Issues
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Kinases are master regulators of cell signaling networks that are frequently dysregulated in cancer, and members of the kinome family have been successfully targeted for therapeutic benefit. In this figure, the activity, cellular requirement, disease association, availability of protein structures and drugs, and research publications associated with each of the 535 members of the human protein kinome are displayed. It highlights how most research attention has been focused on relatively small subsets of the kinome. In the associated resource-based review, the authors discuss their current understanding of the human protein kinome, highlight emerging and overlooked areas, and describe key aspects of kinase signaling biology and some of the challenges associated with treating perturbed kinase networks in patients. For details, see article by Wilson and colleagues on page 15. - PDF Icon PDF LinkTable of Contents
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Cancer Research
Table of Contents
Breaking Insights
Editorial
Obituary
Reviews
Metabolism and Chemical Biology
Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Molecular Cell Biology
MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels
TGFβ Promotes Genomic Instability after Loss of RUNX3
Tumor Biology and Immunology
An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis
CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells
A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression
Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer
Translational Science
Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma
Rapid Intraoperative Diagnosis of Pediatric Brain Tumors Using Stimulated Raman Histology
Convergence and Technologies
Population and Prevention Science
Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk
Correction
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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