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Pathology images of tumor tissues provide detailed information on the different types of cells that constitute the tumor microenvironment. Artificial intelligence can automatically and accurately identify and stain the nuclei of tumor cells, stromal cells, lymphocytes, macrophages, blood cells, and karyorrhexis from pathology images of lung adenocarcinoma. The computational power aids in clinical diagnosis and enables the quantification of tumor microenvironment-related features that correlate with patient survival and the gene expression of biological pathways. For details, see article by Wang and colleagues on page 2056. - PDF Icon PDF LinkTable of Contents
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Cancer Research
Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Molecular Cell Biology
Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer
Tumor Biology and Immunology
A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy
Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis
Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma
Translational Science
Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations
Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma
A Protease-Activated Fluorescent Probe Allows Rapid Visualization of Keratinocyte Carcinoma during Excision
Resource Reports
Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer
Correction
Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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