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Volume 77, Issue 6
15 March 2017
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    Many human tumors are characterized by extensive fibrin deposition in their extracellular matrix. Shown here is a representative image of a human colon tumor section stained for fibrin. For details, see article by Kirtane and colleagues on page 1465.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

Author Choice
Interplay between Immune Checkpoint Proteins and Cellular Metabolism
Sangbin Lim; Joshua B. Phillips; Luciana Madeira da Silva; Ming Zhou; Oystein Fodstad; Laurie B. Owen; Ming Tan
View articletitled, Interplay between Immune Checkpoint Proteins and Cellular Metabolism
Supplementary data
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Author Choice
Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice
Bernard Leroy; Mandy L. Ballinger; Fanny Baran-Marszak; Gareth L. Bond; Antony Braithwaite; Nicole Concin; Lawrence A. Donehower; Wafik S. El-Deiry; Pierre Fenaux; Gianluca Gaidano; Anita Langerød; Eva Hellstrom-Lindberg; Richard Iggo; Jacqueline Lehmann-Che; Phuong L. Mai; David Malkin; Ute M. Moll; Jeffrey N. Myers; Kim E. Nichols; Sarka Pospisilova; Patricia Ashton-Prolla; Davide Rossi; Sharon A. Savage; Louise C. Strong; Patricia N. Tonin; Robert Zeillinger; Thorsten Zenz; Joseph F. Fraumeni, Jr; Peter E.M. Taschner; Pierre Hainaut; Thierry Soussi
View articletitled, Recommended Guidelines for Validation, Quality Control, and Reporting of <em>TP53</em> Variants in Clinical Practice
Supplementary data
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Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
Peter Valent; Cem Akin; Karin Hartmann; Gunnar Nilsson; Andreas Reiter; Olivier Hermine; Karl Sotlar; Wolfgang R. Sperr; Luis Escribano; Tracy I. George; Hanneke C. Kluin-Nelemans; Celalettin Ustun; Massimo Triggiani; Knut Brockow; Jason Gotlib; Alberto Orfao; Lawrence B. Schwartz; Sigurd Broesby-Olsen; Carsten Bindslev-Jensen; Petri T. Kovanen; Stephen J. Galli; K. Frank Austen; Daniel A. Arber; Hans-Peter Horny; Michel Arock; Dean D. Metcalfe
View articletitled, Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future
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Integrated Systems and Technologies

Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment
Frederick S. Varn; Yue Wang; David W. Mullins; Steven Fiering; Chao Cheng
View articletitled, Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment
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Microenvironment and Immunology

Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3
Masahiro Hiasa; Tatsuo Okui; Yohance M. Allette; Matthew S. Ripsch; Ge-Hong Sun-Wada; Hiroki Wakabayashi; G. David Roodman; Fletcher A. White; Toshiyuki Yoneda
View articletitled, Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3
Supplementary data
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Author Choice
A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells
Sherly Mardiana; Liza B. John; Melissa A. Henderson; Clare Y. Slaney; Bianca von Scheidt; Lauren Giuffrida; Alexander J. Davenport; Joseph A. Trapani; Paul J. Neeson; Sherene Loi; Nicole M. Haynes; Michael H. Kershaw; Paul A. Beavis; Phillip K. Darcy
View articletitled, A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells
Supplementary data
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Radiation-Induced Enhancement of Antitumor T-cell Immunity by VEGF-Targeted 4-1BB Costimulation
Brett Schrand; Bhavna Verma; Agata Levay; Shradha Patel; Iris Castro; Ana Paula Benaduce; Randall Brenneman; Oliver Umland; Hideo Yagita; Eli Gilboa; Adrian Ishkanian
View articletitled, Radiation-Induced Enhancement of Antitumor T-cell Immunity by VEGF-Targeted 4-1BB Costimulation
Supplementary data
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Author Choice
Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire
David Y. Oh; Jason Cham; Li Zhang; Grant Fong; Serena S. Kwek; Mark Klinger; Malek Faham; Lawrence Fong
View articletitled, Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire
Supplementary data
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Molecular and Cellular Pathobiology

