ZIKV^BR displays strong and specific oncolytic property against human central nervous system (CNS) embryonal tumors. Tumor cells infected with the virus (red) are readily destroyed and are ineffective in producing new functional viral particles. In tumor-bearing mice, ZIKV^BR induces significant CNS tumor remission and spinal cord metastasis inhibition. Neural stem-like cancer cells with high Wnt/β-catenin basal activity are more susceptible to the oncolytic effects of ZIKV^BR. For details, see article by Kaid and colleagues on page 3363.