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15 March 2020
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A new, therapeutically actionable molecular pathway that can inhibit distant metastasis has been reported by Eckhardt and colleagues. They report the ability of canonical BMP4-Smad signaling to induce a "stop metastasis" gene signature, with the induction of Smad7 in breast tumors acting as a critical mediator in the prevention of cancer dissemination. Restored BMP4 expression, or neoadjuvant recombinant BMP4 therapy, inhibited spontaneous metastasis of mammary tumors in a Smad7-dependent pathway, linked to the ability of BMP4 and Smad7 to induce anoikis in disseminating breast cancer cells. Clinically, breast tumors that express BMP4 and/or Smad7 are linked to good prognostic outcome. The cover art depicts an immunohistochemical stain for BMP4 in a breast cancer sample, false-colored in a homage to "pop art," as BMP4-Smad7 elicits anchorage-independent apoptosis (anoikis). For details, see article by Eckhardt and colleagues on page 1304.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Cancer Research Highlights
Genome and Epigenome
Metabolism and Chemical Biology
Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma
Elizabeth C. Randall; Begoña G.C. Lopez; Sen Peng; Michael S. Regan; Walid M. Abdelmoula; Sankha S. Basu; Sandro Santagata; Haejin Yoon; Marcia C. Haigis; Jeffrey N. Agar; Nhan L. Tran; William F. Elmquist; Forest M. White; Jann N. Sarkaria; Nathalie Y.R. Agar
Increased Tumor Penetration of Single-Domain Antibody–Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models
Ian Nessler; Eshita Khera; Steven Vance; Anna Kopp; Qifeng Qiu; Thomas A. Keating; Adnan O. Abu-Yousif; Thomas Sandal; James Legg; Lorraine Thompson; Normann Goodwin; Greg M. Thurber
Molecular Cell Biology
BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial–Mesenchymal Transition
Masaki Sato; Mitsuyo Matsumoto; Yuriko Saiki; Mahabub Alam; Hironari Nishizawa; Masahiro Rokugo; Andrey Brydun; Shinji Yamada; Mika K. Kaneko; Ryo Funayama; Mamoru Ito; Yukinari Kato; Keiko Nakayama; Michiaki Unno; Kazuhiko Igarashi
Author Choice
The MEK5–ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer
Sandra Cristea; Garry L. Coles; Daniel Hornburg; Maya Gershkovitz; Julia Arand; Siqi Cao; Triparna Sen; Stuart C. Williamson; Jun W. Kim; Alexandros P. Drainas; Andrew He; Laurent Le Cam; Lauren Averett Byers; Michael P. Snyder; Kévin Contrepois; Julien Sage
Tumor Biology and Immunology
Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Marleen Gloger; Lutz Menzel; Michael Grau; Anne-Clemence Vion; Ioannis Anagnostopoulos; Myroslav Zapukhlyak; Kerstin Gerlach; Thomas Kammertöns; Thomas Hehlgans; Maria Zschummel; Georg Lenz; Holger Gerhardt; Uta E. Höpken; Armin Rehm
Population and Prevention Science
Author Choice
A Prospective Analysis of Circulating Plasma Metabolites Associated with Ovarian Cancer Risk
Oana A. Zeleznik; A. Heather Eliassen; Peter Kraft; Elizabeth M. Poole; Bernard A. Rosner; Sarah Jeanfavre; Amy A. Deik; Kevin Bullock; Daniel S. Hitchcock; Julian Avila-Pacheco; Clary B. Clish; Shelley S. Tworoger
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