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15 August 2019
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YAP nuclear translocation and activation regulate cellular proliferation and growth of some solid tumors. Rab11, a family of small GTPases that control the recycling endosome-mediated protein trafficking, restrains YAP localization at apical junctions and cytoplasm in mature epithelial cells. During colonic tumorigenesis, loss of Rab11 function diminishes Hippo kinase activities, leading to increased YAP nuclear translocation and accelerated tumor growth. For details, see article by D'Agostino and colleagues on page 4099.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Reviews
Cancer Research Highlights
Controversy and Consensus
Molecular Cell Biology
MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells
Bikul Das; Bidisha Pal; Rashmi Bhuyan; Hong Li; Anupam Sarma; Sukanya Gayan; Joyeeta Talukdar; Sorra Sandhya; Seema Bhuyan; Gayatri Gogoi; Arvin M. Gouw; Debabrat Baishya; Jason R. Gotlib; Amal C. Kataki; Dean W. Felsher
Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas
Robert F. Koncar; Brittany R. Dey; Ann-Catherine J. Stanton; Nishant Agrawal; Michelle L. Wassell; Lauren H. McCarl; Abigail. L. Locke; Lauren Sanders; Olena Morozova-Vaske; Max I. Myers; Ronald L. Hamilton; Angel M. Carcaboso; Gary Kohanbash; Baoli Hu; Nduka M. Amankulor; James Felker; Madhuri Kambhampati; Javad Nazarian; Oren J. Becher; C. David James; Rintaro Hashizume; Alberto Broniscer; Ian F. Pollack; Sameer Agnihotri
Author Choice
The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2
Nina Kozlova; Daniela Mennerich; Anatoly Samoylenko; Elitsa Y. Dimova; Peppi Koivunen; Ekaterina Biterova; Kati Richter; Antti Hassinen; Sakari Kellokumpu; Aki Manninen; Ilkka Miinalainen; Virpi Glumoff; Lloyd Ruddock; Lyudmyla Borysivna Drobot; Thomas Kietzmann
ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Rohit Sachdeva; Megan Wu; Sandra Smiljanic; Oleksandra Kaskun; Kimia Ghannad-Zadeh; Angela Celebre; Keren Isaev; A. Sorana Morrissy; Jennifer Guan; Jiefei Tong; Jeffrey Chan; Taylor M. Wilson; Sayf Al-Omaishi; David G. Munoz; Peter B. Dirks; Michael F. Moran; Michael D. Taylor; Jüri Reimand; Sunit Das
Author Choice
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling
Luca D'Agostino; Yingchao Nie; Sayantani Goswami; Kevin Tong; Shiyan Yu; Sheila Bandyopadhyay; Juan Flores; Xiao Zhang; Iyshwarya Balasubramanian; Ivor Joseph; Ryotaro Sakamori; Victoria Farrell; Qi Li; Chung S. Yang; Bin Gao; Ronaldo P. Ferraris; Ghassan Yehia; Edward M. Bonder; James R. Goldenring; Michael P. Verzi; Lanjing Zhang; Y. Tony Ip; Nan Gao
Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models
Anna-Mariya Kukuyan; Eleonora Sementino; Yuwaraj Kadariya; Craig W. Menges; Mitchell Cheung; Yinfei Tan; Kathy Q. Cai; Michael J. Slifker; Suraj Peri; Andres J. Klein-Szanto; Frank J. Rauscher, III; Joseph R. Testa
p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation That Is Required for GSK3β-βTrCP–Induced Snail Degradation
Ki-Jun Ryu; Sun-Mi Park; Seung-Ho Park; In-Kyu Kim; Hyeontak Han; Hyo-Jin Kim; Seon-Hee Kim; Keun-Seok Hong; Hyemin Kim; Minju Kim; Sung-Jin Yoon; Killivalavan Asaithambi; Kon Ho Lee; Jae-Yong Park; Young-Sool Hah; Hee Jun Cho; Jong In Yook; Jung Wook Yang; Gyung-Hyuck Ko; Gyemin Lee; Yang Jae Kang; Cheol Hwangbo; Kwang Dong Kim; Young-Jun Park; Jiyun Yoo
Tumor Biology and Immunology
Author Choice
EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis
Guillermo Peluffo; Ashim Subedee; Nicholas W. Harper; Natalie Kingston; Bojana Jovanović; Felipe Flores; Laura E. Stevens; Francisco Beca; Anne Trinh; Chandra Sekhar Reddy Chilamakuri; Evangelia K. Papachristou; Katherine Murphy; Ying Su; Andriy Marusyk; Clive S. D'Santos; Oscar M. Rueda; Andrew H. Beck; Carlos Caldas; Jason S. Carroll; Kornelia Polyak
Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer
Carlotta Tacconi; Federica Ungaro; Carmen Correale; Vincenzo Arena; Luca Massimino; Michael Detmar; Antonino Spinelli; Michele Carvello; Massimiliano Mazzone; Ana I. Oliveira; Federica Rubbino; Valentina Garlatti; Salvatore Spanò; Enrico Lugli; Federico S. Colombo; Alberto Malesci; Laurent Peyrin-Biroulet; Stefania Vetrano; Silvio Danese; Silvia D’Alessio
The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis
Sarah E. Taylor; Caitlin M. O'Connor; Zhizhi Wang; Guobo Shen; Haichi Song; Daniel Leonard; Jaya Sangodkar; Corinne LaVasseur; Stefanie Avril; Steven Waggoner; Kristine Zanotti; Amy J. Armstrong; Christa Nagel; Kimberly Resnick; Sareena Singh; Mark W. Jackson; Wenqing Xu; Shozeb Haider; Analisa DiFeo; Goutham Narla
Translational Science
Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
Jorge Gómez-Miragaya; Ander Díaz-Navarro; Raul Tonda; Sergi Beltran; Luis Palomero; Marta Palafox; Lacey E. Dobrolecki; Chen Huang; Suhas Vasaikar; Bing Zhang; Gerburg M. Wulf; Alejandro Collado-Sole; Eva M. Trinidad; Purificación Muñoz; Laia Paré; Aleix Prat; Alejandra Bruna; Carlos Caldas; Joaquín Arribas; María Teresa Soler-Monso; Anna Petit; Judith Balmaña; Cristina Cruz; Violeta Serra; Miguel Angel Pujana; Michael T. Lewis; Xose S. Puente; Eva González-Suárez
Convergence and Technologies
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Xiaoran Lai; Oliver M. Geier; Thomas Fleischer; Øystein Garred; Elin Borgen; Simon W. Funke; Surendra Kumar; Marie E. Rognes; Therese Seierstad; Anne-Lise Børresen-Dale; Vessela N. Kristensen; Olav Engebraaten; Alvaro Köhn-Luque; Arnoldo Frigessi
Editor’s Notes
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