The image shows the activated actin cytoskeleton (red) and accumulation of mRNA processing bodies (green) present in 4T1 metastatic breast cancer cells that have been genetically deleted for the autophagy protein, ATG7. This image is part of the study from Shinde and colleagues, which describes the relocalization of spleen tyrosine kinase (SYK) into these processing bodies (P-bodies) during the induction of epithelial-mesenchymal transition. Similar to genetic inhibition of autophagy, pharmacologic inhibition of SYK activity prevents P-body clearance, inhibiting the later steps of metastatic outgrowth. For details, see article by Shinde and colleagues on page 1831.