunology
The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice
Emmi Kapiainen; Minna K. Kihlström; Riikka Pietilä; Mika Kaakinen; Veli-Pekka Ronkainen; Hongmin Tu; Anne Heikkinen; Raman Devarajan; Ilkka Miinalainen; Anna Laitakari; Mohammadhassan Ansarizadeh; Qin Zhang; Gong-Hong Wei; Lloyd Ruddock; Taina Pihlajaniemi; Harri Elamaa; Lauri Eklund
Author Choice
Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer
Changxin Wan; Matthew P. Keany; Han Dong; Linah F. Al-Alem; Unnati M. Pandya; Suzan Lazo; Karsten Boehnke; Katherine N. Lynch; Rui Xu; Dominique T. Zarrella; Shengqing Gu; Paloma Cejas; Klothilda Lim; Henry W. Long; Kevin M. Elias; Neil S. Horowitz; Colleen M. Feltmate; Michael G. Muto; Michael J. Worley, Jr; Ross S. Berkowitz; Ursula A. Matulonis; Marisa R. Nucci; Christopher P. Crum; Bo R. Rueda; Myles Brown; Xiaole Shirley Liu; Sarah J. Hill
Translational Science
Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma
Atreyi Dasgupta; Laura Sierra; Susan V. Tsang; Lyazat Kurenbekova; Tajhal Patel; Kimal Rajapakse; Ryan L. Shuck; Nino Rainusso; Yosef Landesman; Thaddeus Unger; Cristian Coarfa; Jason T. Yustein
Convergence and Technologies
Acknowledgment to Reviewers
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