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1 May 2019
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Pediatric glioblastoma harbors an unexpected degree of intratumoral genetic heterogeneity. The coexistence of genetic subclones is here represented as branches of a tree with cells/leaves of different colors. Some of these subclones are more ancestral than others, as represented by their earlier branching points. Subclonal compartments are fueled by slow-cycling cancer stem cells, which are represented as the roots of the tree. Four cancer stem cells (pink, orange, blue, and yellow) each generated branches (or subclones) of the same color. However, one cancer stem cell (black) is mostly dormant and will produce its progeny at relapse. The cancer stem cell architecture of pediatric glioblastoma may explain why the genetic makeup of diagnostic and relapse samples are widely different. For details, see article by Hoffman and colleagues on page 2111. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Obituary
Review
Cancer Research Highlights
Controversy and Consensus
Genome and Epigenome
Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma
Mary Hoffman; Aaron H. Gillmor; Daniel J. Kunz; Michael J. Johnston; Ana Nikolic; Kiran Narta; Mehdi Zarrei; Jennifer King; Katrina Ellestad; Ngoc Ha Dang; Florence M.G. Cavalli; Michelle M. Kushida; Fiona J. Coutinho; Yuankun Zhu; Betty Luu; Yussanne Ma; Andrew J. Mungall; Richard Moore; Marco A. Marra; Michael D. Taylor; Trevor J. Pugh; Peter B. Dirks; Douglas Strother; Lucie Lafay-Cousin; Adam C. Resnick; Stephen Scherer; Donna L. Senger; Benjamin D. Simons; Jennifer A. Chan; A. Sorana Morrissy; Marco Gallo
Metabolism and Chemical Biology
Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish
Fiona Henderson; Hannah R. Johnston; Andrew P. Badrock; Emrys A. Jones; Duncan Forster; Raghavendar T. Nagaraju; Christos Evangelou; Jivko Kamarashev; Michael Green; Michael Fairclough; Irene Barinaga-Rementeria Ramirez; Shuning He; B. Ewa Snaar-Jagalska; Katherine Hollywood; Warwick B. Dunn; Herman P. Spaink; Michael P. Smith; Paul Lorigan; Emmanuelle Claude; Kaye J. Williams; Adam W. McMahon; Adam Hurlstone
Molecular Cell Biology
Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription
Bryson W. Katona; Rebecca A. Glynn; Kayla E. Paulosky; Zijie Feng; Caroline I. Davis; Jian Ma; Corbett T. Berry; Katherine M. Szigety; Smita Matkar; Yuanyuan Liu; Haoren Wang; Yuan Wu; Xin He; Bruce D. Freedman; Donita C. Brady; Xianxin Hua
Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Jun Wang; Diana M. Merino; Nicholas Light; Brian L. Murphy; Yong-Dong Wang; Xiaohui Guo; Andrew P. Hodges; Lianne Q. Chau; Kun-Wei Liu; Girish Dhall; Shahab Asgharzadeh; Erin N. Kiehna; Ryan J. Shirey; Kim D. Janda; Michael D. Taylor; David Malkin; David W. Ellison; Scott R. VandenBerg; Charles G. Eberhart; Rosalie C. Sears; Martine F. Roussel; Richard J. Gilbertson; Robert J. Wechsler-Reya
Author Choice
EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway
Aling Shen; Youqin Chen; Liya Liu; Yue Huang; Hongwei Chen; Fei Qi; Jiumao Lin; Zhiqing Shen; Xiangyan Wu; Meizhu Wu; Qiongyu Li; Liman Qiu; Na Yu; Thomas J. Sferra; Jun Peng
Tumor Biology and Immunology
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis
