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Volume 80, Issue 22
15 November 2020
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    Cover Image

    issue cover
    Stored lipid droplets promote pancreatic tumor cell migration. The image shows BxPC-3 pancreatic tumor cells migrating in a wound healing assay following loading with oleic acid. Lipid droplets (yellow, BODIPY-FL-C12), actin (red, phalloidin), and nuclei (blue). For details, see article by Rozeveld and colleagues on page 4932.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Insights

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

Relationships between Breast Feeding and Breast Cancer Subtypes: Lessons Learned from Studies in Humans and in Mice
Christine B. Ambrosone; Michael J. Higgins
View articletitled, Relationships between Breast Feeding and Breast Cancer Subtypes: Lessons Learned from Studies in Humans and in Mice
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Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell–Cell Interactions in Tumor Progression
Adam Lauko; Zhaomei Mu; David H. Gutmann; Ulhas P. Naik; Justin D. Lathia
View articletitled, Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell–Cell Interactions in Tumor Progression
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Cancer Research Highlights

Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
Jennifer Man; Marina Pajic; Anthony M. Joshua
View articletitled, Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
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Controversy and Consensus

Field Carcinogenesis in Cancer Evolution: What the Cell Is Going On?
Ansam Sinjab; Guangchun Han; Linghua Wang; Humam Kadara
View articletitled, Field Carcinogenesis in Cancer Evolution: What the Cell Is Going On?
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Genome and Epigenome

Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer
Joseph D. Schonhoft; Jimmy L. Zhao; Adam Jendrisak; Emily A. Carbone; Ethan S. Barnett; Melanie A. Hullings; Audrey Gill; Ramsay Sutton; Jerry Lee; Angel E. Dago; Mark Landers; Samuel F. Bakhoum; Yipeng Wang; Mithat Gonen; Ryan Dittamore; Howard I. Scher
View articletitled, Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer
Supplementary data
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Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer
Elena Beketova; Shuyi Fang; Jake L. Owens; Sheng Liu; Xufeng Chen; Qingfu Zhang; Andrew M. Asberry; Xuehong Deng; Jonathan Malola; Jiaoti Huang; Chenglong Li; Roberto Pili; Bennett D. Elzey; Timothy L. Ratliff; Jun Wan; Chang-Deng Hu
View articletitled, Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer
Supplementary data
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Chromothripsis in Human Breast Cancer
Michiel Bolkestein; John K.L. Wong; Verena Thewes; Verena Körber; Mario Hlevnjak; Shaymaa Elgaafary; Markus Schulze; Felix K.F. Kommoss; Hans-Peter Sinn; Tobias Anzeneder; Steffen Hirsch; Frauke Devens; Petra Schröter; Thomas Höfer; Andreas Schneeweiss; Peter Lichter; Marc Zapatka; Aurélie Ernst
View articletitled, Chromothripsis in Human Breast Cancer
Supplementary data
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Metabolism and Chemical Biology

KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL
Cody N. Rozeveld; Katherine M. Johnson; Lizhi Zhang; Gina L. Razidlo
View articletitled, KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL
Supplementary data
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Molecular Cell Biology

Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Naoka Tamura; Nadeem Shaikh; Daniel Muliaditan; Tanya N. Soliman; Jennifer R. McGuinness; Eleni Maniati; Daniela Moralli; Mary-Anne Durin; Catherine M. Green; Frances R. Balkwill; Jun Wang; Kit Curtius; Sarah E. McClelland
View articletitled, Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Supplementary data
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Noncanonical IL6 Signaling-Mediated Activation of YAP Regulates Cell Migration and Invasion in Ovarian Clear Cell Cancer
Walid J. Azar; Elizabeth L. Christie; Chris Mitchell; David S. Liu; George Au-Yeung; David D.L. Bowtell
View articletitled, Noncanonical IL6 Signaling-Mediated Activation of YAP Regulates Cell Migration and Invasion in Ovarian Clear Cell Cancer
Supplementary data
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A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking
Emily B. Harrison; Alessandro Porrello; Brittany M. Bowman; Adam R. Belanger; Gabriella Yacovone; Salma H. Azam; Ian A. Windham; Subrata K. Ghosh; Menglin Wang; Nicholas Mckenzie; Trent A. Waugh; Amanda E.D. Van Swearingen; Stephanie M. Cohen; Devon G. Allen; Tyler J. Goodwin; Teresa Mascenik; James E. Bear; Sarah Cohen; Scott H. Randell; Pierre P. Massion; Michael B. Major; Leaf Huang; Chad V. Pecot
View articletitled, A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking
Supplementary data
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Tumor Biology and Immunology

