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Issues

Volume 78, Issue 9
1 May 2018
Cancer Research Cover Image for Volume 78, Issue 9
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  • Cover Image

    Cover Image

    Issue cover image
    Multinucleation is found in more than one third of tumors and is linked to increased tolerance for mutation, resistance to chemotherapy, and invasive potential. Tissue stiffening during tumorigenesis induces multinucleation in mammary epithelial cells. This phenomenon is exacerbated by increased levels of EMT-promoting transcription factor Snail, which causes midbody persistence and abscission failure. For details, see article by Simi and colleagues on page 2277.
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Insights

Highlights from Recent Cancer Literature
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Obituary

Jimmie C. Holland, MD: In Memoriam (1928–2017)
David W. Kissane
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Reviews

Hiding in Plain Sight: Rediscovering the Importance of Noncoding RNA in Human Malignancy
Kyle P. Feeley; Mick D. Edmonds
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Resistance to Antibody–Drug Conjugates
Sara García-Alonso; Alberto Ocaña; Atanasio Pandiella
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Controversy and Consensus

Author Choice
Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches—Meeting Viewpoint
Mansoor M. Ahmed; C. Norman Coleman; Marc Mendonca; Soren Bentzen; Bhadrasain Vikram; Stephen M. Seltzer; Dudley Goodhead; Ceferino Obcemea; Radhe Mohan; Kevin M. Prise; Jacek Capala; Deborah Citrin; Gary Kao; Molykutty Aryankalayil; Iris Eke; Jeffrey C. Buchsbaum; Pataje G.S. Prasanna; Fei-Fei Liu; Quynh-Thu Le; Beverly Teicher; David G. Kirsch; DeeDee Smart; Joel Tepper; Silvia Formenti; Daphne Haas-Kogan; David Raben; James Mitchell
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Priority Report

Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability
Bo Wei; Chao Huang; Bin Liu; Yang Wang; Nansong Xia; Qiuju Fan; Guo-Qiang Chen; Jinke Cheng
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Metabolism and Chemical Biology

Author Choice
Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma
Hideki Makinoshima; Shigeki Umemura; Ayako Suzuki; Hiroki Nakanishi; Ami Maruyama; Hibiki Udagawa; Sachiyo Mimaki; Shingo Matsumoto; Seiji Niho; Genichiro Ishii; Masahiro Tsuboi; Atsushi Ochiai; Hiroyasu Esumi; Takehiko Sasaki; Koichi Goto; Katsuya Tsuchihara
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RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Thibault Houles; Simon-Pierre Gravel; Geneviève Lavoie; Sejeong Shin; Mathilde Savall; Antoine Méant; Benoit Grondin; Louis Gaboury; Sang-Oh Yoon; Julie St-Pierre; Philippe P. Roux
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Molecular Cell Biology

Nuclear Receptor LRH-1 Functions to Promote Castration-Resistant Growth of Prostate Cancer via Its Promotion of Intratumoral Androgen Biosynthesis
Lijia Xiao; Yuliang Wang; Kexin Xu; Hao Hu; Zhenyu Xu; Dinglan Wu; Zhu Wang; Wenxing You; Chi-Fai Ng; Shan Yu; Franky Leung Chan
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Demethylation-Induced Overexpression of Shc3 Drives c-Raf–Independent Activation of MEK/ERK in HCC
Yun Liu; Xinran Zhang; Baicai Yang; Hao Zhuang; Hua Guo; Wen Wei; Yuan Li; Ruibing Chen; Yongmei Li; Ning Zhang
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Author Choice
A DDX31/Mutant–p53/EGFR Axis Promotes Multistep Progression of Muscle-Invasive Bladder Cancer
Kei Daizumoto; Tetsuro Yoshimaru; Yosuke Matsushita; Tomoya Fukawa; Hisanori Uehara; Masaya Ono; Masato Komatsu; Hiro-omi Kanayama; Toyomasa Katagiri
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Oncogenic Kinase–Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem–like Cells
Zhifen Zhou; Min Li; Lin Zhang; Hong Zhao; Özgür Şahin; Jing Chen; Jean J. Zhao; Zhou Songyang; Dihua Yu
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Proteolytic Release of the p75NTR Intracellular Domain by ADAM10 Promotes Metastasis and Resistance to Anoikis
Xin Bao; Jianbo Shi; Furong Xie; Zengying Liu; Jingshuang Yu; Wantao Chen; Zhiyuan Zhang; Qin Xu
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A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail
Allison K. Simi; Alişya A. Anlaş; Melody Stallings-Mann; Sherry Zhang; Tiffaney Hsia; Magdalena Cichon; Derek C. Radisky; Celeste M. Nelson
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2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas
Pavithra Viswanath; Marina Radoul; Jose Luis Izquierdo-Garcia; Wei Qiang Ong; Hema Artee Luchman; J. Gregory Cairncross; Bo Huang; Russell O. Pieper; Joanna J. Phillips; Sabrina M. Ronen
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Tumor Biology and Immunology

