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15 February 2020
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Cover Image
Cover Image
Shining a light on cholangiocarcinoma. NanoString imaging highlights spatial interactions between tumor cells (green), T cells (red), and stromal cells (yellow) within the cholangiocarcinoma tumor microenvironment. The recruitment of immune cells, activation of stromal cells, and proliferation of epithelial cells is a feature of cholangiocarcinoma. Dysregulation of WNT and NOTCH signaling pathways is critical to proliferation and invasion and occurs through activation of the PRH transcription factor, which is thereby able to increase epithelial-mesenchymal plasticity and transit through the cell cycle. Image collected by Dr. Jingjing Gong (NanoString), Dr. Isioma Egbuniwe (histopathologist, University of Nottingham, United Kingdom), Professor K. Gaston (University of Nottingham), and Dr. P.S. Jayaraman (University of Birmingham, United Kingdom). For details, see article by Kitchen and colleagues on page 757. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Controversy and Consensus
Metabolism and Chemical Biology
Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells
Mihály Cserepes; Dóra Türk; Szilárd Tóth; Veronika F.S. Pape; Anikó Gaál; Melinda Gera; Judit E. Szabó; Nóra Kucsma; György Várady; Beáta G. Vértessy; Christina Streli; Pál T. Szabó; Jozsef Tovari; Norbert Szoboszlai; Gergely Szakács
A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis
Kun Liao; Shuye Deng; Liyan Xu; Wenfeng Pan; Shiyu Yang; Fufu Zheng; Xingui Wu; Hongrong Hu; Zhijun Liu; Junhang Luo; Rui Zhang; Dong-Ming Kuang; Jiajun Dong; Yi Wu; Hui Zhang; Penghui Zhou; Jin-Xin Bei; Yang Xu; Yin Ji; Peng Wang; Huai-Qiang Ju; Rui-Hua Xu; Bo Li
Molecular Cell Biology
Tumor Biology and Immunology
A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition
Philip Kitchen; Ka Ying Lee; Danielle Clark; Nikki Lau; Jomnarong Lertsuwan; Anyaporn Sawasdichai; Jutamaad Satayavivad; Sebastian Oltean; Simon Afford; Kevin Gaston; Padma-Sheela Jayaraman
IL6/STAT3 Signaling Orchestrates Premetastatic Niche Formation and Immunosuppressive Traits in Lung
Bo Jing; Tong Wang; Beibei Sun; Jianhua Xu; Dongliang Xu; Yueling Liao; Hongyong Song; Wenzheng Guo; Kaimi Li; Min Hu; Siwei Zhang; Jing Ling; Yanbin Kuang; Tuo Zhang; Binhua P. Zhou; Feng Yao; Jiong Deng
Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity
Johannes C. Melms; Sreeram Vallabhaneni; Caitlin E. Mills; Clarence Yapp; Jia-Yun Chen; Eugenio Morelli; Patricia Waszyk; Sushil Kumar; Derrick Deming; Nienke Moret; Steven Rodriguez; Kartik Subramanian; Meri Rogava; Adam N.R. Cartwright; Adrienne Luoma; Shaolin Mei; Titus J. Brinker; David M. Miller; Alexander Spektor; Dirk Schadendorf; Nicolo Riggi; Kai W. Wucherpfennig; Peter K. Sorger; Benjamin Izar
Translational Science
Author Choice
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death
Johannes Ommer; Joanna L. Selfe; Marco Wachtel; Eleanor M. O'Brien; Dominik Laubscher; Michaela Roemmele; Stephanie Kasper; Olivier Delattre; Didier Surdez; Gemma Petts; Anna Kelsey; Janet Shipley; Beat W. Schäfer
Combined MEK and PI3K/p110β Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features
Miriam Marqués; Robin Tranchant; Blanca Risa-Ebrí; María L. Suárez-Solís; Luis C. Fernández; Enrique Carrillo-de-Santa-Pau; Natalia del Pozo; Jaime Martínez de Villarreal; Clément Meiller; Yves Allory; Yuna Blum; Christine Pirker; Balazs Hegedus; Simon T. Barry; Amancio Carnero; Walter Berger; Didier Jean; Francisco X. Real
Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Kevin W. McCool; Zachary T. Freeman; Yali Zhai; Rong Wu; Kevin Hu; Chia-Jen Liu; Scott A. Tomlins; Eric R. Fearon; Brian Magnuson; Rork Kuick; Kathleen R. Cho
Convergence and Technologies
Resource Report
Corrections
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