Skip Nav Destination
Issues
1 October 2019
-
Cover Image
Cover Image
Super-resolution live-cell imaging shows colocalization of GLK-mGFP and IQGAP1-Tomato fusion proteins predominantly at the leading edge of a migrating human HCC827 lung adenocarcinoma cell. The predominantly leading-edge colocalization of GLK and IQGAP1 cannot be determined by a conventional confocal microscope due to the resolution limit of light microscopes. The super-resolution live-cell imaging accelerates the precise understanding of molecular mechanisms in GLK-IQGAP1–induced cell migration and cancer metastasis. For details, see article by Chuang and colleagues on page 4978.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Cancer Research Highlights
Genome and Epigenome
Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas
Fumiharu Ohka; Keiko Shinjo; Shoichi Deguchi; Yusuke Matsui; Yusuke Okuno; Keisuke Katsushima; Miho Suzuki; Akira Kato; Noboru Ogiso; Akane Yamamichi; Kosuke Aoki; Hiromichi Suzuki; Shinya Sato; Nirmala Arul Rayan; Shyam Prabhakar; Jonathan Göke; Teppei Shimamura; Reo Maruyama; Satoru Takahashi; Akio Suzumura; Hiroshi Kimura; Toshihiko Wakabayashi; Hui Zong; Atsushi Natsume; Yutaka Kondo
ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer
Steffan Vartanian; James Lee; Christiaan Klijn; Florian Gnad; Maria Bagniewska; Gabriele Schaefer; Donglu Zhang; Jenille Tan; Sara A. Watson; Liling Liu; Honglin Chen; Yuxin Liang; Colin Watanabe; Trinna Cuellar; David Kan; Ryan J. Hartmaier; Ted Lau; Michael R. Costa; Scott E. Martin; Mark Merchant; Benjamin Haley; David Stokoe
Author Choice
The Open Chromatin Landscape of Non–Small Cell Lung Carcinoma
Zhoufeng Wang; Kailing Tu; Lin Xia; Kai Luo; Wenxin Luo; Jie Tang; Keying Lu; Xinlei Hu; Yijing He; Wenliang Qiao; Yongzhao Zhou; Jun Zhang; Feng Cao; Shuiping Dai; Panwen Tian; Ye Wang; Lunxu Liu; Guowei Che; Qinghua Zhou; Dan Xie; Weimin Li
Metabolism and Chemical Biology
Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells
Johanna Erber; Joachim D. Steiner; Jörg Isensee; Leonard A. Lobbes; André Toschka; Filippo Beleggia; Anna Schmitt; Rainer W. J. Kaiser; Florian Siedek; Thorsten Persigehl; Tim Hucho; Hans C. Reinhardt
Molecular Cell Biology
BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail
Zhong-yi Qin; Tao Wang; Siyuan Su; Li-ting Shen; Guang-xi Zhu; Qin Liu; Liang Zhang; Ke-wei Liu; Yue Zhang; Zhi-hua Zhou; Xiao-ning Zhang; Liang-zhi Wen; Yue-liang Yao; Wen-jing Sun; Yan Guo; Kai-jun Liu; Lei Liu; Xing-wei Wang; Yan-ling Wei; Jun Wang; Hua-liang Xiao; Pengda Liu; Xiu-wu Bian; Dong-feng Chen; Bin Wang
MDM2 Derived from Dedifferentiated Liposarcoma Extracellular Vesicles Induces MMP2 Production from Preadipocytes
Lucia Casadei; Federica Calore; Danielle A. Braggio; Abeba Zewdu; Ameya A. Deshmukh; Paolo Fadda; Gonzalo Lopez; Martin Wabitsch; Chi Song; Jennifer L. Leight; Valerie P. Grignol; Dina Lev; Carlo M. Croce; Raphael E. Pollock
DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing
Songge Xing; Zhaoyong Li; Wenhao Ma; Xiaoping He; Shengqi Shen; Haoran Wei; Shi-Ting Li; Ying Shu; Linchong Sun; Xiuying Zhong; Yuhao Huangfu; Lanhong Su; Junru Feng; Xiaozhang Zhang; Ping Gao; Wei-Dong Jia; Huafeng Zhang
LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion
Xiu-Hui Zhan; Ji-Wei Jiao; Hai-Feng Zhang; Xiu-E Xu; Jian-Zhong He; Run-Liu Li; Hai-Ying Zou; Zhi-Yong Wu; Shao-Hong Wang; Jian-Yi Wu; Lian-Di Liao; Juan-Juan Wang; Yin-Wei Cheng; Kai Zhang; Gera Neufeld; Li-Yan Xu; En-Min Li
Tumor Biology and Immunology
Author Choice
Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E
Ying Zhang; Stefan Pusch; James Innes; Kastytis Sidlauskas; Matthew Ellis; Joanne Lau; Tedani El-Hassan; Natasha Aley; Francesca Launchbury; Angela Richard-Loendt; Jasper deBoer; Sheng Chen; Lei Wang; Andreas von Deimling; Ningning Li; Sebastian Brandner
Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Mercedes Tomé; Angela Pappalardo; Fabienne Soulet; José Javier López; Jone Olaizola; Yannick Leger; Marielle Dubreuil; Amandine Mouchard; Delphine Fessart; Frédéric Delom; Vincent Pitard; Dominique Bechade; Mariane Fonck; Juan Antonio Rosado; François Ghiringhelli; Julie Déchanet-Merville; Isabelle Soubeyran; Geraldine Siegfried; Serge Evrard; Abdel-Majid Khatib
The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy
Kostyantyn Krysan; Linh M. Tran; Brandon S. Grimes; Gregory A. Fishbein; Atsuko Seki; Brian K. Gardner; Tonya C. Walser; Ramin Salehi-Rad; Jane Yanagawa; Jay M. Lee; Sherven Sharma; Denise R. Aberle; Arum E. Spira; David A. Elashoff; William D. Wallace; Michael C. Fishbein; Steven M. Dubinett
AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells
Jimena Trillo-Tinoco; Rosa A. Sierra; Eslam Mohamed; Yu Cao; Álvaro de Mingo-Pulido; Danielle L. Gilvary; Carmen M. Anadon; Tara Lee Costich; Sheng Wei; Elsa R. Flores; Brian Ruffell; José R. Conejo-Garcia; Paulo C. Rodriguez
Translational Science
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
Choh Yeung; Anna E. Gibson; Sameer H. Issaq; Nobu Oshima; Joshua T. Baumgart; Leah D. Edessa; Ganesha Rai; Daniel J. Urban; Michelle S. Johnson; Gloria A. Benavides; Giuseppe L. Squadrito; Marielle E. Yohe; Haiyan Lei; Sandy Eldridge; John Hamre, III; Tyrone Dowdy; Victor Ruiz-Rodado; Adrian Lita; Arnulfo Mendoza; Jack F. Shern; Mioara Larion; Lee J. Helman; Gordon M. Stott; Murali C. Krishna; Matthew D. Hall; Victor Darley-Usmar; Leonard M. Neckers; Christine M. Heske
Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma
Charlotte R. Feddersen; Jacob L. Schillo; Afshin Varzavand; Hayley R. Vaughn; Lexy S. Wadsworth; Andrew P. Voigt; Eliot Y. Zhu; Brooke M. Jennings; Sarah A. Mullen; Jeremy Bobera; Jesse D. Riordan; Christopher S. Stipp; Adam J. Dupuy
Tie2–FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma
Xiaolong Li; Emmanuel Martinez-Ledesma; Chen Zhang; Feng Gao; Siyuan Zheng; Jie Ding; Shaofang Wu; Nghi Nguyen; Stephan C. Clifford; Patrick Y. Wen; Keith L. Ligon; W.K. Alfred Yung; Dimpy Koul
Convergence and Technologies
Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data
Emily F. Davis-Marcisak; Thomas D. Sherman; Pranay Orugunta; Genevieve L. Stein-O'Brien; Sidharth V. Puram; Evanthia T. Roussos Torres; Alexander C. Hopkins; Elizabeth M. Jaffee; Alexander V. Favorov; Bahman Afsari; Loyal A. Goff; Elana J. Fertig
Population and Prevention Science
Letters to the Editor
Correction
Editor’s Note
Advertisement