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Volume 79, Issue 1
1 January 2019
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    Cover Image

    issue cover
    Whole mount images of a mouse mammary glands stained with Carmine alum after being isolated from nulliparous PRMT6Tg at 7 months of age. Note the hyperbranching of the mammary ducts in the K5-PRMT6Tg mammary gland. For details, see article by Bao and colleagues on page 21.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Insights

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Cancer Research Highlights

Type I Protein Arginine Methyltransferases Overexpression Promotes Transformation and Potentiates Her2/Neu–Driven Tumorigenesis
Zachary L. Watson; Benjamin G. Bitler
View articletitled, Type I Protein Arginine Methyltransferases Overexpression Promotes Transformation and Potentiates Her2/Neu–Driven Tumorigenesis
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Time for a “Plan B” in Peritoneal Metastatic Disease
Claudio Tripodo
View articletitled, Time for a “Plan B” in Peritoneal Metastatic Disease
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Genome and Epigenome

Author Choice
Multiregion Sequencing Reveals the Genetic Heterogeneity and Evolutionary History of Osteosarcoma and Matched Pulmonary Metastases
Di Wang; Xiaohui Niu; Zhijie Wang; Cheng-Li Song; Zhen Huang; Ke-Neng Chen; Jianchun Duan; Hua Bai; Jiachen Xu; Jun Zhao; Yu Wang; Minglei Zhuo; X. Sunney Xie; Xiaozheng Kang; Yanhua Tian; Liangliang Cai; Jie-Fei Han; Tongtong An; Yu Sun; Shugeng Gao; Jun Zhao; Jianming Ying; Luhua Wang; Jie He; Jie Wang
View articletitled, Multiregion Sequencing Reveals the Genetic Heterogeneity and Evolutionary History of Osteosarcoma and Matched Pulmonary Metastases
Supplementary data
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Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases
Jianqiang Bao; Alessandra Di Lorenzo; Kevin Lin; Yue Lu; Yi Zhong; Manu M. Sebastian; William J. Muller; Yanzhong Yang; Mark T. Bedford
View articletitled, Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases
Supplementary data
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Molecular Cell Biology

TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1
Guillem Lambies; Martina Miceli; Catalina Martínez-Guillamon; Rubén Olivera-Salguero; Raúl Peña; Carolina-Paola Frías; Irene Calderón; Boyko S. Atanassov; Sharon Y. R. Dent; Joaquín Arribas; Antonio García de Herreros; Víctor M. Díaz
View articletitled, TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1
Supplementary data
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CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Azadeh Nilchian; Joel Johansson; Aram Ghalali; Sandra T. Asanin; Ana Santiago; Oskar Rosencrantz; Kerstin Sollerbrant; C. Theresa Vincent; Malin Sund; Ulla Stenius; Jonas Fuxe
View articletitled, CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Supplementary data
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Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes
Wen Bu; Zhenyu Liu; Weiyu Jiang; Chandandeep Nagi; Shixia Huang; Dean P. Edwards; Eunji Jo; Qianxing Mo; Chad J. Creighton; Susan G. Hilsenbeck; Andrew D. Leavitt; Michael T. Lewis; Stephen T. C. Wong; Yi Li
View articletitled, Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes
Supplementary data
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Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2
Li Ma; Kangyu Lin; Guoqiang Chang; Yiwen Chen; Chen Yue; Qing Guo; Sicong Zhang; Zhiliang Jia; Tony T. Huang; Aidong Zhou; Suyun Huang
View articletitled, Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2
Supplementary data
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Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1
Ying Xiang; Kai Yan; Qian Zheng; Haiqiang Ke; Jie Cheng; Wenjun Xiong; Xin Shi; Lei Wei; Min Zhao; Fei Yang; Ping Wang; Xing Lu; Li Fu; Xuemei Lu; Feng Li
View articletitled, Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1
Supplementary data
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Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB
Dorthe Aasland; Laura Götzinger; Laura Hauck; Nancy Berte; Jessica Meyer; Melanie Effenberger; Simon Schneider; Emelie E. Reuber; Wynand P. Roos; Maja T. Tomicic; Bernd Kaina; Markus Christmann
View articletitled, Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB
Supplementary data
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Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice
Tianxiang Hu; Yating Chong; Sumin Lu; Haiyan Qin; Mingqiang Ren; Natasha M. Savage; Chang-Sheng Chang; John K Cowell
View articletitled, Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice
Supplementary data
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Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis
Xiang Yan; Xiaoshan Zhang; Li Wang; Ran Zhang; Xingxiang Pu; Shuhong Wu; Lei Li; Pan Tong; Jing Wang; Qing H. Meng; Vanessa B. Jensen; Luc Girard; John D. Minna; Jack A. Roth; Stephen G. Swisher; John V. Heymach; Bingliang Fang
View articletitled, Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis
Supplementary data
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Author Choice
PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells
Chen Liang; Si Shi; Mingyang Liu; Yi Qin; Qingcai Meng; Jie Hua; Shunrong Ji; Yuqing Zhang; Jingxuan Yang; Jin Xu; Quanxing Ni; Min Li; Xianjun Yu
View articletitled, PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells
Supplementary data
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Tumor Biology and Immunology

