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Volume 78, Issue 21
1 November 2018
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    A novel screen that allows the quantification of chromosome loss of human artificial chromosomes identified inhibitors of telomerase function that induce a high rate of aneuploidy. Using immunofluorescence, the authors characterized the defects in mitosis induced by the telomerase inhibitors. These include chromatin bridges and ultrafine bridges. For details, see article by Lee and colleagues on page 6282.
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Insights

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target
Damian A. Almiron Bonnin; Matthew C. Havrda; Mark A. Israel
View articletitled, Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target
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Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy
Nurbubu T. Moldogazieva; Sergey V. Lutsenko; Alexander A. Terentiev
View articletitled, Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy
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Author Choice
Zebrafish: Speeding Up the Cancer Drug Discovery Process
Patricia Letrado; Irene de Miguel; Iranzu Lamberto; Roberto Díez-Martínez; Julen Oyarzabal
View articletitled, Zebrafish: Speeding Up the Cancer Drug Discovery Process
Supplementary data
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Metabolism and Chemical Biology

Author Choice
Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape
Cankut Cubuk; Marta R. Hidalgo; Alicia Amadoz; Miguel A. Pujana; Francesca Mateo; Carmen Herranz; Jose Carbonell-Caballero; Joaquin Dopazo
View articletitled, Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape
Supplementary data
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Molecular Cell Biology

HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer
Fei Huang; Qiaoni Shi; Yuzhen Li; Linlin Xu; Chi Xu; Fenfang Chen; Hai Wang; Hongwei Liao; Zai Chang; Fang Liu; Xiang H.-F. Zhang; Xin-Hua Feng; Jing-Dong J. Han; Shiwen Luo; Ye-Guang Chen
View articletitled, HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer
Supplementary data
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Author Choice
Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential
Mariana Reis-Sobreiro; Jie-Fu Chen; Tatiana Novitskaya; Sungyong You; Samantha Morley; Kenneth Steadman; Navjot Kaur Gill; Adel Eskaros; Mirja Rotinen; Chia-Yi Chu; Leland W.K. Chung; Hisashi Tanaka; Wei Yang; Beatrice S. Knudsen; Hsian-Rong Tseng; Amy C. Rowat; Edwin M. Posadas; Andries Zijlstra; Dolores Di Vizio; Michael R. Freeman
View articletitled, Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential
Supplementary data
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Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation
Jooske F. van Lidth de Jeude; Claudia N. Spaan; Bartolomeus J. Meijer; Wouter L. Smit; Tanya T.D. Soeratram; Mattheus C.B. Wielenga; B. Florien Westendorp; Amy S. Lee; Sander Meisner; Jacqueline L.M. Vermeulen; Manon E. Wildenberg; Gijs R. van den Brink; Vanesa Muncan; Jarom Heijmans
View articletitled, Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation
Supplementary data
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p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4
Chihiro Kajiwara; Katsumi Fumoto; Hirokazu Kimura; Satoshi Nojima; Keita Asano; Kazuki Odagiri; Makoto Yamasaki; Hayato Hikita; Tetsuo Takehara; Yuichiro Doki; Eiichi Morii; Akira Kikuchi
View articletitled, p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4
Supplementary data
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Author Choice
A Nonpump Function of Sodium Iodide Symporter in Thyroid Cancer via Cross-talk with PTEN Signaling
Fang Feng; Lamis Yehia; Ying Ni; Yi Seok Chang; Sissy Meihua Jhiang; Charis Eng
View articletitled, A Nonpump Function of Sodium Iodide Symporter in Thyroid Cancer via Cross-talk with PTEN Signaling
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Tumor Biology and Immunology

Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men
Marc Gillard; Rodrigo Javier; Yuan Ji; S. Lilly Zheng; Jianfeng Xu; Charles B. Brendler; Susan E. Crawford; Brandon L. Pierce; Donald J. Vander Griend; Omar E. Franco
View articletitled, Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men
Supplementary data
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Author Choice
Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Supriya Srinivasan; Tulasigeri Totiger; Chanjuan Shi; Jason Castellanos; Purushottam Lamichhane; Austin R. Dosch; Fanuel Messaggio; Nilesh Kashikar; Kumaraswamy Honnenahally; Yuguang Ban; Nipun B. Merchant; Michael VanSaun; Nagaraj S. Nagathihalli
View articletitled, Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Supplementary data
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Author Choice
Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer
Sri Krishna; Peaches Ulrich; Eric Wilson; Falguni Parikh; Pooja Narang; Shanshan Yang; Amelia K. Read; Seunghee Kim-Schulze; Jin G. Park; Marshall Posner; Melissa A. Wilson Sayres; Andrew Sikora; Karen S. Anderson
View articletitled, Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8<sup>+</sup> T Cells in Head and Neck Cancer
Supplementary data
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Intrathecal Viral Vector Delivery of Trastuzumab Prevents or Inhibits Tumor Growth of Human HER2-Positive Xenografts in Mice
William T. Rothwell; Peter Bell; Laura K. Richman; Maria P. Limberis; Anna P. Tretiakova; Mingyao Li; James M. Wilson
View articletitled, Intrathecal Viral Vector Delivery of Trastuzumab Prevents or Inhibits Tumor Growth of Human HER2-Positive Xenografts in Mice
Supplementary data
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Author Choice
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers
David L. Elion; Max E. Jacobson; Donna J. Hicks; Bushra Rahman; Violeta Sanchez; Paula I. Gonzales-Ericsson; Olga Fedorova; Anna M. Pyle; John T. Wilson; Rebecca S. Cook
View articletitled, Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers
Supplementary data
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HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress
Brandt A. Nichols; Nathaniel W. Oswald; Elizabeth A. McMillan; Kathleen McGlynn; Jingsheng Yan; Min S. Kim; Janapriya Saha; Prema L. Mallipeddi; Sydnie A. LaDuke; Pamela A. Villalobos; Jaime Rodriguez-Canales; Ignacio I. Wistuba; Bruce A. Posner; Anthony J. Davis; John D. Minna; John B. MacMillan; Angelique W. Whitehurst
View articletitled, HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress
Supplementary data
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Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures
Nilgun Tasdemir; Emily A. Bossart; Zheqi Li; Li Zhu; Matthew J. Sikora; Kevin M. Levine; Britta M. Jacobsen; George C. Tseng; Nancy E. Davidson; Steffi Oesterreich
View articletitled, Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures
Supplementary data
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Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia
Sabrina Inselmann; Ying Wang; Susanne Saussele; Lea Fritz; Christin Schütz; Magdalena Huber; Simone Liebler; Thomas Ernst; Dali Cai; Sarah Botschek; Cornelia Brendel; Raffaele A. Calogero; Dinko Pavlinic; Vladimir Benes; Edison T. Liu; Andreas Neubauer; Andreas Hochhaus; Andreas Burchert
View articletitled, Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia
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Translational Science

Author Choice
Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
Nagaraj S. Nagathihalli; Jason A. Castellanos; Purushottam Lamichhane; Fanuel Messaggio; Chanjuan Shi; Xizi Dai; Priyamvada Rai; Xi Chen; Michael N. VanSaun; Nipun B. Merchant
View articletitled, Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
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Author Choice
CD44-Targeting PLGA Nanoparticles Incorporating Paclitaxel and FAK siRNA Overcome Chemoresistance in Epithelial Ovarian Cancer
Yeongseon Byeon; Jeong-Won Lee; Whan Soo Choi; Ji Eun Won; Ga Hee Kim; Min Gi Kim; Tae In Wi; Jae Myeong Lee; Tae Heung Kang; In Duk Jung; Young-Jae Cho; Hyung Jun Ahn; Byung Cheol Shin; Young Joo Lee; Anil K. Sood; Hee Dong Han; Yeong-Min Park
View articletitled, CD44-Targeting PLGA Nanoparticles Incorporating Paclitaxel and FAK siRNA Overcome Chemoresistance in Epithelial Ovarian Cancer
Supplementary data
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Author Choice
Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201
Sébastien Jeay; Stéphane Ferretti; Philipp Holzer; Jeanette Fuchs; Emilie A. Chapeau; Markus Wartmann; Dario Sterker; Vincent Romanet; Masato Murakami; Grainne Kerr; Eric Y. Durand; Swann Gaulis; Marta Cortes-Cros; Stephan Ruetz; Therese-Marie Stachyra; Joerg Kallen; Pascal Furet; Jens Würthner; Nelson Guerreiro; Ensar Halilovic; Astrid Jullion; Audrey Kauffmann; Emil Kuriakose; Marion Wiesmann; Michael R. Jensen; Francesco Hofmann; William R. Sellers
View articletitled, Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201
Supplementary data
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Author Choice
Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG24-DFO[89Zr] for Tumor-Specific PET/CT Imaging
Stefan Stangl; Lorenzo Tei; Francesco De Rose; Sybille Reder; Jonathan Martinelli; Wolfgang Sievert; Maxim Shevtsov; Rupert Öllinger; Roland Rad; Markus Schwaiger; Calogero D'Alessandria; Gabriele Multhoff
View articletitled, Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG<sub>24</sub>-DFO[<sup>89</sup>Zr] for Tumor-Specific PET/CT Imaging
Supplementary data
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Author Choice
Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy
Hee-Sheung Lee; Mar Carmena; Mikhail Liskovykh; Emma Peat; Jung-Hyun Kim; Mitsuo Oshimura; Hiroshi Masumoto; Marie-Paule Teulade-Fichou; Yves Pommier; William C. Earnshaw; Vladimir Larionov; Natalay Kouprina
View articletitled, Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy
Supplementary data
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RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma
Thomas F. Eleveld; Linda Schild; Jan Koster; Danny A. Zwijnenburg; Lindy K. Alles; Marli E. Ebus; Richard Volckmann; Godelieve A. Tijtgat; Peter van Sluis; Rogier Versteeg; Jan J. Molenaar
View articletitled, RAS–MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma
Supplementary data
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Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma
Jason R. Baird; R. Bryan Bell; Victoria Troesch; David Friedman; Shelly Bambina; Gwen Kramer; Tiffany C. Blair; Terry Medler; Yaping Wu; Zhaoyu Sun; Tanja D. de Gruijl; Rieneke van de Ven; Rom S. Leidner; Marka R. Crittenden; Michael J. Gough
View articletitled, Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma
Supplementary data
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Convergence and Technologies

