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15 April 2018
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Cover Image
Cover Image
Nuclear active RSK2 (magenta, left) correlates with ERα (blue, right) in sixty percent of ER+ patients as visualized in this serial section from an ER+ tumor. In each section the cells were also stained for cytokeratin 8 (lime, left; magenta, right) and cytokeratin 14 (cyan, left; yellow, right). In the left image, cells that are positive for both K8 and K14 are teal and on the right, these dual-positive cells are orange. Sequestration of RSK2 by ERα in the nucleus drives a pro-neoplastic transcriptional program critical to the ER+ lineage in the mammary gland, neoplasia, and differing patient responses to antiestrogen therapies. For details, see article by Ludwik and colleagues on page 2014. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Editorial
Review
Point–Counterpoint Reviews
Genome and Epigenome
Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier SLC25A11 Gene Confer a Predisposition to Metastatic Paragangliomas
Alexandre Buffet; Aurélie Morin; Luis-Jaime Castro-Vega; Florence Habarou; Charlotte Lussey-Lepoutre; Eric Letouzé; Hervé Lefebvre; Isabelle Guilhem; Magalie Haissaguerre; Isabelle Raingeard; Mathilde Padilla-Girola; Thi Tran; Lucien Tchara; Jérôme Bertherat; Laurence Amar; Chris Ottolenghi; Nelly Burnichon; Anne-Paule Gimenez-Roqueplo; Judith Favier
Metabolism and Chemical Biology
Molecular Cell Biology
Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma
Anja Groß; Catrine Schulz; Jasmine Kolb; Jan Koster; Sibylle Wehner; Sebastian Czaplinski; Abdulghani Khilan; Hermann Rohrer; Patrick N. Harter; Thomas Klingebiel; Julian D. Langer; Dirk Geerts; Dorothea Schulte
Tumor Biology and Immunology
Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells
Tonya C. Walser; Zhe Jing; Linh M. Tran; Ying Q. Lin; Natalie Yakobian; Gerald Wang; Kostyantyn Krysan; Li X. Zhu; Sherven Sharma; Mi-Heon Lee; John A. Belperio; Aik T. Ooi; Brigitte N. Gomperts; Jerry W. Shay; Jill E. Larsen; John D. Minna; Long-sheng Hong; Michael C. Fishbein; Steven M. Dubinett
CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes
Younghun Jung; Frank C. Cackowski; Kenji Yumoto; Ann M. Decker; Jingcheng Wang; Jin Koo Kim; Eunsohl Lee; Yugang Wang; Jae-Seung Chung; Amy M. Gursky; Paul H. Krebsbach; Kenneth J. Pienta; Todd M. Morgan; Russell S. Taichman
Translational Science
Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
Kimberly McClinch; Rita A. Avelar; David Callejas; Sudeh Izadmehr; Danica Wiredja; Abbey Perl; Jaya Sangodkar; David B. Kastrinsky; Daniela Schlatzer; Maxwell Cooper; Janna Kiselar; Agnes Stachnik; Shen Yao; Divya Hoon; Daniel McQuaid; Nilesh Zaware; Yixuan Gong; David L. Brautigan; Stephen R. Plymate; Cynthia C.T. Sprenger; William K. Oh; Alice C. Levine; Alexander Kirschenbaum; John P. Sfakianos; Rosalie Sears; Analisa DiFeo; Yiannis Ioannou; Michael Ohlmeyer; Goutham Narla; Matthew D. Galsky
Author Choice
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Mathieu Unbekandt; Simone Belshaw; Justin Bower; Maeve Clarke; Jacqueline Cordes; Diane Crighton; Daniel R. Croft; Martin J. Drysdale; Mathew J. Garnett; Kathryn Gill; Christopher Gray; David A. Greenhalgh; James A.M. Hall; Jennifer Konczal; Sergio Lilla; Duncan McArthur; Patricia McConnell; Laura McDonald; Lynn McGarry; Heather McKinnon; Carol McMenemy; Mokdad Mezna; Nicolas A. Morrice; June Munro; Gregory Naylor; Nicola Rath; Alexander W. Schüttelkopf; Mairi Sime; Michael F. Olson
Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody–Drug Conjugates
Hui Zhao; John Atkinson; Sara Gulesserian; Zhilan Zeng; Jenny Nater; Jimmy Ou; Peng Yang; Karen Morrison; Jeffrey Coleman; Faisal Malik; Pia Challita-Eid; Sher Karki; Hector Aviña; René Hubert; Linnette Capo; Josh Snyder; Sung-Ju Moon; Roland Luethy; Brian A. Mendelsohn; David R. Stover; Fernando Doñate
Convergence and Technologies
Resource Report
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