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1 February 2018
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Cover Image
Cover Image
Membrane-anchored wild-type and mutant Ras form dimers (or nanoclusters). Dimerization (or nanoclustering) is required for Raf's dimerization, activation, and Raf/MEK/ERK (MAPK) signaling (top part of the figure). By contrast, Ras dimerization (nanoclustering) is not required for PI3Kα activation, because PI3Kα essentially acts as a single unit (bottom part of the figure). Wild-type Ras activation of PI3Kα is helped by the phosphorylated C-terminal motif of RTK, which releases the autoinhibition of the p110 subunit by the p85 subunit. In the absence of RTK signaling, phosphorylated calmodulin helps oncogenic KRas. Because only KRas binds calmodulin, only KRas can fully activate PI3Kα/Akt signaling. Full activation of both MAPK and PI3Kα/Akt proliferative pathways by oncogenic KRas4B, but not by HRas or NRas, may help explain why the KRas4B isoform is especially highly populated in certain cancers. For details, see article by Nussinov and colleagues on page 593.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Reviews
Priority Report
Genome and Epigenome
Molecular Cell Biology
Tumor Biology and Immunology
Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation
Joke Tommelein; Elly De Vlieghere; Laurine Verset; Elodie Melsens; Justine Leenders; Benedicte Descamps; Annelies Debucquoy; Christian Vanhove; Patrick Pauwels; Christian P. Gespach; Anne Vral; Astrid De Boeck; Karin Haustermans; Pascal de Tullio; Wim Ceelen; Pieter Demetter; Tom Boterberg; Marc Bracke; Olivier De Wever
Author Choice
Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Yanming Wu; Zhao Zhang; Mauro E. Cenciarini; Cecilia J. Proietti; Matias Amasino; Tao Hong; Mei Yang; Yiji Liao; Huai-Chin Chiang; Virginia G. Kaklamani; Rinath Jeselsohn; Ratna K. Vadlamudi; Tim Hui-Ming Huang; Rong Li; Carmine De Angelis; Xiaoyong Fu; Patricia V. Elizalde; Rachel Schiff; Myles Brown; Kexin Xu
Translational Science
Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer
Jason. P.W. Carey; Cansu Karakas; Tuyen Bui; Xian Chen; Smruthi Vijayaraghavan; Yang Zhao; Jing Wang; Keith Mikule; Jennifer K. Litton; Kelly K. Hunt; Khandan Keyomarsi
Author Choice
Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer
Luz Garcia-Alonso; Francesco Iorio; Angela Matchan; Nuno Fonseca; Patricia Jaaks; Gareth Peat; Miguel Pignatelli; Fiammetta Falcone; Cyril H. Benes; Ian Dunham; Graham Bignell; Simon S. McDade; Mathew J. Garnett; Julio Saez-Rodriguez
Author Choice
CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition
Mayur A. Gadhikar; Jiexin Zhang; Li Shen; Xiayu Rao; Jing Wang; Mei Zhao; Nene N. Kalu; Faye M. Johnson; Lauren A. Byers; John Heymach; Walter N. Hittelman; Durga Udayakumar; Raj K. Pandita; Tej K. Pandita; Curtis R. Pickering; Abena B. Redwood; Helen Piwnica-Worms; Katharina Schlacher; Mitchell J. Frederick; Jeffrey N. Myers
Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery
Krystyna M. Wozniak; James J. Vornov; Ying Wu; Ying Liu; Valentina A. Carozzi; Virginia Rodriguez-Menendez; Elisa Ballarini; Paola Alberti; Eleonora Pozzi; Sara Semperboni; Brett M. Cook; Bruce A. Littlefield; Kenichi Nomoto; Krista Condon; Sean Eckley; Christopher DesJardins; Leslie Wilson; Mary A. Jordan; Stuart C. Feinstein; Guido Cavaletti; Michael Polydefkis; Barbara S. Slusher
Convergence and Technologies
Corrections
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