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15 March 2019
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MicroRNAs, detected in mitochondria, have been termed mitomiRs. Among them, mitomiR-2392 was shown to be enriched in tongue squamous cell carcinoma cells and to regulate their chemoresistance by reprogramming cell metabolism. Mechanistically, mitomiR-2392 recognizes and binds target sequences in the H-strand of mtDNA with AGO2 and partially inhibits mtDNA transcription. MitomiR-2392 may be a useful biomarker for clinical risk evaluation and an attractive target to overcome chemoresistance. For details, see article by Fan and colleagues on page 1069.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Controversy and Consensus
Priority Report
Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions
Emiliano Cocco; Jamal Benhamida; Sumit Middha; Ahmet Zehir; Kerry Mullaney; Jinru Shia; Rona Yaeger; Liying Zhang; Donna Wong; Liliana Villafania; Khedoudja Nafa; Maurizio Scaltriti; Alexander Drilon; Leonard Saltz; Alison M. Schram; Zsofia K. Stadler; David M. Hyman; Ryma Benayed; Marc Ladanyi; Jaclyn F. Hechtman
Genome and Epigenome
Metabolism and Chemical Biology
Author Choice
Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
Song Fan; Tian Tian; Weixiong Chen; Xiaobin Lv; Xinyuan Lei; Hanqing Zhang; Sheng Sun; Lei Cai; Guokai Pan; Lile He; Zhanpeng Ou; Xinyu Lin; Xinhui Wang; Matthew Francis Perez; Zhiming Tu; Soldano Ferrone; Bakhos A. Tannous; Jinsong Li
Molecular Cell Biology
IFNγ-Induced IFIT5 Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer via miRNA Processing
U-Ging Lo; Rey-Chen Pong; Diane Yang; Leah Gandee; Elizabeth Hernandez; Andrew Dang; Chung-Jung Lin; John Santoyo; Shihong Ma; Rajni Sonavane; Jun Huang; Shu-Fen Tseng; Loredana Moro; Arnaldo A. Arbini; Payal Kapur; Ganesh V. Raj; Dalin He; Chih-Ho Lai; Ho Lin; Jer-Tsong Hsieh
Tumor Biology and Immunology
Author Choice
Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
Bradley D. Shields; Brian Koss; Erin M. Taylor; Aaron J. Storey; Kirk L. West; Stephanie D. Byrum; Samuel G. Mackintosh; Rick Edmondson; Fade Mahmoud; Sara C. Shalin; Alan J. Tackett
GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon
Mohammad Salem; Caroline Wallace; Maria Velegraki; Anqi Li; Ephraim Ansa-Addo; Alessandra Metelli; Hyunwoo Kwon; Brian Riesenberg; Bill Wu; Yongliang Zhang; Silvia Guglietta; Shaoli Sun; Bei Liu; Zihai Li
Translational Science
Author Choice
Early Noninvasive Detection of Response to Targeted Therapy in Non–Small Cell Lung Cancer
Jillian Phallen; Alessandro Leal; Brian D. Woodward; Patrick M. Forde; Jarushka Naidoo; Kristen A. Marrone; Julie R. Brahmer; Jacob Fiksel; Jamie E. Medina; Stephen Cristiano; Doreen N. Palsgrove; Christopher D. Gocke; Daniel C. Bruhm; Parissa Keshavarzian; Vilmos Adleff; Elizabeth Weihe; Valsamo Anagnostou; Robert B. Scharpf; Victor E. Velculescu; Hatim Husain
Author Choice
Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
Valsamo Anagnostou; Patrick M. Forde; James R. White; Noushin Niknafs; Carolyn Hruban; Jarushka Naidoo; Kristen Marrone; I.K. Ashok Sivakumar; Daniel C. Bruhm; Samuel Rosner; Jillian Phallen; Alessandro Leal; Vilmos Adleff; Kellie N. Smith; Tricia R. Cottrell; Lamia Rhymee; Doreen N. Palsgrove; Christine L. Hann; Benjamin Levy; Josephine Feliciano; Christos Georgiades; Franco Verde; Peter Illei; Qing Kay Li; Edward Gabrielson; Malcolm V. Brock; James M. Isbell; Jennifer L. Sauter; Janis Taube; Robert B. Scharpf; Rachel Karchin; Drew M. Pardoll; Jamie E. Chaft; Matthew D. Hellmann; Julie R. Brahmer; Victor E. Velculescu
Author Choice
A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications
Matthieu Gobin; Petr V. Nazarov; Rolf Warta; Marco Timmer; Guido Reifenberger; Joerg Felsberg; Laurent Vallar; Anthony J. Chalmers; Christel C. Herold-Mende; Roland Goldbrunner; Simone P. Niclou; Eric Van Dyck
Author Choice
Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk
Tao Sun; Rameshwar Patil; Anna Galstyan; Dmytro Klymyshyn; Hui Ding; Alexandra Chesnokova; Webster K. Cavenee; Frank B. Furnari; Vladimir A. Ljubimov; Ekaterina S. Shatalova; Shawn Wagner; Debiao Li; Adam N. Mamelak; Serguei I. Bannykh; Chirag G. Patil; Jeremy D. Rudnick; Jethro Hu; Zachary B. Grodzinski; Arthur Rekechenetskiy; Vida Falahatian; Alexander V. Lyubimov; Yongmei L. Chen; Lai S. Leoh; Tracy R. Daniels-Wells; Manuel L. Penichet; Eggehard Holler; Alexander V. Ljubimov; Keith L. Black; Julia Y. Ljubimova
Population and Prevention Science
Author Choice
Epidemiologic and Clinical Analysis of Cervical Cancer Using Data from the Population-Based Osaka Cancer Registry
Asami Yagi; Yutaka Ueda; Mamoru Kakuda; Yusuke Tanaka; Sayaka Ikeda; Shinya Matsuzaki; Eiji Kobayashi; Toshitaka Morishima; Isao Miyashiro; Keisuke Fukui; Yuri Ito; Tomio Nakayama; Tadashi Kimura
Correction
Correction: Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma
Weikun Xiao; Rongyu Zhang; Alireza Sohrabi; Arshia Ehsanipour; Songping Sun; Jesse Liang; Christopher M. Walthers; Lisa Ta; David A. Nathanson; Stephanie K. Seidlits
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