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Macrophages play complex roles in cancer, including both the antitumoral and protumoral roles of M1 and M2 tumor-associated macrophages (TAM), respectively. However, density and topology of distinct TAM phenotypes at tumor center (TC) versus invasive margin (IM) are largely unknown in lung cancer. Based on multiplex staining of a panel of five selected markers (CD68, IL12, CCR7, CD163, and ALOX15) on tissue microarrays from 104 lung cancer specimens, M2 over M1 predominance was observed, in particular at IM. Moreover, spatial distribution analysis demonstrated that tumor cells were closer to M2 TAMs than to M1 TAMs at IM. Lower density of M1 TC-TAMs and higher proximity of tumor cells to M2 IM-TAMs or lower proximity to M1 IM-TAMs were linked with poor survival. For details, see article by Zheng and colleagues on page 4414. - PDF Icon PDF LinkTable of Contents
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Cancer Research
Table of Contents
Breaking Insights
Obituary
Reviews
Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Genome and Epigenome
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas
Multiomic Analysis of Subtype Evolution and Heterogeneity in High-Grade Serous Ovarian Carcinoma
STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer
Molecular Cell Biology
Tumor Biology and Immunology
Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non–Small Cell Lung Carcinoma
The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma
Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer
Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non–Muscle-Invasive Bladder Cancer
Translational Science
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers
Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death
Convergence and Technologies
An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells
Population and Prevention Science
Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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