Wnt signaling is one of several signaling pathways that control homeostasis of the gastric epithelium. Aberrant activation of Wnt signaling promotes increased cell proliferation and is frequently observed in many cancers, including gastric cancer. This deregulation can occur in several ways, including mutations to Wnt regulators such as Apc or upregulation of Wnt ligands and/or Frizzled (Fzd) Wnt receptors. Using immunofluorescence, it was shown that targeting Fzd7 prevented gastric tumor cells from responding to oncogenic Wnt signaling and consequently inhibited their growth. This was observed in gastric tumors with or without Apc mutations, or those induced specifically by hyperactive gp130/Stat3 signaling. For details, see article by Flanagan and colleagues on page 970.