YAP nuclear translocation and activation regulate cellular proliferation and growth of some solid tumors. Rab11, a family of small GTPases that control the recycling endosome-mediated protein trafficking, restrains YAP localization at apical junctions and cytoplasm in mature epithelial cells. During colonic tumorigenesis, loss of Rab11 function diminishes Hippo kinase activities, leading to increased YAP nuclear translocation and accelerated tumor growth. For details, see article by D'Agostino and colleagues on page 4099.