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15 May 2020
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Cover Image
Cover Image
Pathology images of tumor tissues provide detailed information on the different types of cells that constitute the tumor microenvironment. Artificial intelligence can automatically and accurately identify and stain the nuclei of tumor cells, stromal cells, lymphocytes, macrophages, blood cells, and karyorrhexis from pathology images of lung adenocarcinoma. The computational power aids in clinical diagnosis and enables the quantification of tumor microenvironment-related features that correlate with patient survival and the gene expression of biological pathways. For details, see article by Wang and colleagues on page 2056. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Molecular Cell Biology
Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer
Koen D. Flach; Manikandan Periyasamy; Ajit Jadhav; Dorjbal Dorjsuren; Joseph C. Siefert; Theresa E. Hickey; Mark Opdam; Hetal Patel; Sander Canisius; David M. Wilson, III; Maria Donaldson Collier; Stefan Prekovic; Marja Nieuwland; Roelof J.C. Kluin; Alexey V. Zakharov; Jelle Wesseling; Lodewyk F.A. Wessels; Sabine C. Linn; Wayne D. Tilley; Anton Simeonov; Simak Ali; Wilbert Zwart
Tumor Biology and Immunology
Author Choice
A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Christophe A. Girard; Margaux Lecacheur; Rania Ben Jouira; Ilona Berestjuk; Serena Diazzi; Virginie Prod'homme; Aude Mallavialle; Frédéric Larbret; Maéva Gesson; Sébastien Schaub; Sabrina Pisano; Stéphane Audebert; Bernard Mari; Cédric Gaggioli; Eleonora Leucci; Jean-Christophe Marine; Marcel Deckert; Sophie Tartare-Deckert
Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy
Nadine Santana-Magal; Leen Farhat-Younis; Amit Gutwillig; Annette Gleiberman; Diana Rasoulouniriana; Lior Tal; Dvir Netanely; Ron Shamir; Rachel Blau; Meora Feinmesser; Oran Zlotnik; Haim Gutman; Ian L. Linde; Nathan E. Reticker-Flynn; Peleg Rider; Yaron Carmi
Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis
Pierre-Antoine Bissey; Pauline Mathot; Catherine Guix; Mélissa Jasmin; Isabelle Goddard; Clélia Costechareyre; Nicolas Gadot; Jean-Guy Delcros; Sachitanand M. Mali; Rudi Fasan; André-Patrick Arrigo; Robert Dante; Gabriel Ichim; Patrick Mehlen; Joanna Fombonne
Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma
Min-Wei Yang; Ling-Ye Tao; Yong-Sheng Jiang; Jian-Yu Yang; Yan-Miao Huo; De-Jun Liu; Jiao Li; Xue-Liang Fu; Ruizhe He; Chaoyi Lin; Wei Liu; Jun-Feng Zhang; Rong Hua; Qing Li; Shu-Heng Jiang; Li-Peng Hu; Guang-Ang Tian; Xiao-Xin Zhang; Ningning Niu; Ping Lu; Juanjuan Shi; Gary G. Xiao; Li-Wei Wang; Jing Xue; Zhi-Gang Zhang; Yong-Wei Sun
Translational Science
Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations
Jacqueline H. Starrett; Alexis A. Guernet; Maria Emanuela Cuomo; Kamrine E. Poels; Iris K. van Alderwerelt van Rosenburgh; Amy Nagelberg; Dylan Farnsworth; Kristin S. Price; Hina Khan; Kumar Dilip Ashtekar; Mmaserame Gaefele; Deborah Ayeni; Tyler F. Stewart; Alexandra Kuhlmann; Susan M. Kaech; Arun M. Unni; Robert Homer; William W. Lockwood; Franziska Michor; Sarah B. Goldberg; Mark A. Lemmon; Paul D. Smith; Darren A.E. Cross; Katerina Politi
Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma
Yi Hu; Huimin Liu; Chuanfeng Fang; Chen Li; Fjorela Xhyliu; Hayley Dysert; Juraj Bodo; Gabriel Habermehl; Benjamin E. Russell; Wenjun Li; Marcia Chappell; Xiaofeng Jiang; Sarah L. Ondrejka; Eric D. Hsi; Jaroslaw P. Maciejewski; Qing Yi; Kenneth C. Anderson; Nikhil C. Munshi; Geyou Ao; Jason N. Valent; Jianhong Lin; Jianjun Zhao
A Protease-Activated Fluorescent Probe Allows Rapid Visualization of Keratinocyte Carcinoma during Excision
Ethan Walker; Yiqiao Liu; InYoung Kim; Mark Biro; Sukanya Raj Iyer; Harib Ezaldein; Jeffrey Scott; Miesha Merati; Rachel Mistur; Bo Zhou; Brian Straight; Joshua J. Yim; Matthew Bogyo; Margaret Mann; David L. Wilson; James P. Basilion; Daniel L. Popkin
Resource Reports
Computational Staining of Pathology Images to Study the Tumor Microenvironment in Lung Cancer
Shidan Wang; Ruichen Rong; Donghan M. Yang; Junya Fujimoto; Shirley Yan; Ling Cai; Lin Yang; Danni Luo; Carmen Behrens; Edwin R. Parra; Bo Yao; Lin Xu; Tao Wang; Xiaowei Zhan; Ignacio I. Wistuba; John Minna; Yang Xie; Guanghua Xiao
Correction
Correction: Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer
Shangze Li; Ka-wing Fong; Galina Gritsina; Ali Zhang; Jonathan C. Zhao; Jung Kim; Adam Sharp; Wei Yuan; Caterina Aversa; Ximing J. Yang; Peter S. Nelson; Felix Y. Feng; Arul M. Chinnaiyan; Johann S. de Bono; Colm Morrissey; Matthew B. Rettig; Jindan Yu
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