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Volume 78, Issue 18
15 September 2018
Cancer Research Cover Image for Volume 78, Issue 18
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  • Cover Image

    Cover Image

    Issue cover image
    Human breast cancer tissue stained by immunofluorescence illustrates the interplay between secreted and surface-bound TGFβ (red) expressed by cancer cells (blue), which primes tumor-infiltrating myeloid cells to produce IL1β (green). This in turn will lead to chronic inflammation associated with breast cancer progression. Gray, nuclei. For details, see article by Wu and colleagues on page 5243.
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Insights

Highlights from Recent Cancer Literature
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Review

Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy
David H. Munn; Madhav D. Sharma; Theodore S. Johnson
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Cancer Research Highlights

An Interleukin-1 Signature in Breast Cancer Treated with Interleukin-1 Receptor Blockade: Implications for Treating Cytokine Release Syndrome of Checkpoint Inhibitors
Charles Anthony Dinarello
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Molecular Cell Biology

BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer
Sen Chen; Changmeng Cai; Adam G. Sowalsky; Huihui Ye; Fen Ma; Xin Yuan; Nicholas I. Simon; Nathanael S. Gray; Steven P. Balk
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ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer
Yujun Li; Qi Yang; Haixia Guan; Bingyin Shi; Meiju Ji; Peng Hou
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Tumor Biology and Immunology

Featured Image
Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells
Eloise M. Grasset; Thomas Bertero; Alexandre Bozec; Jonas Friard; Isabelle Bourget; Sabrina Pisano; Margaux Lecacheur; Majdi Maiel; Caroline Bailleux; Alexander Emelyanov; Marius Ilie; Paul Hofman; Guerrino Meneguzzi; Christophe Duranton; Dmitry V. Bulavin; Cedric Gaggioli
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Author Choice
IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer
Te-Chia Wu; Kangling Xu; Jan Martinek; Robyn R. Young; Romain Banchereau; Joshy George; Jacob Turner; Kyung In Kim; Sandra Zurawski; Xuan Wang; Derek Blankenship; Hannah M. Brookes; Florentina Marches; Gerlinde Obermoser; Elizabeth Lavecchio; Maren K. Levin; Sookyoung Bae; Cheng-Han Chung; Jennifer L. Smith; Alma-Martina Cepika; Kyp L. Oxley; George J. Snipes; Jacques Banchereau; Virginia Pascual; Joyce O'Shaughnessy; A. Karolina Palucka
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miRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis–Associated Genes
Martine Croset; Francesco Pantano; Casina W.S. Kan; Edith Bonnelye; Françoise Descotes; Catherine Alix-Panabières; Charles-Henri Lecellier; Richard Bachelier; Nathalie Allioli; Saw-See Hong; Kai Bartkowiak; Klaus Pantel; Philippe Clézardin
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FBXO22 Possesses Both Protumorigenic and Antimetastatic Roles in Breast Cancer Progression
Rui Sun; Hong-Yan Xie; Jin-Xian Qian; Yan-Ni Huang; Fan Yang; Fang-Lin Zhang; Zhi-Min Shao; Da-Qiang Li
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Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma
Yoav Binenbaum; Eran Fridman; Zvi Yaari; Neta Milman; Avi Schroeder; Gil Ben David; Tomer Shlomi; Ziv Gil
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Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer
Jessalyn M. Ubellacker; Ninib Baryawno; Nicolas Severe; Molly J. DeCristo; Jaclyn Sceneay; John N. Hutchinson; Marie-Therese Haider; Catherine S. Rhee; Yuanbo Qin; Walter M. Gregory; Ana C. Garrido-Castro; Ingunn Holen; Janet E. Brown; Robert E. Coleman; David T. Scadden; Sandra S. McAllister
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Activation of NKT Cells in an Anti-PD-1–Resistant Tumor Model Enhances Antitumor Immunity by Reinvigorating Exhausted CD8 T Cells
Eun-Ah Bae; Hyungseok Seo; Byung-Seok Kim; Jeongwon Choi; Insu Jeon; Kwang-Soo Shin; Choong-Hyun Koh; Boyeong Song; Il-Kyu Kim; Byung Soh Min; Yoon Dae Han; Sang Joon Shin; Chang-Yuil Kang
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Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers
Stephanie Dorta-Estremera; Renee L. Chin; Gloria Sierra; Courtney Nicholas; Ananta V. Yanamandra; Sita M.K. Nookala; Guojun Yang; Shail Singh; Michael A. Curran; K. Jagannadha Sastry
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Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer
Daniel O. Villarreal; Andrew L'Huillier; Susan Armington; Cristina Mottershead; Elena V. Filippova; Brandon D. Coder; Robert G. Petit; Michael F. Princiotta
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Translational Science