Author Choice
CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
Ana R. Cortazar; Veronica Torrano; Natalia Martín-Martín; Alfredo Caro-Maldonado; Laura Camacho; Ivana Hermanova; Elizabeth Guruceaga; Luis F. Lorenzo-Martín; Ruben Caloto; Roger R. Gomis; Iñigo Apaolaza; Victor Quesada; Jan Trka; Antonio Gomez-Muñoz; Silvestre Vincent; Xose R. Bustelo; Francisco J. Planes; Ana M. Aransay; Arkaitz Carracedo
View articletitled, CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets
Supplementary data
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Population and Prevention Science

Author Choice
Differential Burden of Rare and Common Variants on Tumor Characteristics, Survival, and Mode of Detection in Breast Cancer
Jingmei Li; Emilio Ugalde-Morales; Wei Xiong Wen; Brennan Decker; Mikael Eriksson; Astrid Torstensson; Helene Nordahl Christensen; Alison M. Dunning; Jamie Allen; Craig Luccarini; Karen A. Pooley; Jacques Simard; Leila Dorling; Douglas F. Easton; Soo Hwang Teo; Per Hall; Kamila Czene
View articletitled, Differential Burden of Rare and Common Variants on Tumor Characteristics, Survival, and Mode of Detection in Breast Cancer
Supplementary data
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Letters to the Editor

JAM-C Expression as a Biomarker to Predict Outcome of Patients with Acute Myeloid Leukemia—Letter
Malte von Bonin; Katharina Moll; Michael Kramer; Uta Oelschlägel; Martin Wermke; Christoph Röllig; Christian Thiede; Gerhard Ehninger; Alwin Krämer; Carsten Müller-Tidow; Ioannis Mitroulis; Martin Bornhäuser
View articletitled, JAM-C Expression as a Biomarker to Predict Outcome of Patients with Acute Myeloid Leukemia—Letter
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JAM-C Expression as a Biomarker to Predict Outcome of Patients with Acute Myeloid Leukemia—Response
Maria De Grandis; Stéphane J.C. Mancini; Norbert Vey; Michel Aurrand-Lions
View articletitled, JAM-C Expression as a Biomarker to Predict Outcome of Patients with Acute Myeloid Leukemia—Response
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Correction

Correction: MUC1 Oncoprotein Promotes Refractoriness to Chemotherapy in Thyroid Cancer Cells
View articletitled, Correction: MUC1 Oncoprotein Promotes Refractoriness to Chemotherapy in Thyroid Cancer Cells
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Retractions

Retraction: Inactivation of the Quinone Oxidoreductases NQO1 and NQO2 Strongly Elevates the Incidence and Multiplicity of Chemically Induced Skin Tumors
Jun Shen; Roberto J. Barrios; Anil K. Jaiswal
View articletitled, Retraction: Inactivation of the Quinone Oxidoreductases NQO1 and NQO2 Strongly Elevates the Incidence and Multiplicity of Chemically Induced Skin Tumors
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Retraction: Low and High Dose UVB Regulation of Transcription Factor NF-E2-Related Factor 2
Sankaranarayanan Kannan; Anil K. Jaiswal
View articletitled, Retraction: Low and High Dose UVB Regulation of Transcription Factor NF-E2-Related Factor 2
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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