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1 December 2019
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The molecular machinery governing cell polarity controls various aspects of cell behaviors including directional migration of cells under monolayer culture conditions. Immunofluorescence revealed that the Par-1 kinase, a critical component of the polarity-regulating machinery, is enriched on the lateral side of such migrating cells. However, in cells that were surrounded by extracellular matrix proteins, including tumor cells that have recently extravasated into the parenchyma of foreign tissues during metastasis, the Par-1 kinase was diffusely distributed throughout the cytosol. In these cells, cytosolically distributed Par-1 interfered with the critical signaling pathway driving cell proliferation, accounting for the difficulty of the recently extravasated tumor cells to initiate rapid proliferation. For details, see the article by Shibue and colleagues on page 5944.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Reviews
Cancer Research Highlights
Priority Report
BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents
Arun Kanakkanthara; Kiran Kurmi; Thomas L. Ekstrom; Xiaonan Hou; Emma R. Purfeerst; Ethan P. Heinzen; Cristina Correia; Catherine J. Huntoon; Daniel O'Brien; Andrea E. Wahner Hendrickson; Sean C. Dowdy; Hu Li; Ann L. Oberg; Taro Hitosugi; Scott H. Kaufmann; S. John Weroha; Larry M. Karnitz
Genome and Epigenome
Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
Rui You; You-Ping Liu; De-Chen Lin; Qing Li; Tao Yu; Xiong Zou; Mei Lin; Xiao-Long Zhang; Gui-Ping He; Qi Yang; Yi-Nuan Zhang; Yu-Long Xie; Rou Jiang; Chen-Yan Wu; Chao Zhang; Cheng Cui; Jing-Qi Wang; Yue Wang; Ai-Hua Zhuang; Gui-Fang Guo; Yi-Jun Hua; Rui Sun; Jing-Ping Yun; Zhi-Xiang Zuo; Ze-Xian Liu; Xiao-Feng Zhu; Tie-Bang Kang; Chao-Nan Qian; Hai-Qiang Mai; Ying Sun; Mu-Sheng Zeng; Lin Feng; Yi-Xin Zeng; Ming-Yuan Chen
Molecular Cell Biology
Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance
Antoine Bernard; Sandy Chevrier; Françoise Beltjens; Magalie Dosset; Etienne Viltard; Anaïs Lagrange; Valentin Derangère; Alexandra Oudot; François Ghiringhelli; Bertrand Collin; Lionel Apetoh; Olivier Feron; Suzie Chen; Laurent Arnould; Frédérique Végran; Romain Boidot
Tumor Biology and Immunology
Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity
Sathya Muralidhar; Anastasia Filia; Jérémie Nsengimana; Joanna Poźniak; Sally J. O'Shea; Joey M. Diaz; Mark Harland; Juliette A. Randerson-Moor; Jörg Reichrath; Jonathan P. Laye; Louise van der Weyden; David J. Adams; D.T. Bishop; Julia Newton-Bishop
Author Choice
Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host–Virus Interactions
Srishti Chakravorty; Bingyu Yan; Chong Wang; Luopin Wang; Joseph Taylor Quaid; Chin Fang Lin; Scott D. Briggs; Joydeb Majumder; D. Alejandro Canaria; Daniel Chauss; Gaurav Chopra; Matthew R. Olson; Bo Zhao; Behdad Afzali; Majid Kazemian
Translational Science
Convergence and Technologies
Editor’s Note
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