Issues
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The molecular machinery governing cell polarity controls various aspects of cell behaviors including directional migration of cells under monolayer culture conditions. Immunofluorescence revealed that the Par-1 kinase, a critical component of the polarity-regulating machinery, is enriched on the lateral side of such migrating cells. However, in cells that were surrounded by extracellular matrix proteins, including tumor cells that have recently extravasated into the parenchyma of foreign tissues during metastasis, the Par-1 kinase was diffusely distributed throughout the cytosol. In these cells, cytosolically distributed Par-1 interfered with the critical signaling pathway driving cell proliferation, accounting for the difficulty of the recently extravasated tumor cells to initiate rapid proliferation. For details, see the article by Shibue and colleagues on page 5944. - PDF Icon PDF LinkTable of Contents
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Cancer Research
Table of Contents
Breaking Insights
Reviews
Cancer Research Highlights
Priority Report
BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents
Genome and Epigenome
Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
Molecular Cell Biology
Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance
Tumor Biology and Immunology
Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity
Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host–Virus Interactions
Translational Science
Convergence and Technologies
Editor’s Note
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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