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15 March 2018
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Cover Image
Cover Image
Visualization of chromatin disassembly ongoing in tumor cell treated with an anticancer drug candidate curaxin CBL0137. Binding of CBL0137, as well as some other small molecules, to cellular DNA alters DNA helical structure, leading to nucleosome disassembly and loss of histones from chromatin. This is manifested as a shift from sharp to diffuse distribution of H1 histone tagged with mCherry fluorescent protein from the right to the left panel in the top row. This process is dependent on whether small molecules cause or do not cause DNA damage. Histone chaperone FACT binds destabilized nucleosomes in which a shift of the green fluorescence is seen that corresponds with FACT subunit SSRP1 tagged with a green fluorescent protein from the nucleoplasm and the nucleoli to chromatin (middle row, right to left panels). The ability to cause “chromatin damage” correlates better with anticancer potency of small molecules than their DNA damage capability, suggesting that it plays an important role in the anticancer activity of DNA binding small molecules. Bottom, a superposition of images in the two top rows. For details, see article by Nesher and colleagues on page 1431. - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Perspectives
Genome and Epigenome
Genes Predisposed to DNA Hypermethylation during Acquired Resistance to Chemotherapy Are Identified in Ovarian Tumors by Bivalent Chromatin Domains at Initial Diagnosis
Edward Curry; Constanze Zeller; Nahal Masrour; Darren K. Patten; John Gallon; Charlotte S. Wilhelm-Benartzi; Sadaf Ghaem-Maghami; David D. Bowtell; Robert Brown
Metabolism and Chemical Biology
Molecular Cell Biology
Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10
Adrien Nougarede; Nikolay Popgeorgiev; Loay Kassem; Soleilmane Omarjee; Stephane Borel; Ivan Mikaelian; Jonathan Lopez; Rudy Gadet; Olivier Marcillat; Isabelle Treilleux; Bruno O. Villoutreix; Ruth Rimokh; Germain Gillet
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C
Xiaohua Chen; Jun Xian Loo; Xin Shi; Wenjun Xiong; Yong Guo; Haiqiang Ke; Mingkun Yang; Yanping Jiang; Siyu Xia; Min Zhao; Shan Zhong; Chunjiang He; Li Fu; Feng Li
Tumor Biology and Immunology
CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1–Mediated ERK and BCL2/Cyclin D1 Pathways
Shiri Klein; Michal Abraham; Baruch Bulvik; Elia Dery; Ido D. Weiss; Neta Barashi; Rinat Abramovitch; Hanna Wald; Yaniv Harel; Devorah Olam; Lola Weiss; Katia Beider; Orly Eizenberg; Ori Wald; Eithan Galun; Yaron Pereg; Amnon Peled
Translational Science
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Wenlin Shao; Yuji M. Mishina; Yun Feng; Giordano Caponigro; Vesselina G. Cooke; Stacy Rivera; Yingyun Wang; Fang Shen; Joshua M. Korn; Lesley A. Mathews Griner; Gisele Nishiguchi; Alice Rico; John Tellew; Jacob R. Haling; Robert Aversa; Valery Polyakov; Richard Zang; Mohammad Hekmat-Nejad; Payman Amiri; Mallika Singh; Nicholas Keen; Michael P. Dillon; Emma Lees; Savithri Ramurthy; William R. Sellers; Darrin D. Stuart
A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo
Hien Anh Nguyen; Ying Su; Jenny Y. Zhang; Aleksandar Antanasijevic; Michael Caffrey; Amanda M. Schalk; Li Liu; Damiano Rondelli; Annie Oh; Dolores L. Mahmud; Maarten C. Bosland; Andre Kajdacsy-Balla; Sofie Peirs; Tim Lammens; Veerle Mondelaers; Barbara De Moerloose; Steven Goossens; Michael J. Schlicht; Kasim K. Kabirov; Alexander V. Lyubimov; Bradley J. Merrill; Yogen Saunthararajah; Pieter Van Vlierberghe; Arnon Lavie
Convergence and Technologies
Improved Evaluation of Antivascular Cancer Therapy Using Constrained Tracer-Kinetic Modeling for Multiagent Dynamic Contrast-Enhanced MRI
Stefanie J. Hectors; Igor Jacobs; Jasper Lok; Johannes Peters; Johan Bussink; Freek J. Hoeben; Henk M. Keizer; Henk M. Janssen; Klaas Nicolay; Matthias C. Schabel; Gustav J. Strijkers
Letters to the Editor
Correction
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