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1 November 2020
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Acquired resistance to EGFR tyrosine kinase inhibitors such as osimertinib involves both EGFR resistance mutations and EGFR-independent mechanisms (e.g., activation of alternate receptor tyrosine kinases). Sun and colleagues reported the discovery of IACS-13909, an allosteric inhibitor of SHP2 that is able to overcome both types of resistance mechanisms in preclinical models. Targeting SHP2 may present a promising strategy to tackle the plasticity and heterogeneity of tyrosine kinase inhibitor resistance. For details, see article by Sun and colleagues on page 4840.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Reviews
Cancer Research Highlights
Priority Report
Genome and Epigenome
EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6
Shilpa Patil; Benjamin Steuber; Waltraut Kopp; Vijayalakshmi Kari; Laura Urbach; Xin Wang; Stefan Küffer; Hanibal Bohnenberger; Dimitra Spyropoulou; Zhe Zhang; Lennart Versemann; Mark Sebastian Bösherz; Marius Brunner; Jochen Gaedcke; Philipp Ströbel; Jin-San Zhang; Albrecht Neesse; Volker Ellenrieder; Shiv K. Singh; Steven A. Johnsen; Elisabeth Hessmann
KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis
Guoliang Li; Thanigaivelan Kanagasabai; Wenfu Lu; Mike R. Zou; Shang-Min Zhang; Sherly I. Celada; Michael G. Izban; Qi Liu; Tao Lu; Billy R. Ballard; Xinchun Zhou; Samuel E. Adunyah; Robert J. Matusik; Qin Yan; Zhenbang Chen
Molecular Cell Biology
Author Choice
ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer
Jelena Urosevic; María Teresa Blasco; Alicia Llorente; Anna Bellmunt; Antoni Berenguer-Llergo; Marc Guiu; Adrià Cañellas; Esther Fernandez; Ivan Burkov; Maria Clapés; Mireia Cartanà; Cristina Figueras-Puig; Eduard Batlle; Angel R. Nebreda; Roger R. Gomis
FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy
Nicola Manfrini; Marilena Mancino; Annarita Miluzio; Stefania Oliveto; Matteo Balestra; Piera Calamita; Roberta Alfieri; Riccardo L. Rossi; Marco Sassoè-Pognetto; Chiara Salio; Alessandro Cuomo; Tiziana Bonaldi; Marcello Manfredi; Emilio Marengo; Elia Ranzato; Simona Martinotti; Davide Cittaro; Giovanni Tonon; Stefano Biffo
Tumor Biology and Immunology
Author Choice
Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Brian Koss; Bradley D. Shields; Erin M. Taylor; Aaron J. Storey; Stephanie D. Byrum; Allen J. Gies; Charity L. Washam; Samrat Roy Choudhury; Jeong Hyun Ahn; Hidetaka Uryu; Jason B. Williams; Kimberly J. Krager; Tung-Chin Chiang; Samuel G. Mackintosh; Rick D. Edmondson; Nukhet Aykin-Burns; Thomas F. Gajewski; Gang Greg Wang; Alan J. Tackett
PET Reporter Gene Imaging and Ganciclovir-Mediated Ablation of Chimeric Antigen Receptor T Cells in Solid Tumors
Surya Murty; Louai Labanieh; Tara Murty; Gayatri Gowrishankar; Tom Haywood; Israt S. Alam; Corinne Beinat; Elise Robinson; Amin Aalipour; Dorota D. Klysz; Jennifer R. Cochran; Robbie G. Majzner; Crystal L. Mackall; Sanjiv S. Gambhir
A DNA Hypomethylating Drug Alters the Tumor Microenvironment and Improves the Effectiveness of Immune Checkpoint Inhibitors in a Mouse Model of Pancreatic Cancer
Tamas A. Gonda; Jarwei Fang; Martha Salas; Catherine Do; Emily Hsu; Anna Zhukovskaya; Ariel Siegel; Ryota Takahashi; Zoila A. Lopez-Bujanda; Charles G. Drake; Gulam A. Manji; Timothy C. Wang; Kenneth P. Olive; Benjamin Tycko
Author Choice
Visualization of Activated T Cells by OX40-ImmunoPET as a Strategy for Diagnosis of Acute Graft-versus-Host Disease
Israt S. Alam; Federico Simonetta; Lukas Scheller; Aaron T. Mayer; Surya Murty; Ophir Vermesh; Tomomi W. Nobashi; Juliane K. Lohmeyer; Toshihito Hirai; Jeanette Baker; Kenneth H. Lau; Robert Negrin; Sanjiv S. Gambhir
Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer
Piotr Przanowski; Song Lou; Rachisan Djiake Tihagam; Tanmoy Mondal; Caroline Conlan; Gururaj Shivange; Ilyas Saltani; Chandrajeet Singh; Kun Xing; Benjamin B. Morris; Marty W. Mayo; Luis Teixeira; Jacqueline Lehmann-Che; Jogender Tushir-Singh; Sanchita Bhatnagar
Translational Science
5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA-Mutant Colorectal Cancers
Yiqing Zhao; Xiujing Feng; Yicheng Chen; J. Eva Selfridge; Shashank Gorityala; Zhanwen Du; Janet M. Wang; Yujun Hao; Gino Cioffi; Ronald A. Conlon; Jill S. Barnholtz-Sloan; Joel Saltzman; Smitha S. Krishnamurthi; Shaveta Vinayak; Martina Veigl; Yan Xu; David L. Bajor; Sanford D. Markowitz; Neal J. Meropol; Jennifer R. Eads; Zhenghe Wang
Author Choice
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Yuting Sun; Brooke A. Meyers; Barbara Czako; Paul Leonard; Faika Mseeh; Angela L. Harris; Qi Wu; Sarah Johnson; Connor A. Parker; Jason B. Cross; Maria Emilia Di Francesco; Benjamin J. Bivona; Christopher A. Bristow; Jason P. Burke; Caroline C. Carrillo; Christopher L. Carroll; Qing Chang; Ningping Feng; Guang Gao; Sonal Gera; Virginia Giuliani; Justin K. Huang; Yongying Jiang; Zhijun Kang; Jeffrey J. Kovacs; Chiu-Yi Liu; Anastasia M. Lopez; Xiaoyan Ma; Pijus K. Mandal; Timothy McAfoos; Meredith A. Miller; Robert A. Mullinax; Michael Peoples; Vandhana Ramamoorthy; Sahil Seth; Nakia D. Spencer; Erika Suzuki; Christopher C. Williams; Simon S. Yu; Andy M. Zuniga; Giulio F. Draetta; Joseph R. Marszalek; Timothy P. Heffernan; Nancy E. Kohl; Philip Jones
Convergence and Technologies
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