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15 February 2019
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Cover Image
Cover Image
Cancer cachexia describes the muscle wasting and weakness that robs many patients with cancer of their strength and capacity to perform daily tasks and to live independently. Activation of the mitochondrial assembly receptor (MasR) had multiple benefits for tumor-bearing mice with cancer cachexia, including attenuated tumor development, reduced weight loss, slowed muscle wasting, and improved locomotor activity. MasR-mediated protection against muscle wasting was conferred through preservation of the large, fast muscle fibers. For details, see article by Murphy and colleagues on page 706. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Molecular Cell Biology
SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program
Michael U.J. Oliphant; Melanie Y. Vincent; Matthew D. Galbraith; Ahwan Pandey; Vadym Zaberezhnyy; Pratyaydipta Rudra; Katherine R. Johnson; James C. Costello; Debashis Ghosh; James DeGregori; Joaquin M. Espinosa; Heide L. Ford
Tumor Biology and Immunology
Author Choice
Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer
Jagmohan Hooda; Marián Novak; Matthew P. Salomon; Chikako Matsuba; Romela I. Ramos; Emily MacDuffie; Melissa Song; Michelle S. Hirsch; Jenny Lester; Vinita Parkash; Beth Y. Karlan; Moshe Oren; Dave S. Hoon; Ronny Drapkin
Author Choice
Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis
Hoibin Jeong; Sehui Kim; Beom-Ju Hong; Chan-Ju Lee; Young-Eun Kim; Seoyeon Bok; Jung-Min Oh; Seung-Hee Gwak; Min Young Yoo; Min Sun Lee; Seock-Jin Chung; Joan Defrêne; Philippe Tessier; Martin Pelletier; Hyeongrin Jeon; Tae-Young Roh; Bumju Kim; Ki Hean Kim; Ji Hyeon Ju; Sungjee Kim; Yoon-Jin Lee; Dong-Wan Kim; Il Han Kim; Hak Jae Kim; Jong-Wan Park; Yun-Sang Lee; Jae Sung Lee; Gi Jeong Cheon; Irving L. Weissman; Doo Hyun Chung; Yoon Kyung Jeon; G-One Ahn
Translational Science
Convergence and Technologies
Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors
Matthias Eder; Silvia Pavan; Ulrike Bauder-Wüst; Katerine van Rietschoten; Ann-Christin Baranski; Helen Harrison; Spencer Campbell; Catherine L. Stace; Edward H. Walker; Liuhong Chen; Gavin Bennett; Gemma Mudd; Ursula Schierbaum; Karin Leotta; Uwe Haberkorn; Klaus Kopka; Daniel P. Teufel
Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity
Patrick N. McCormick; Hannah E. Greenwood; Matthias Glaser; Oliver D.K. Maddocks; Thibault Gendron; Kerstin Sander; Gayatri Gowrishankar; Aileen Hoehne; Tong Zhang; Adam J. Shuhendler; David Y. Lewis; Mathias Berndt; Norman Koglin; Mark F. Lythgoe; Sanjiv S. Gambhir; Erik Årstad; Timothy H. Witney
[18F]FSPG PET imaging provides a sensitive noninvasive measure of tumor redox status and provides an early marker of tumor response to therapy.
Population and Prevention Science
Corrections
Correction: Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer
Ariella B. Hanker; Mónica Valeria Estrada; Giampaolo Bianchini; Preston D. Moore; Junfei Zhao; Feixiong Cheng; James P. Koch; Luca Gianni; Darren R. Tyson; Violeta Sánchez; Brent N. Rexer; Melinda E. Sanders; Zhongming Zhao; Thomas P. Stricker; Carlos L. Arteaga
Correction: Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer
Valerie M. Jansen; Neil E. Bhola; Joshua A. Bauer; Luigi Formisano; Kyung-Min Lee; Katherine E. Hutchinson; Agnieszka K. Witkiewicz; Preston D. Moore; Mónica Valéria Estrada; Violeta Sánchez; Paula G. Ericsson; Melinda E. Sanders; Paula R. Pohlmann; Michael J. Pishvaian; David A. Riddle; Teresa C. Dugger; Wenyi Wei; Erik S. Knudsen; Carlos L. Arteaga
Correction: Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Neil E. Bhola; Valerie M. Jansen; Sangeeta Bafna; Jennifer M. Giltnane; Justin M. Balko; Mónica V. Estrada; Ingrid Meszoely; Ingrid Mayer; Vandana Abramson; Fei Ye; Melinda Sanders; Teresa C. Dugger; Eliezer V. Allen; Carlos L. Arteaga
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