Mouse models for gliomas shed light on the importance of cell of origin, progression, heterogeneity, and the tumor stroma that cannot be easily studied in human cancers. GFAP-FLPo mouse strain expresses FLPo recombinase exclusively in GFAP-positive cells in the brain, which allows restriction of the initial sources of cell of origin of gliomas with the lentiviral delivery of cancer genes. Furthermore, this glioma model enables additional manipulation of mouse genome mediated by Cre recombinase in any cell type at any time in vivo and, therefore, accelerates the precise understanding of cellular and molecular mechanisms in the developmental processes of this deadly disease. For details, see article by Hara and Verma on page 3983.