Issues
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Cover Image
Cover Image
YAP nuclear translocation and activation regulate cellular proliferation and growth of some solid tumors. Rab11, a family of small GTPases that control the recycling endosome-mediated protein trafficking, restrains YAP localization at apical junctions and cytoplasm in mature epithelial cells. During colonic tumorigenesis, loss of Rab11 function diminishes Hippo kinase activities, leading to increased YAP nuclear translocation and accelerated tumor growth. For details, see article by D'Agostino and colleagues on page 4099. - PDF Icon PDF LinkTable of Contents
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Cancer Research
Table of Contents
Breaking Insights
Reviews
Cancer Research Highlights
Controversy and Consensus
Molecular Cell Biology
MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells
Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas
The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2
ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling
Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models
p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation That Is Required for GSK3β-βTrCP–Induced Snail Degradation
Tumor Biology and Immunology
EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis
Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer
The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis
Translational Science
Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
Convergence and Technologies
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Editor’s Notes
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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