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15 July 2020
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Chemotherapy causes inflammatory changes, such as IL8 upregulation in tumors, inducing a drug transporter, ABCB1, expression in tumor endothelial cells. This causes drug resistance in tumor blood vessels. It is possible that tumor endothelial cells can survive during chemotherapy and keep providing a gateway for cancer metastasis. Targeting ABCB1 in tumor endothelial cells, or IL8 inhibition, represents a novel strategy to overcome cancer drug resistance. For details, see article by Kikuchi and colleagues on page 2996. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Controversy and Consensus
Molecular Cell Biology
The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype
Niels Vandamme; Geertrui Denecker; Kenneth Bruneel; Gillian Blancke; Özden Akay; Joachim Taminau; Jordy De Coninck; Eva De Smedt; Nicolas Skrypek; Wouter Van Loocke; Jasper Wouters; David Nittner; Corinna Köhler; Douglas S. Darling; Phil F. Cheng; Marieke I.G. Raaijmakers; Mitchell P. Levesque; Udupi Girish Mallya; Mairin Rafferty; Balazs Balint; William M. Gallagher; Lieve Brochez; Danny Huylebroeck; Jody J. Haigh; Vanessa Andries; Florian Rambow; Pieter Van Vlierberghe; Steven Goossens; Joost J. van den Oord; Jean-Christophe Marine; Geert Berx
Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome
Hiroshi Kikuchi; Nako Maishi; Dorcas A. Annan; Mohammad Towfik Alam; Randa Ibrahim Hassan Dawood; Masumi Sato; Masahiro Morimoto; Ryo Takeda; Keita Ishizuka; Ryuji Matsumoto; Tomoshige Akino; Kunihiko Tsuchiya; Takashige Abe; Takahiro Osawa; Naoto Miyajima; Satoru Maruyama; Toru Harabayashi; Manabu Azuma; Katsushige Yamashiro; Kaname Ameda; Akira Kashiwagi; Yoshihiro Matsuno; Yasuhiro Hida; Nobuo Shinohara; Kyoko Hida
Tumor Biology and Immunology
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases
Melanie Kogler; Luigi Tortola; Gian Luca Negri; Alexandra Leopoldi; Amal M. El-Naggar; Stefan Mereiter; Carlos Gomez-Diaz; Roberto Nitsch; Davide Tortora; Anoop M. Kavirayani; Bianca V. Gapp; Shuan Rao; Iris Uribesalgo; David Hoffmann; Domagoj Cikes; Maria Novatchkova; David A. Williams; Jeffrey M. Trent; Fumiyo Ikeda; Mads Daugaard; Astrid Hagelkruys; Poul H. Sorensen; Josef M. Penninger
Translational Science
Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition
Man-Li Luo; Fang Zheng; Wenying Chen; Zhi-Mei Liang; Gurushankar Chandramouly; Jianan Tan; Nicholas A. Willis; Chun-Hau Chen; Mateus de Oliveira Taveira; Xiao Zhen Zhou; Kun Ping Lu; Ralph Scully; Gerburg M. Wulf; Hai Hu
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