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1 January 2018
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Cover Image
Cover Image
Kinases are master regulators of cell signaling networks that are frequently dysregulated in cancer, and members of the kinome family have been successfully targeted for therapeutic benefit. In this figure, the activity, cellular requirement, disease association, availability of protein structures and drugs, and research publications associated with each of the 535 members of the human protein kinome are displayed. It highlights how most research attention has been focused on relatively small subsets of the kinome. In the associated resource-based review, the authors discuss their current understanding of the human protein kinome, highlight emerging and overlooked areas, and describe key aspects of kinase signaling biology and some of the challenges associated with treating perturbed kinase networks in patients. For details, see article by Wilson and colleagues on page 15.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Insights
Editorial
Obituary
Reviews
Metabolism and Chemical Biology
Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Matthew S. Waitkus; Christopher J. Pirozzi; Casey J. Moure; Bill H. Diplas; Landon J. Hansen; Austin B. Carpenter; Rui Yang; Zhaohui Wang; Brian O. Ingram; Edward D. Karoly; Robert P. Mohney; Ivan Spasojevic; Roger E. McLendon; Henry S. Friedman; Yiping He; Darell D. Bigner; Hai Yan
Molecular Cell Biology
MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels
Yunqi Lu; Zhongyi Hu; Lingegowda S. Mangala; Zachary E. Stine; Xiaowen Hu; Dahai Jiang; Yan Xiang; Youyou Zhang; Sunila Pradeep; Cristian Rodriguez-Aguayo; Gabriel Lopez-Berestein; Angelo M. DeMarzo; Anil K. Sood; Lin Zhang; Chi V. Dang
Author Choice
TGFβ Promotes Genomic Instability after Loss of RUNX3
Vaidehi Krishnan; Yu Lin Chong; Tuan Zea Tan; Madhura Kulkarni; Muhammad Bakhait Bin Rahmat; Lavina Sierra Tay; Haresh Sankar; Doorgesh S. Jokhun; Amudha Ganesan; Linda Shyue Huey Chuang; Dominic C. Voon; GV Shivashankar; Jean-Paul Thiery; Yoshiaki Ito
Tumor Biology and Immunology
An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis
Kimita Suyama; Jiahong Yao; Huizhi Liang; Outhiriaradjou Benard; Olivier D. Loudig; Dulguun Amgalan; Wendy M. McKimpson; Greg R. Phillips; Jeffrey Segall; Yihong Wang; Susan Fineberg; Larry Norton; Richard N. Kitsis; Rachel B. Hazan
CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells
Fernando P. Canale; María C. Ramello; Nicolás Núñez; Cintia L. Araujo Furlan; Sabrina N. Bossio; Melisa Gorosito Serrán; Jimena Tosello Boari; Andrés del Castillo; Marta Ledesma; Christine Sedlik; Eliane Piaggio; Adriana Gruppi; Eva V. Acosta Rodríguez; Carolina L. Montes
A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow
Stephanie Rossnagl; Hiba Ghura; Christopher Groth; Eva Altrock; Franz Jakob; Sarah Schott; Pauline Wimberger; Theresa Link; Jan Dominik Kuhlmann; Arnulf Stenzl; Jörg Hennenlotter; Tilmann Todenhöfer; Markus Rojewski; Karen Bieback; Inaam A. Nakchbandi
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression
Jeff W. Kwak; Jennifer Laskowski; Howard Y. Li; Maria V. McSharry; Trisha R. Sippel; Bonnie L. Bullock; Amber M. Johnson; Joanna M. Poczobutt; Alexander J. Neuwelt; Stephen P. Malkoski; Mary C. Weiser-Evans; John D. Lambris; Eric T. Clambey; Joshua M. Thurman; Raphael A. Nemenoff
Author Choice
Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer
Kathleen F. Ludwig; Wenting Du; Noah B. Sorrelle; Katarzyna Wnuk-Lipinska; Mary Topalovski; Jason E. Toombs; Victoria H. Cruz; Shinichi Yabuuchi; N.V. Rajeshkumar; Anirban Maitra; James B. Lorens; Rolf A. Brekken
Translational Science
Author Choice
Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma
Elizabeth A. Reap; Carter M. Suryadevara; Kristen A. Batich; Luis Sanchez-Perez; Gary E. Archer; Robert J. Schmittling; Pamela K. Norberg; James E. Herndon, II; Patrick Healy; Kendra L. Congdon; Patrick C. Gedeon; Olivia C. Campbell; Adam M. Swartz; Katherine A. Riccione; John S. Yi; Mohammed K. Hossain-Ibrahim; Anirudh Saraswathula; Smita K. Nair; Anastasie M. Dunn-Pirio; Taylor M. Broome; Kent J. Weinhold; Annick Desjardins; Gordana Vlahovic; Roger E. McLendon; Allan H. Friedman; Henry S. Friedman; Darell D. Bigner; Peter E. Fecci; Duane A. Mitchell; John H. Sampson
Rapid Intraoperative Diagnosis of Pediatric Brain Tumors Using Stimulated Raman Histology
Todd C. Hollon; Spencer Lewis; Balaji Pandian; Yashar S. Niknafs; Mia R. Garrard; Hugh Garton; Cormac O. Maher; Kathryn McFadden; Matija Snuderl; Andrew P. Lieberman; Karin Muraszko; Sandra Camelo-Piragua; Daniel A. Orringer
Convergence and Technologies
Population and Prevention Science
Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk
Hui Zuo; Per M. Ueland; Øivind Midttun; Stein E. Vollset; Grethe S. Tell; Despoina Theofylaktopoulou; Ruth C. Travis; Marie-Christine Boutron-Ruault; Agnès Fournier; Gianluca Severi; Marina Kvaskoff; Heiner Boeing; Manuela M. Bergmann; Renée T. Fortner; Rudolf Kaaks; Antonia Trichopoulou; Anastasia Kotanidou; Pagona Lagiou; Domenico Palli; Sabina Sieri; Salvatore Panico; H. Bas Bueno-de-Mesquita; Petra H. Peeters; Kjell Grankvist; Mikael Johansson; Antonio Agudo; Jose Ramon Quiros Garcia; Nerea Larranaga; Maria-Jose Sanchez; Maria Dolores Chirlaque; Eva Ardanaz; Shu-Chun Chuang; Valentina Gallo; Paul Brennan; Mattias Johansson; Arve Ulvik
Correction
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