Featured Image
Author Choice
SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways
Yan-Li Zhang; Qing Li; Xiao-Mei Yang; Fang Fang; Jun Li; Ya-Hui Wang; Qin Yang; Lei Zhu; Hui-Zhen Nie; Xue-Li Zhang; Ming-Xuan Feng; Shu-Heng Jiang; Guang-Ang Tian; Li-Peng Hu; Ho-Young Lee; Su-Jae Lee; Qiang Xia; Zhi-Gang Zhang
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Author Choice
A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
David Díaz-Carballo; Sahitya Saka; Jacqueline Klein; Tobias Rennkamp; Ali H. Acikelli; Sascha Malak; Holger Jastrow; Gunther Wennemuth; Clemens Tempfer; Inge Schmitz; Andrea Tannapfel; Dirk Strumberg
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IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma
Bowie Y. Cheng; Eunice Y. Lau; Hoi-Wing Leung; Carmen Oi-Ning Leung; Nicole P. Ho; Shilpa Gurung; Lily K. Cheng; Chi Ho Lin; Regina Cheuk-Lam Lo; Stephanie Ma; Irene Oi-Lin Ng; Terence K. Lee
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Expression of Adipocyte/Macrophage Fatty Acid–Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression
Jiaqing Hao; Fei Yan; Yuwen Zhang; Ashley Triplett; Ying Zhang; Debra A. Schultz; Yanwen Sun; Jun Zeng; Kevin A.T. Silverstein; Qi Zheng; David A. Bernlohr; Margot P. Cleary; Nejat K. Egilmez; Edward Sauter; Shujun Liu; Jill Suttles; Bing Li
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FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression
Marten Hornsveld; Lydia M.M. Smits; Maaike Meerlo; Miranda van Amersfoort; Marian J.A. Groot Koerkamp; Dik van Leenen; David E.A. Kloet; Frank C.P. Holstege; Patrick W.B. Derksen; Boudewijn M.T. Burgering; Tobias B. Dansen
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Author Choice
Single-Cell Transcriptome Analyses Reveal Endothelial Cell Heterogeneity in Tumors and Changes following Antiangiogenic Treatment
Qi Zhao; Alexandra Eichten; Asma Parveen; Christina Adler; Ying Huang; Wei Wang; Yueming Ding; Alexander Adler; Thomas Nevins; Min Ni; Yi Wei; Gavin Thurston
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Translational Science

Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
Toni M. Brand; Stefan Hartmann; Neil E. Bhola; Hua Li; Yan Zeng; Rachel A. O'Keefe; Max V. Ranall; Sourav Bandyopadhyay; Margaret Soucheray; Nevan J. Krogan; Carolyn Kemp; Umamaheswar Duvvuri; Theresa LaVallee; Daniel E. Johnson; Michelle A. Ozbun; Julie E. Bauman; Jennifer R. Grandis
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Author Choice
The FACT inhibitor CBL0137 Synergizes with Cisplatin in Small-Cell Lung Cancer by Increasing NOTCH1 Expression and Targeting Tumor-Initiating Cells
Sarmishtha De; Daniel J. Lindner; Claire J. Coleman; Gary Wildey; Afshin Dowlati; George R. Stark
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Author Choice
Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients
Liye He; Jing Tang; Emma I. Andersson; Sanna Timonen; Steffen Koschmieder; Krister Wennerberg; Satu Mustjoki; Tero Aittokallio
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Convergence and Technologies

Combination Therapy and the Evolution of Resistance: The Theoretical Merits of Synergism and Antagonism in Cancer
Elysia C. Saputra; Lu Huang; Yihui Chen; Lisa Tucker-Kellogg
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Population and Prevention Science

Genetic Hitchhiking and Population Bottlenecks Contribute to Prostate Cancer Disparities in Men of African Descent
Joseph Lachance; Ali J. Berens; Matthew E.B. Hansen; Andrew K. Teng; Sarah A. Tishkoff; Timothy R. Rebbeck
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Corrections

Correction: Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
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Correction: SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research
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Correction: Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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