Featured Image
Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow–Resident Melanoma CTCs
Monika Vishnoi; Debasish Boral; Haowen Liu; Marc L. Sprouse; Wei Yin; Debalina Goswami-Sewell; Michael T. Tetzlaff; Michael A. Davies; Isabella C. Glitza Oliva; Dario Marchetti
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Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes
Hai Dang Nguyen; Wan Yee Leong; Weiling Li; Pavankumar N.G. Reddy; Jack D. Sullivan; Matthew J. Walter; Lee Zou; Timothy A. Graubert
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Mouse Homolog of the Human TP53 R337H Mutation Reveals Its Role in Tumorigenesis
Ji-Hoon Park; Jie Li; Matthew F. Starost; Chengyu Liu; Jie Zhuang; Jichun Chen; Maria I. Achatz; Ju-Gyeong Kang; Ping-yuan Wang; Sharon A. Savage; Paul M. Hwang
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mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells
Tra-Ly Nguyen; Marie-Julie Nokin; Maxim Egorov; Mercedes Tomé; Clément Bodineau; Carmelo Di Primo; Lætitia Minder; Joanna Wdzieczak-Bakala; Maria Concepcion Garcia-Alvarez; Jérôme Bignon; Odile Thoison; Bernard Delpech; Georgiana Surpateanu; Yves-Michel Frapart; Fabienne Peyrot; Kahina Abbas; Silvia Terés; Serge Evrard; Abdel-Majid Khatib; Pierre Soubeyran; Bogdan I. Iorga; Raúl V. Durán; Pascal Collin
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Phase Ib Results of the Rational Combination of Selumetinib and Cyclosporin A in Advanced Solid Tumors with an Expansion Cohort in Metastatic Colorectal Cancer
Anuradha Krishnamurthy; Arvind Dasari; Anne M. Noonan; Janice M. Mehnert; Albert C. Lockhart; Stephen Leong; Anna Capasso; Mark N. Stein; Hanna K. Sanoff; James J. Lee; Aaron Hansen; Usha Malhotra; Sarah Rippke; Daniel L. Gustafson; Todd M. Pitts; Kim Ellison; S. Lindsey Davis; Wells A. Messersmith; S. Gail Eckhardt; Christopher H. Lieu
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Author Choice
Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma
Richard Mair; Alan J. Wright; Susana Ros; De-en Hu; Tom Booth; Felix Kreis; Jyotsna Rao; Colin Watts; Kevin M. Brindle
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A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk
Yingchang Lu; Alicia Beeghly-Fadiel; Lang Wu; Xingyi Guo; Bingshan Li; Joellen M. Schildkraut; Hae Kyung Im; Yian A. Chen; Jennifer B. Permuth; Brett M. Reid; Jamie K. Teer; Kirsten B. Moysich; Irene L. Andrulis; Hoda Anton-Culver; Banu K. Arun; Elisa V. Bandera; Rosa B. Barkardottir; Daniel R. Barnes; Javier Benitez; Line Bjorge; James Brenton; Ralf Butzow; Trinidad Caldes; Maria A. Caligo; Ian Campbell; Jenny Chang-Claude; Kathleen B.M. Claes; Fergus J. Couch; Daniel W. Cramer; Mary B. Daly; Anna deFazio; Joe Dennis; Orland Diez; Susan M. Domchek; Thilo Dörk; Douglas F. Easton; Diana M. Eccles; Peter A. Fasching; Renée T. Fortner; George Fountzilas; Eitan Friedman; Patricia A. Ganz; Judy Garber; Graham G. Giles; Andrew K. Godwin; David E. Goldgar; Marc T. Goodman; Mark H. Greene; Jacek Gronwald; Ute Hamann; Florian Heitz; Michelle A.T. Hildebrandt; Claus K. Høgdall; Antoinette Hollestelle; Peter J. Hulick; David G. Huntsman; Evgeny N. Imyanitov; Claudine Isaacs; Anna Jakubowska; Paul James; Beth Y. Karlan; Linda E. Kelemen; Lambertus A. Kiemeney; Susanne K. Kjaer; Ava Kwong; Nhu D. Le; Goska Leslie; Fabienne Lesueur; Douglas A. Levine; Amalia Mattiello; Taymaa May; Lesley McGuffog; Iain A. McNeish; Melissa A. Merritt; Francesmary Modugno; Marco Montagna; Susan L. Neuhausen; Heli Nevanlinna; Finn C. Nielsen; Liene Nikitina-Zake; Robert L. Nussbaum; Kenneth Offit; Edith Olah; Olufunmilayo I. Olopade; Sara H. Olson; Håkan Olsson; Ana Osorio; Sue K. Park; Michael T. Parsons; Petra H.M. Peeters; Tanja Pejovic; Paolo Peterlongo; Catherine M. Phelan; Miquel Angel Pujana; Susan J. Ramus; Gad Rennert; Harvey Risch; Gustavo C. Rodriguez; Cristina Rodríguez-Antona; Isabelle Romieu; Matti A. Rookus; Mary Anne Rossing; Iwona K. Rzepecka; Dale P. Sandler; Rita K. Schmutzler; Veronica W. Setiawan; Priyanka Sharma; Weiva Sieh; Jacques Simard; Christian F. Singer; Honglin Song; Melissa C. Southey; Amanda B. Spurdle; Rebecca Sutphen; Anthony J. Swerdlow; Manuel R. Teixeira; Soo H. Teo; Mads Thomassen; Marc Tischkowitz; Amanda E. Toland; Antonia Trichopoulou; Nadine Tung; Shelley S. Tworoger; Elizabeth J. van Rensburg; Adriaan Vanderstichele; Ana Vega; Digna Velez Edwards; Penelope M. Webb; Jeffrey N. Weitzel; Nicolas Wentzensen; Emily White; Alicja Wolk; Anna H. Wu; Drakoulis Yannoukakos; Kristin K. Zorn; Simon A. Gayther; Antonis C. Antoniou; Andrew Berchuck; Ellen L. Goode; Georgia Chenevix-Trench; Thomas A. Sellers; Paul D.P. Pharoah; Wei Zheng; Jirong Long
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Convergence and Technologies