Suchitra Natarajan; Kaitlyn M. Foreman; Michaela I. Soriano; Ninna S. Rossen; Hussein Shehade; Daniel R. Fregoso; Joshua T. Eggold; Venkatesh Krishnan; Oliver Dorigo; Adam J. Krieg; Sarah C. Heilshorn; Subarna Sinha; Katherine C. Fuh; Erinn B. Rankin
Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma
Giorgia Mastrella; Mengzhuo Hou; Min Li; Veit M. Stoecklein; Nina Zdouc; Marie N.M. Volmar; Hrvoje Miletic; Sören Reinhard; Christel C. Herold-Mende; Susanne Kleber; Katharina Eisenhut; Gaetano Gargiulo; Michael Synowitz; Angelo L. Vescovi; Patrick N. Harter; Josef M. Penninger; Ernst Wagner; Michel Mittelbronn; Rolf Bjerkvig; Dolores Hambardzumyan; Ulrich Schüller; Jörg-Christian Tonn; Josefine Radke; Rainer Glass; Roland E. Kälin
Inhibition of miR-328–3p Impairs Cancer Stem Cell Function and Prevents Metastasis in Ovarian Cancer
Amit K. Srivastava; Ananya Banerjee; Tiantian Cui; Chunhua Han; Shurui Cai; Lu Liu; Dayong Wu; Ri Cui; Zaibo Li; Xiaoli Zhang; Guozhen Xie; Karuppaiyah Selvendiran; Srinivas Patnaik; Adam R. Karpf; Jinsong Liu; David E. Cohn; Qi-En Wang
Translational Science
Author Choice
Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer
Tara N. Fujimoto; Lauren E. Colbert; Yanqing Huang; Jessica M. Molkentine; Amit Deorukhkar; Laura Baseler; Marimar de la Cruz Bonilla; Meifang Yu; Daniel Lin; Sonal Gupta; Peter K. Cabeceiras; Charles V. Kingsley; Ramesh C. Tailor; Gabriel O. Sawakuchi; Eugene J. Koay; Helen Piwnica-Worms; Anirban Maitra; Cullen M. Taniguchi
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia
Ernesto Diaz-Flores; Evan Q. Comeaux; Kailyn L. Kim; Ella Melnik; Kyle Beckman; Kara L. Davis; Kevin Wu; Jon Akutagawa; Olga Bridges; Roberta Marino; Margo Wohlfeil; Benjamin S. Braun; Charles G. Mullighan; Mignon L. Loh
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer
Jörn Weisner; Ina Landel; Christoph Reintjes; Niklas Uhlenbrock; Marija Trajkovic-Arsic; Niklas Dienstbier; Julia Hardick; Swetlana Ladigan; Marius Lindemann; Steven Smith; Lena Quambusch; Rebekka Scheinpflug; Laura Depta; Rajesh Gontla; Anke Unger; Heiko Müller; Matthias Baumann; Carsten Schultz-Fademrecht; Georgia Günther; Abdelouahid Maghnouj; Matthias P. Müller; Michael Pohl; Christian Teschendorf; Heiner Wolters; Richard Viebahn; Andrea Tannapfel; Waldemar Uhl; Jan G. Hengstler; Stephan A. Hahn; Jens T. Siveke; Daniel Rauh
Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma
Atsushi Takai; Hien Dang; Naoki Oishi; Subreen Khatib; Sean P. Martin; Dana A. Dominguez; Ji Luo; Rachel Bagni; Xiaolin Wu; Katie Powell; Qing-Hai Ye; Hu-Liang Jia; Lun-Xiu Qin; Jinqiu Chen; Gary A. Mitchell; Xiaoling Luo; Snorri S. Thorgeirsson; Xin Wei Wang
MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
Thomas P. Howard; Taylor E. Arnoff; Melinda R. Song; Andrew O. Giacomelli; Xiaofeng Wang; Andrew L. Hong; Neekesh V. Dharia; Su Wang; Francisca Vazquez; Minh-Tam Pham; Ann M. Morgan; Franziska Wachter; Gregory H. Bird; Guillaume Kugener; Elaine M. Oberlick; Matthew G. Rees; Hong L. Tiv; Justin H. Hwang; Katherine H. Walsh; April Cook; John M. Krill-Burger; Aviad Tsherniak; Prafulla C. Gokhale; Peter J. Park; Kimberly Stegmaier; Loren D. Walensky; William C. Hahn; Charles W.M. Roberts
Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales
Michael Woolman; Claudia M. Kuzan-Fischer; Isabelle Ferry; Taira Kiyota; Betty Luu; Megan Wu; David G. Munoz; Sunit Das; Ahmed Aman; Michael D. Taylor; James T. Rutka; Howard J. Ginsberg; Arash Zarrine-Afsar
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