A 44-year-old Caucasian female was diagnosed with invasive ductal carcinoma: grade III; pT1c, 1.8 cm; pN1, 1/17; pMx; ER+ (>90%), PR+ (25%), HER2− (1+). Using QG2 assay, the expression level of IGF1R mRNA in this tumor sample was found to be 87.1. Based on GMM minimal misclassification (cutoff = 57.0) and confidence (cutoff > 66.0), this tumor was classified as cancer overexpressing IGF1R. Using immunohistochemistry and the COMPAi-generated tissue segmentation map (tumor, red; stroma, green; other regions, purple), it was found that the IGF1R protein level was also upregulated, thus confirming model-predicted classification of this cancer. For details, see article by Prabakaran and colleagues on page 3492.