A new, therapeutically actionable molecular pathway that can inhibit distant metastasis has been reported by Eckhardt and colleagues. They report the ability of canonical BMP4-Smad signaling to induce a "stop metastasis" gene signature, with the induction of Smad7 in breast tumors acting as a critical mediator in the prevention of cancer dissemination. Restored BMP4 expression, or neoadjuvant recombinant BMP4 therapy, inhibited spontaneous metastasis of mammary tumors in a Smad7-dependent pathway, linked to the ability of BMP4 and Smad7 to induce anoikis in disseminating breast cancer cells. Clinically, breast tumors that express BMP4 and/or Smad7 are linked to good prognostic outcome. The cover art depicts an immunohistochemical stain for BMP4 in a breast cancer sample, false-colored in a homage to "pop art," as BMP4-Smad7 elicits anchorage-independent apoptosis (anoikis). For details, see article by Eckhardt and colleagues on page 1304.