Ovarian cancer cells rely on differential signaling of EGFR/ERBB2- or FOXM1-activated pathways when cancer cells become spheroids or when they attach to the mesothelium on distant organs, respectively. Using immunofluorescence, the authors photographed GFP-labeled ovarian cancer cells (green) that were grown on the RFP-labeled mesothelial cells (red). Ovarian cancer cells were then sorted, and gene expression signatures for both adherent and nonadherent cells were determined. The authors further identified that ZEB1 is an important regulator of EGFR, ERBB2, and FOXM1, which are critical for the transition between adherent and nonadherent forms of cells. For details, see the article by Parashar and colleagues on page 5554.