Author Choice
M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer
Jingqin Lan; Li Sun; Feng Xu; Lu Liu; Fuqing Hu; Da Song; Zhenlin Hou; Wei Wu; Xuelai Luo; Jing Wang; Xianglin Yuan; Junbo Hu; Guihua Wang
View articletitled, M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer
Supplementary data
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Activation of B-1 Cells Promotes Tumor Cell Killing in the Peritoneal Cavity
Marcela A. Haro; Allison M. Dyevoich; James P. Phipps; Karen M. Haas
View articletitled, Activation of B-1 Cells Promotes Tumor Cell Killing in the Peritoneal Cavity
Supplementary data
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Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1
Thomas A. Werfel; David L. Elion; Bushra Rahman; Donna J. Hicks; Violeta Sanchez; Paula I. Gonzales-Ericsson; Mellissa J. Nixon; Jamaal L. James; Justin M. Balko; Peggy A. Scherle; Holly K. Koblish; Rebecca S. Cook
View articletitled, Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1
Supplementary data
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miR-146a Controls Immune Response in the Melanoma Microenvironment
Justin Mastroianni; Natalie Stickel; Hana Andrlova; Kathrin Hanke; Wolfgang Melchinger; Sandra Duquesne; Dominik Schmidt; Martina Falk; Geoffroy Andrieux; Dietmar Pfeifer; Heide Dierbach; Annette Schmitt-Graeff; Frank Meiss; Melanie Boerries; Robert Zeiser
View articletitled, miR-146a Controls Immune Response in the Melanoma Microenvironment
Supplementary data
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Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer
Srikanth R. Polusani; Yi-Wen Huang; Guangcun Huang; Chun-Wei Chen; Chiou-Miin Wang; Li-Ling Lin; Pawel Osmulski; Nicholas D. Lucio; Lu Liu; Ya-Ting Hsu; Yufan Zhou; Chun-Lin Lin; Irene Aguilera-Barrantes; Philip T. Valente; Edward R. Kost; Chun-Liang Chen; Eun Yong Shim; Sang Eun Lee; Jianhua Ruan; Maria E. Gaczynska; Pearlly Yan; Paul J. Goodfellow; David G. Mutch; Victor X. Jin; Bruce J. Nicholson; Tim H.-M. Huang; Nameer B. Kirma
View articletitled, Adipokines Deregulate Cellular Communication via Epigenetic Repression of <em>Gap Junction</em> Loci in Obese Endometrial Cancer
Supplementary data
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Translational Science