Author Choice
Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis
Srinivas Nandana; Manisha Tripathi; Peng Duan; Chia-Yi Chu; Rajeev Mishra; Chunyan Liu; Renjie Jin; Hironobu Yamashita; Majd Zayzafoon; Neil A. Bhowmick; Haiyen E. Zhau; Robert J. Matusik; Leland W.K. Chung
View articletitled, Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis
Supplementary data
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RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Xiaowei Wei; Yong Xu; Fang Fang Xu; Luksana Chaiswing; David Schnell; Teresa Noel; Chi Wang; Jinfei Chen; Daret K. St. Clair; William H. St. Clair
View articletitled, RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplementary data
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A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer
Cristian Suárez-Cabrera; Rita M. Quintana; Ana Bravo; M. Llanos Casanova; Angustias Page; Josefa P. Alameda; Jesús M. Paramio; Alicia Maroto; Javier Salamanca; Adam J. Dupuy; Angel Ramírez; Manuel Navarro
View articletitled, A Transposon-based Analysis Reveals <em>RASA1</em> Is Involved in Triple-Negative Breast Cancer
Supplementary data
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Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer
Linjie Zhao; Gaili Ji; Xiaobing Le; Chenlu Wang; Lian Xu; Min Feng; Yaguang Zhang; Huiliang Yang; Yu Xuan; Yanfei Yang; Lingzi Lei; Qilian Yang; Wayne Bond Lau; Bonnie Lau; Yi Chen; Xiangbing Deng; Shaohua Yao; Tao Yi; Xia Zhao; Yuquan Wei; Shengtao Zhou
View articletitled, Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer
Supplementary data
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Author Choice
Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x–SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis
Yong Wu; Xiaoting Yu; Xianghua Yi; Ke Wu; Sami Dwabe; Mohammad Atefi; Yahya Elshimali; Kevin T. Kemp, II; Kruttika Bhat; Jesse Haro; Marianna Sarkissyan; Jaydutt V. Vadgama
View articletitled, Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x–SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis
Supplementary data
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Tumor-Associated Neutrophils and Macrophages Promote Gender Disparity in Hepatocellular Carcinoma in Zebrafish
Chuan Yan; Qiqi Yang; Zhiyuan Gong
View articletitled, Tumor-Associated Neutrophils and Macrophages Promote Gender Disparity in Hepatocellular Carcinoma in Zebrafish
Supplementary data
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Prevention and Epidemiology

Author Choice
Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis
Florentin Späth; Carl Wibom; Esmeralda J.M. Krop; Ann-Sofie Johansson; Ingvar A. Bergdahl; Roel Vermeulen; Beatrice Melin
View articletitled, Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis
Supplementary data
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Therapeutics, Targets, and Chemical Biology

Author Choice
Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4
Stacey A. Ward; Nicole M. Warrington; Sara Taylor; Najla Kfoury; Jingqin Luo; Joshua B. Rubin
View articletitled, Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4
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Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells
Ong Nam Phuong Nguyen; Christian Grimm; Lina S. Schneider; Yu-Kai Chao; Carina Atzberger; Karin Bartel; Anna Watermann; Melanie Ulrich; Doris Mayr; Christian Wahl-Schott; Martin Biel; Angelika M. Vollmar
View articletitled, Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells
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Author Choice
Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers
Lisa Choy; Thijs J. Hagenbeek; Margaret Solon; Dorothy French; David Finkle; Amy Shelton; Rayna Venook; Matthew J. Brauer; Christian W. Siebel
View articletitled, Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers
Supplementary data
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Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells
Yoko Tabe; Shinichi Yamamoto; Kaori Saitoh; Kazumasa Sekihara; Norikazu Monma; Kazuho Ikeo; Kaoru Mogushi; Masato Shikami; Vivian Ruvolo; Jo Ishizawa; Numsen Hail, Jr; Saiko Kazuno; Mamoru Igarashi; Hiromichi Matsushita; Yasunari Yamanaka; Hajime Arai; Isao Nagaoka; Takashi Miida; Yoshihide Hayashizaki; Marina Konopleva; Michael Andreeff
View articletitled, Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells
Supplementary data
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Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine
Ameya R. Kirtane; Tanmoy Sadhukha; Hyunjoon Kim; Vidhi Khanna; Brenda Koniar; Jayanth Panyam
View articletitled, Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine
Supplementary data
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[18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition
Rong Zhou; Austin R. Pantel; Shihong Li; Brian P. Lieberman; Karl Ploessl; