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Volume 80, Issue 18
15 September 2020
Cancer Research Cover Image for Volume 80, Issue 18
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    Cover Image

    issue cover
    SMARCA4/BRG1 mutations account for 10%-15% of lung cancers. DNA fibers provide a microscopic foray into the realm of ongoing DNA replication events, demonstrating that loss of BRG1 promotes tumor progression not through over proliferation but via changes at replication forks due to increased firing of replication origins, contributing to fork stress and genome instability in lung cancers. For details, see article by Gupta and colleagues on page 3841.
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Insights

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Obituary

Zena Werb, Ph.D, “Queen of the Matrix”: In Memoriam (1945–2020)
Shahin Rafii; David Lyden
View articletitled, Zena Werb, Ph.D, “Queen of the Matrix”: In Memoriam (1945–2020)
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Reviews

Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes
Daniela Matei; Kenneth P. Nephew
View articletitled, Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes
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Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine
Aaron H. Morris; Sophia M. Orbach; Grace G. Bushnell; Robert S. Oakes; Jacqueline S. Jeruss; Lonnie D. Shea
View articletitled, Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine
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Cancer Research Highlights

Speed Kills: Advancement in Th17 Cell Adoptive Cell Therapy for Solid Tumors
Steven N. Fiering; Gregory W. Ho
View articletitled, Speed Kills: Advancement in Th17 Cell Adoptive Cell Therapy for Solid Tumors
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Catch and Release: Mutant YAP as a Molecular Driver of Tumor Cell Dissemination
Shawn M. Davidson
View articletitled, Catch and Release: Mutant YAP as a Molecular Driver of Tumor Cell Dissemination
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Controversy and Consensus

The Myc and Ras Partnership in Cancer: Indistinguishable Alliance or Contextual Relationship?
Wadie D. Mahauad-Fernandez; Dean W. Felsher
View articletitled, The Myc and Ras Partnership in Cancer: Indistinguishable Alliance or Contextual Relationship?
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Genome and Epigenome

Author Choice
The D2 and D3 Sublineages of Human Papilloma Virus 16–Positive Cervical Cancer in Guatemala Differ in Integration Rate and Age of Diagnosis
Hong Lou; Joseph F. Boland; Edmundo Torres-Gonzalez; Anaseidy Albanez; Weiyin Zhou; Mia K. Steinberg; Lena Diaw; Jason Mitchell; David Roberson; Michael Cullen; Lisa Garland; Sara Bass; Robert D. Burk; Meredith Yeager; Nicolas Wentzensen; Mark Schiffman; Enrique Alvirez Freites; Eduardo Gharzouzi; Lisa Mirabello; Michael Dean
View articletitled, The D2 and D3 Sublineages of Human Papilloma Virus 16–Positive Cervical Cancer in Guatemala Differ in Integration Rate and Age of Diagnosis
Supplementary data
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Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Yutaka Midorikawa; Shogo Yamamoto; Kenji Tatsuno; Claire Renard-Guillet; Shingo Tsuji; Akimasa Hayashi; Hiroki Ueda; Shiro Fukuda; Takanori Fujita; Hiroto Katoh; Shumpei Ishikawa; Kyle R. Covington; Chad J. Creighton; Masahiko Sugitani; David A. Wheeler; Tatsuhiro Shibata; Genta Nagae; Tadatoshi Takayama; Hiroyuki Aburatani
View articletitled, Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Supplementary data
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Metabolism and Chemical Biology

Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis
Jonathan M. Ghergurovich; Mark Esposito; Zihong Chen; Joshua Z. Wang; Vrushank Bhatt; Taijin Lan; Eileen White; Yibin Kang; Jessie Yanxiang Guo; Joshua D. Rabinowitz
View articletitled, Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis
Supplementary data
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Author Choice
Decreased Mitochondrial DNA Content Drives OXPHOS Dysregulation in Chromophobe Renal Cell Carcinoma
Yi Xiao; Rosanna Clima; Jonas Busch; Anja Rabien; Ergin Kilic; Sonia L. Villegas; Bernd Timmermann; Marcella Attimonelli; Klaus Jung; David Meierhofer
View articletitled, Decreased Mitochondrial DNA Content Drives OXPHOS Dysregulation in Chromophobe Renal Cell Carcinoma
Supplementary data
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Molecular Cell Biology

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency
Manav Gupta; Carla P. Concepcion; Caroline G. Fahey; Hasmik Keshishian; Arjun Bhutkar; Christine F. Brainson; Francisco J. Sanchez-Rivera; Patrizia Pessina; Jonathan Y. Kim; Antoine Simoneau; Margherita Paschini; Mary C. Beytagh; Caroline R. Stanclift; Monica Schenone; D.R. Mani; Chendi Li; Audris Oh; Fei Li; Hai Hu; Angeliki Karatza; Roderick T. Bronson; Alice T. Shaw; Aaron N. Hata; Kwok-Kin Wong; Lee Zou; Steven A. Carr; Tyler Jacks; Carla F. Kim
View articletitled, BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency
Supplementary data
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RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal
Allison E. Bridges; Sabarish Ramachandran; Rajneesh Pathania; Utkarsh Parwal; Adrienne Lester; Pragya Rajpurohit; Daley S. Morera; Nikhil Patel; Nagendra Singh; Hasan Korkaya; Santhakumar Manicassamy; Puttur D. Prasad; Vinata B. Lokeshwar; Bal L. Lokeshwar; Vadivel Ganapathy; Muthusamy Thangaraju
View articletitled, <em>RAD51AP1</em> Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal
Supplementary data
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YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation
David C. Benjamin; Joon Ho Kang; Bashar Hamza; Emily M. King; John M. Lamar; Scott R. Manalis; Richard O. Hynes
View articletitled, YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation
Supplementary data
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CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Yijie Wang; Yan Chen; Lei Bao; Bo Zhang; Jennifer E. Wang; Ashwani Kumar; Chao Xing; Yingfei Wang; Weibo Luo
View articletitled, CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Supplementary data
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Tumor Biology and Immunology

Interaction with CD68 and Regulation of GAS6 Expression by Endosialin in Fibroblasts Drives Recruitment and Polarization of Macrophages in Hepatocellular Carcinoma
Fa Yang; Yan Wei; Donghui Han; Yu Li; Shengjia Shi; Dian Jiao; Jieheng Wu; Qiang Zhang; Changhong Shi; Lijun Yang; Wei Song; Jingliang Zhang; Yueheng Han; Rui Zhang; An-Gang Yang; Dimiter S. Dimitrov; Aizhi Zhao; Weijun Qin; Weihong Wen
View articletitled, Interaction with CD68 and Regulation of GAS6 Expression by Endosialin in Fibroblasts Drives Recruitment and Polarization of Macrophages in Hepatocellular Carcinoma
Supplementary data
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P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors
Andrea Romagnani; Elsa Rottoli; Emilia Maria Cristina Mazza; Tanja Rezzonico-Jost; Benedetta De Ponte Conti; Michele Proietti; Michela Perotti; Elisa Civanelli; Lisa Perruzza; Alberico L. Catapano; Andrea Baragetti; Elena Tenedini; Enrico Tagliafico; Simonetta Falzoni; Francesco Di Virgilio; Giuseppe Danilo Norata; Silvio Bicciato; Fabio Grassi
View articletitled, P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors
Supplementary data
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IL6 Fuels Durable Memory for Th17 Cell–Mediated Responses to Tumors
Hannah M. Knochelmann; Connor J. Dwyer; Aubrey S. Smith; Jacob S. Bowers; Megan M. Wyatt; Michelle H. Nelson; Guillermo O. Rangel Rivera; Joshua D. Horton; Carsten Krieg; Kent Armeson; Gregory B. Lesinski; Mark P. Rubinstein; Zihai Li; Chrystal M. Paulos
View articletitled, IL6 Fuels Durable Memory for Th17 Cell–Mediated Responses to Tumors
Supplementary data
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ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Jill M. Westcott; Sharon Camacho; Apsra Nasir; Molly E. Huysman; Raneen Rahhal; Tuyen T. Dang; Anna T. Riegel; Rolf A. Brekken; Gray W. Pearson
View articletitled, ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Supplementary data
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FTO Inhibition Enhances the Antitumor Effect of Temozolomide by Targeting MYC-miR-155/23a Cluster-MXI1 Feedback Circuit in Glioma
Li Xiao; Xiaodi Li; Zekun Mu; Jianwen Zhou; Peng Zhou; Chen Xie; Songshan Jiang
View articletitled, FTO Inhibition Enhances the Antitumor Effect of Temozolomide by Targeting MYC-miR-155/23a Cluster-MXI1 Feedback Circuit in Glioma
Supplementary data
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Plasma Gelsolin Inhibits CD8+ T-cell Function and Regulates Glutathione Production to Confer Chemoresistance in Ovarian Cancer
Meshach Asare-Werehene; Laudine Communal; Euridice Carmona; Youngjin Han; Yong Sang Song; Dylan Burger; Anne-Marie Mes-Masson; Benjamin K. Tsang
View articletitled, Plasma Gelsolin Inhibits CD8<sup>+</sup> T-cell Function and Regulates Glutathione Production to Confer Chemoresistance in Ovarian Cancer
Supplementary data
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A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability
Guido Leoni; Anna Morena D'Alise; Gabriella Cotugno; Francesca Langone; Irene Garzia; Maria De Lucia; Imma Fichera; Rosa Vitale; Veronica Bignone; Fabio Giovanni Tucci; Federica Mori; Adriano Leuzzi; Elena Di Matteo; Fulvia Troise; Adele Abbate; Rossella Merone; Valentino Ruzza; Maria Grazia Diodoro; Mahesh Yadav; Monica Gordon-Alonso; Cristophe Vanhaver; Maddalena Panigada; Elisa Soprana; Antonio Siccardi; Antonella Folgori; Stefano Colloca; Pierre van der Bruggen; Alfredo Nicosia; Armin Lahm; Maria Teresa Catanese; Elisa Scarselli
View articletitled, A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability
Supplementary data
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Convergence and Technologies

Mathematical Modeling Provides Evidence for Niche Competition in Human AML and Serves as a Tool to Improve Risk Stratification
Thomas Stiehl; Wenwen Wang; Christoph Lutz; Anna Marciniak-Czochra
View articletitled, Mathematical Modeling Provides Evidence for Niche Competition in Human AML and Serves as a Tool to Improve Risk Stratification
Supplementary data
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Author Choice
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Tiril Hillestad; Tord Hompland; Christina S. Fjeldbo; Vilde E. Skingen; Unn Beate Salberg; Eva-Katrine Aarnes; Anja Nilsen; Kjersti V. Lund; Tina S. Evensen; Gunnar B. Kristensen; Trond Stokke; Heidi Lyng
View articletitled, MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer
Supplementary data
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Population and Prevention Science

Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk
Fangcheng Yuan; Rayjean J. Hung; Naomi Walsh; Han Zhang; Elizabeth A. Platz; William Wheeler; Lei Song; Alan A. Arslan; Laura E. Beane Freeman; Paige Bracci; Federico Canzian; Mengmeng Du; Steven Gallinger; Graham G. Giles; Phyllis J. Goodman; Charles Kooperberg; Loic Le Marchand; Rachel E. Neale; Jonas Rosendahl; Ghislaine Scelo; Xiao-Ou Shu; Kala Visvanathan; Emily White; Wei Zheng; Demetrius Albanes; Pilar Amiano; Gabriella Andreotti; Ana Babic; William R. Bamlet; Sonja I. Berndt; Paul Brennan; Bas Bueno-de-Mesquita; Julie E. Buring; Peter T. Campbell; Stephen J. Chanock; Charles S. Fuchs; J. Michael Gaziano; Michael G. Goggins; Thilo Hackert; Patricia Hartge; Manal M. Hassan; Elizabeth A. Holly; Robert N. Hoover; Verena Katzke; Holger Kirsten; Robert C. Kurtz; I-Min Lee; Nuria Malats; Roger L. Milne; Neil Murphy; Kimmie Ng; Ann L. Oberg; Miquel Porta; Kari G. Rabe; Francisco X. Real; Nathaniel Rothman; Howard D. Sesso; Debra T. Silverman; Ian M. Thompson; Jean Wactawski-Wende; Xiaoliang Wang; Nicolas Wentzensen; Lynne R. Wilkens; Herbert Yu; Anne Zeleniuch-Jacquotte; Jianxin Shi; Eric J. Duell; Laufey T. Amundadottir; Donghui Li; Gloria M. Petersen; Brian M. Wolpin; Harvey A. Risch; Kai Yu; Alison P. Klein; Rachael Stolzenberg-Solomon
View articletitled, Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk
Supplementary data
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Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank
Anika Knuppel; Georgina K. Fensom; Eleanor L. Watts; Marc J. Gunter; Neil Murphy; Keren Papier; Aurora Perez-Cornago; Julie A. Schmidt; Karl Smith Byrne; Ruth C. Travis; Timothy J. Key
View articletitled, Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank
Supplementary data
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Correction

Correction: KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis
Peng Yuan; Xiao-Hong He; Ye-Fei Rong; Jing Cao; Yong Li; Yun-ping Hu; Yingbin Liu; Dangsheng Li; Wenhui Lou; Mo-Fang Liu
View articletitled, Correction: KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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