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1 September 2018
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As the most important sensors on cell membrane, G protein-coupled receptors play nonredundant roles in maintaining tumor microenvironment. LGR4, a leucine-rich repeat-containing G-protein coupled receptor, was identified as a novel immune suppressor involved in promoting M2 polarization of tumor-associated macrophages (TAM), which restricts CD8+ T-cell–mediated antitumor immune responses. Blockade of LGR4/R-spondin signaling pathway retrieves TAM-mediated immunosuppressive tumor microenvironment, which overcomes resistance of lung cancer and melanoma to the anti-PD-1 therapy, indicating vital roles of Rspo-Lgr4 in host antitumor immunity and a potential therapeutic target in cancer immunotherapy. For details, see article by Tan and colleagues on page 4929.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Review
Perspective
Genome and Epigenome
Metabolism and Chemical Biology
Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer
Young Kyuen Im; Ouafa Najyb; Simon-Pierre Gravel; Shawn McGuirk; Ryuhjin Ahn; Daina Z. Avizonis; Valérie Chénard; Valerie Sabourin; Jesse Hudson; Tony Pawson; Ivan Topisirovic; Michael Pollak; Julie St-Pierre; Josie Ursini-Siegel
Molecular Cell Biology
Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer
Payton D. Stevens; Yang-An Wen; Xiaopeng Xiong; Yekaterina Y. Zaytseva; Austin T. Li; Chi Wang; Ashley T. Stevens; Trevor N. Farmer; Tong Gan; Heidi L. Weiss; Masaki Inagaki; Sylvie Marchetto; Jean-Paul Borg; Tianyan Gao
Author Choice
Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression
Jian-Ping He; Pei-Pei Hou; Qi-Tao Chen; Wei-Jia Wang; Xiao-Yu Sun; Peng-Bo Yang; Ying-Ping Li; Lu-Ming Yao; Xiaotong Li; Xin-Dong Jiang; Kun-Yi Chien; Zhi-Ming Zhang; Qiu-Wan Wu; Allison J. Cowin; Qiao Wu; Hang-Zi Chen
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production
Lindsay N. Sausville; Mahesha H. Gangadhariah; Manuel Chiusa; Shaojun Mei; Shouzuo Wei; Roy Zent; James M. Luther; Megan M. Shuey; Jorge H. Capdevila; John R. Falck; F. Peter Guengerich; Scott M. Williams; Ambra Pozzi
SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium
Ansu O. Perekatt; Pooja P. Shah; Shannon Cheung; Nidhi Jariwala; Alex Wu; Vishal Gandhi; Namit Kumar; Qiang Feng; Neeket Patel; Lei Chen; Shilpy Joshi; Anbo Zhou; M. Mark Taketo; Jinchuan Xing; Eileen White; Nan Gao; Michael L. Gatza; Michael P. Verzi
Tumor Biology and Immunology
Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy
Teresa Cejalvo; Ana Judith Perisé-Barrios; Isabel del Portillo; Eduardo Laborda; Miguel A. Rodriguez-Milla; Isabel Cubillo; Fernando Vázquez; David Sardón; Manuel Ramirez; Ramon Alemany; Noemí del Castillo; Javier García-Castro
CTGF Mediates Tumor–Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression
Yuki Makino; Hayato Hikita; Takahiro Kodama; Minoru Shigekawa; Ryoko Yamada; Ryotaro Sakamori; Hidetoshi Eguchi; Eiichi Morii; Hideki Yokoi; Masashi Mukoyama; Suemizu Hiroshi; Tomohide Tatsumi; Tetsuo Takehara
IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Tatiana A. Karakasheva; Eric W. Lin; Qiaosi Tang; Edmund Qiao; Todd J. Waldron; Monica Soni; Andres J. Klein-Szanto; Varun Sahu; Devraj Basu; Shinya Ohashi; Kiichiro Baba; Zachary T. Giaccone; Sarah R. Walker; David A. Frank; E. Paul Wileyto; Qi Long; Margaret C. Dunagin; Arjun Raj; J. Alan Diehl; K.K. Wong; Adam J. Bass; Anil K. Rustgi
Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia
Daniel T. Merrick; Michael G. Edwards; Wilbur A. Franklin; Michio Sugita; Robert L. Keith; York E. Miller; Micah B. Friedman; Lori D. Dwyer-Nield; Meredith A. Tennis; Mary C. O'Keefe; Elizabeth J. Donald; Jessica M. Malloy; Adrie van Bokhoven; Storey Wilson; Peter J. Koch; Charlene O'Shea; Christopher Coldren; David J. Orlicky; Xian Lu; Anna E. Baron; Greg Hickey; Timothy C. Kennedy; Roger Powell; Lynn Heasley; Paul A. Bunn; Mark Geraci; Raphael A. Nemenoff
Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting
Phyllis F. Cheung; Florian Neff; Christian Neander; Anna Bazarna; Konstantinos Savvatakis; Sven-Thorsten Liffers; Kristina Althoff; Chang-Lung Lee; Everett J. Moding; David G Kirsch; Dieter Saur; Alexandr V. Bazhin; Marija Trajkovic-Arsic; Mathias F. Heikenwalder; Jens T. Siveke
Author Choice
Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment
Hirotake Tsukamoto; Koji Fujieda; Azusa Miyashita; Satoshi Fukushima; Tokunori Ikeda; Yosuke Kubo; Satoru Senju; Hironobu Ihn; Yasuharu Nishimura; Hiroyuki Oshiumi
Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma
Maleeha A. Qazi; Parvez Vora; Chitra Venugopal; Jarrett Adams; Mohini Singh; Amy Hu; Maryna Gorelik; Minomi K. Subapanditha; Neil Savage; Jiahe Yang; Chirayu Chokshi; Max London; Alexander Gont; David Bobrowski; Natalie Grinshtein; Kevin R. Brown; Naresh K. Murty; Johan Nilvebrant; David Kaplan; Jason Moffat; Sachdev Sidhu; Sheila K. Singh
Author Choice
Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells
Ross D. Carruthers; Shafiq U. Ahmed; Shaliny Ramachandran; Karen Strathdee; Kathreena M. Kurian; Ann Hedley; Natividad Gomez-Roman; Gabriela Kalna; Mathew Neilson; Lesley Gilmour; Katrina H. Stevenson; Ester M. Hammond; Anthony J. Chalmers
Translational Science
Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade
Brijesh Kumar; Mayuri Prasad; Poornima Bhat-Nakshatri; Manjushree Anjanappa; Maitri Kalra; Natascia Marino; Anna Maria Storniolo; Xi Rao; Sheng Liu; Jun Wan; Yunlong Liu; Harikrishna Nakshatri
Convergence and Technologies
Author Choice
Identification of Metastatic Lymph Nodes in MR Imaging with Faster Region-Based Convolutional Neural Networks
Yun Lu; Qiyue Yu; Yuanxiang Gao; Yunpeng Zhou; Guangwei Liu; Qian Dong; Jinlong Ma; Lei Ding; Hongwei Yao; Zhongtao Zhang; Gang Xiao; Qi An; Guiying Wang; Jinchuan Xi; Weitang Yuan; Yugui Lian; Dianliang Zhang; Chunbo Zhao; Qin Yao; Wei Liu; Xiaoming Zhou; Shuhao Liu; Qingyao Wu; Wenjian Xu; Jianli Zhang; Dongshen Wang; Zhenqing Sun; Yuan Gao; Xianxiang Zhang; Jilin Hu; Maoshen Zhang; Guanrong Wang; Xuefeng Zheng; Lei Wang; Jie Zhao; Shujian Yang
Determination of Tumor Margins with Surgical Specimen Mapping Using Near-Infrared Fluorescence
Rebecca W. Gao; Nutte T. Teraphongphom; Nynke S. van den Berg; Brock A. Martin; Nicholas J. Oberhelman; Vasu Divi; Michael J. Kaplan; Steven S. Hong; Guolan Lu; Robert Ertsey; Willemieke S.F.J. Tummers; Adam J. Gomez; F. Christopher Holsinger; Christina S. Kong; Alexander D. Colevas; Jason M. Warram; Eben L. Rosenthal
Author Choice
High-Throughput Screening of Combinatorial Immunotherapies with Patient-Specific In Silico Models of Metastatic Colorectal Cancer
Jakob Nikolas Kather; Pornpimol Charoentong; Meggy Suarez-Carmona; Esther Herpel; Fee Klupp; Alexis Ulrich; Martin Schneider; Inka Zoernig; Tom Luedde; Dirk Jaeger; Jan Poleszczuk; Niels Halama
Population and Prevention Science
A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer
Jiang Chang; Jianbo Tian; Yang Yang; Rong Zhong; Jiaoyuan Li; Kan Zhai; Juntao Ke; Jiao Lou; Wei Chen; Beibei Zhu; Na Shen; Yi Zhang; Yajie Gong; Ying Zhu; Danyi Zou; Xiating Peng; Kun Huang; Xiaoping Miao
Letters to the Editor
Publisher’s Note
Corrections
Editor’s Notes
Retractions
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