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma
Brittany L. Allen-Petersen; Tyler Risom; Zipei Feng; Zhiping Wang; Zina P. Jenny; Mary C. Thoma; Katherine R. Pelz; Jennifer P. Morton; Owen J. Sansom; Charles D. Lopez; Brett Sheppard; Dale J. Christensen; Michael Ohlmeyer; Goutham Narla; Rosalie C. Sears
View articletitled, Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma
Supplementary data
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Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models
Richard Mair; Florent Mouliere; Christopher G. Smith; Dineika Chandrananda; Davina Gale; Francesco Marass; Dana W.Y. Tsui; Charles E. Massie; Alan J. Wright; Colin Watts; Nitzan Rosenfeld; Kevin M. Brindle
View articletitled, Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models
Supplementary data
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Genetic Variants of VEGFA and FLT4 Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib
Daniel J. Crona; Andrew D. Skol; Veli-Matti Leppänen; Dylan M. Glubb; Amy S. Etheridge; Eleanor Hilliard; Carol E. Peña; Yuri K. Peterson; Nancy Klauber-DeMore; Kari K. Alitalo; Federico Innocenti
View articletitled, Genetic Variants of <em>VEGFA</em> and <em>FLT4</em> Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib
Supplementary data
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Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models
Yiyu Dong; Roozbeh Eskandari; Chelsea Ray; Kristin L. Granlund; Lidia Dos Santos-Cunha; Vesselin Z. Miloushev; Sui Seng Tee; Sangmoo Jeong; Omer Aras; Ying-Bei Chen; Emily H. Cheng; James J. Hsieh; Kayvan R. Keshari
View articletitled, Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models
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MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
John Hines; Schan Lartigue; Hanqing Dong; Yimin Qian; Craig M. Crews
View articletitled, MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
Supplementary data
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Convergence and Technologies

Author Choice
A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT
Andrew V. Kossenkov; Rehman Qureshi; Noor B. Dawany; Jayamanna Wickramasinghe; Qin Liu; R. Sonali Majumdar; Celia Chang; Sandy Widura; Trisha Kumar; Wen-Hwai Horng; Eric Konnisto; Gerard Criner; Jun-Chieh J. Tsay; Harvey Pass; Sai Yendamuri; Anil Vachani; Thomas Bauer; Brian Nam; William N. Rom; Michael K. Showe; Louise C. Showe
View articletitled, A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT
Supplementary data
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Population and Prevention Science

Author Choice
A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk
Ruth C. Travis; Aurora Perez-Cornago; Paul N. Appleby; Demetrius Albanes; Corinne E. Joshu; Pamela L. Lutsey; Alison M. Mondul; Elizabeth A. Platz; Stephanie J. Weinstein; Tracy M. Layne; Kathy J. Helzlsouer; Kala Visvanathan; Domenico Palli; Petra H. Peeters; Bas Bueno-de-Mesquita; Antonia Trichopoulou; Marc J. Gunter; Konstantinos K. Tsilidis; Maria-Jose Sánchez; Anja Olsen; Hermann Brenner; Ben Schöttker; Laura Perna; Bernd Holleczek; Paul Knekt; Harri Rissanen; Bu B. Yeap; Leon Flicker; Osvaldo P. Almeida; Yuen Yee Elizabeth Wong; June M. Chan; Edward L. Giovannucci; Meir J. Stampfer; Giske Ursin; Randi E. Gislefoss; Tone Bjørge; Haakon E. Meyer; Rune Blomhoff; Shoichiro Tsugane; Norie Sawada; Dallas R. English; Darryl W. Eyles; Alicia K. Heath; Elizabeth J. Williamson; Jonas Manjer; Johan Malm; Martin Almquist; Loic Le Marchand; Christopher A. Haiman; Lynne R. Wilkens; Jeannette M. Schenk; Cathy M. Tangen; Amanda Black; Michael B. Cook; Wen-Yi Huang; Regina G. Ziegler; Richard M. Martin; Freddie C. Hamdy; Jenny L. Donovan; David E. Neal; Mathilde Touvier; Serge Hercberg; Pilar Galan; Mélanie Deschasaux; Timothy J. Key; Naomi E. Allen
View articletitled, A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk
Supplementary data
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Corrections

Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Joanna L. Holmes; Swee Y. Sharp; Steve Hobbs; Paul Workman
View articletitled, Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
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Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors
Swee Y. Sharp; Kathy Boxall; Martin Rowlands; Chrisostomos Prodromou; S. Mark Roe; Alison Maloney; Marissa Powers; Paul A. Clarke; Gary Box; Sharon Sanderson; Lisa Patterson; Thomas P. Matthews; Kwai-Ming J. Cheung; Karen Ball; Angela Hayes; Florence Raynaud; Richard Marais; Laurence Pearl; Sue Eccles; Wynne Aherne; Edward McDonald; Paul Workman
View articletitled, Correction: <em>In vitro</em> Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors
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Acknowledgment to Reviewers

Acknowledgment to Reviewers
View articletitled, Acknowledgment to Reviewers
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