Author Choice
Futibatinib Is a Novel Irreversible FGFR 1–4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors
Hiroshi Sootome; Hidenori Fujita; Kenjiro Ito; Hiroaki Ochiiwa; Yayoi Fujioka; Kimihiro Ito; Akihiro Miura; Takeshi Sagara; Satoru Ito; Hirokazu Ohsawa; Sachie Otsuki; Kaoru Funabashi; Masakazu Yashiro; Kenichi Matsuo; Kazuhiko Yonekura; Hiroshi Hirai
View articletitled, Futibatinib Is a Novel Irreversible FGFR 1–4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors
Supplementary data
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Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation–Specific and HIF-Dependent Manner
Mahelet Mamo; I. Chae Ye; Josh W. DiGiacomo; Je Yeon Park; Bradley Downs; Daniele M. Gilkes
View articletitled, Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation–Specific and HIF-Dependent Manner
Supplementary data
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β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism
Mirella Belleri; Giuseppe Paganini; Daniela Coltrini; Roberto Ronca; Daniela Zizioli; Michela Corsini; Andrea Barbieri; Elisabetta Grillo; Stefano Calza; Roberto Bresciani; Eugenio Maiorano; Mauro G. Mastropasqua; Tiziana Annese; Arianna Giacomini; Domenico Ribatti; Josefina Casas; Thierry Levade; Gemma Fabrias; Marco Presta
View articletitled, β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism
Supplementary data
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Local Targeting of NAD+ Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma
Ming Li; Ameya R. Kirtane; Juri Kiyokawa; Hiroaki Nagashima; Aaron Lopes; Zain A. Tirmizi; Christine K. Lee; Giovanni Traverso; Daniel P. Cahill; Hiroaki Wakimoto
View articletitled, Local Targeting of NAD<sup>+</sup> Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma
Supplementary data
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EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway
Hao-Nien Chen; Kang-Hao Liang; Jun-Kai Lai; Chun-Hsin Lan; Mei-Ying Liao; Shao-Hsi Hung; Yi-Ting Chuang; Kai-Chi Chen; William Wei-Fu Tsuei; Han-Chung Wu
View articletitled, EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway
Supplementary data
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FGFR1 Is Critical for RBL2 Loss–Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer
Kee-Beom Kim; Youngchul Kim; Christopher J. Rivard; Dong-Wook Kim; Kwon-Sik Park
View articletitled, FGFR1 Is Critical for RBL2 Loss–Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer
Supplementary data
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Translational Science

CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade
Justin M. Drerup; Yilun Deng; Sri Lakshmi Pandeswara; Álvaro S. Padrón; Ryan M. Reyes; Xinyue Zhang; Jenny Mendez; Aijie Liu; Curtis A. Clark; Wanjiao Chen; José R. Conejo-Garcia; Vincent Hurez; Harshita Gupta; Tyler J. Curiel
View articletitled, CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade
Supplementary data
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A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer
Lisa Dwane; Aisling E. O'Connor; Sudipto Das; Bruce Moran; Laoighse Mulrane; Adan Pinto-Fernandez; Elspeth Ward; Anna M. Blümel; Brenton L. Cavanagh; Brian Mooney; Annette M. Dirac; Karin Jirström; Benedikt M. Kessler; Tríona Ní Chonghaile; René Bernards; William M. Gallagher; Darran P. O'Connor
View articletitled, A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer
Supplementary data
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Author Choice
Generalized Additive Mixed Modeling of Longitudinal Tumor Growth Reduces Bias and Improves Decision Making in Translational Oncology
William F. Forrest; Bruno Alicke; Oleg Mayba; Magdalena Osinska; Michal Jakubczak; Pawel Piatkowski; Lech Choniawko; Alice Starr; Stephen E. Gould
View articletitled, Generalized Additive Mixed Modeling of Longitudinal Tumor Growth Reduces Bias and Improves Decision Making in Translational Oncology
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Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment
Elavarasan Subramani; Marina Radoul; Chloe Najac; Georgios Batsios; Abigail R. Molloy; Donghyun Hong; Anne Marie Gillespie; Romelyn Delos Santos; Pavithra Viswanath; Joseph F. Costello; Russell O. Pieper; Sabrina M. Ronen
View articletitled, Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment
Supplementary data
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Convergence and Technologies

Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments
Gregory J. Kimmel; Mark Dane; Laura M. Heiser; Philipp M. Altrock; Noemi Andor
View articletitled, Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments
Supplementary data
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Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period
David M. McClatchy; Henning Willers; Aaron N. Hata; Zofia Piotrowska; Lecia V. Sequist; Harald Paganetti; Clemens Grassberger
View articletitled, Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period
Supplementary data
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Population and Prevention Science

Postdiagnostic Fruit and Vegetable Consumption and Breast Cancer Survival: Prospective Analyses in the Nurses' Health Studies
Maryam S. Farvid; Michelle D. Holmes; Wendy Y. Chen; Bernard A. Rosner; Rulla M. Tamimi; Walter C. Willett; A. Heather Eliassen
View articletitled, Postdiagnostic Fruit and Vegetable Consumption and Breast Cancer Survival: Prospective Analyses in the Nurses' Health Studies
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