A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis
Ming Huang; Tianyu F. Qi; Lin Li; Gao Zhang; Yinsheng Wang
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Network Propagation Predicts Drug Synergy in Cancers
Hongyang Li; Tingyang Li; Daniel Quang; Yuanfang Guan
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Population and Prevention Science

Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia
Signe Holst Søegaard; Klaus Rostgaard; Kristin Skogstrand; Joseph Leo Wiemels; Kjeld Schmiegelow; Henrik Hjalgrim
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Correction

Correction: Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
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Editor’s Note

Editor's Note: In vitro and In vivo Molecular Evidence for Better Therapeutic Efficacy of ABT-627 and Taxotere Combination in Prostate Cancer
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Retractions

Retraction: Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF
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Retraction: 3,3′-Diindolylmethane Enhances Chemosensitivity of Multiple Chemotherapeutic Agents in Pancreatic Cancer
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Retraction: Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer
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Retraction: Down-regulation of Platelet-Derived Growth Factor-D Inhibits Cell Growth and Angiogenesis through Inactivation of Notch-1 and Nuclear Factor-κB Signaling
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Retraction: Down-regulation of Forkhead Box M1 Transcription Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cancer Cells
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Retraction: Inhibition of Angiogenesis and Invasion by 3,3′-Diindolylmethane Is Mediated by the Nuclear Factor–κB Downstream Target Genes MMP-9 and uPA that Regulated Bioavailability of Vascular Endothelial Growth Factor in Prostate Cancer
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Retraction: Potentiation of the Effect of Erlotinib by Genistein in Pancreatic Cancer: The Role of Akt and Nuclear Factor-κB
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Retraction: Down-regulation of Androgen Receptor by 3,3′-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Both Hormone-Sensitive LNCaP and Insensitive C4-2B Prostate Cancer Cells
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Retraction: Epidermal Growth Factor Receptor–Related Protein Inhibits Cell Growth and Invasion in Pancreatic Cancer
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Retraction: Antitumor and Antimetastatic Activities of Docetaxel Are Enhanced by Genistein through Regulation of Osteoprotegerin/Receptor Activator of Nuclear Factor-κB (RANK)/RANK Ligand/MMP-9 Signaling in Prostate Cancer
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Retraction: Down-regulation of Notch-1 Inhibits Invasion by Inactivation of Nuclear Factor-κB, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in Pancreatic Cancer Cells
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Retraction: Antitumor Activity of Epidermal Growth Factor Receptor—Related Protein Is Mediated by Inactivation of ErbB Receptors and Nuclear Factor-κB in Pancreatic Cancer
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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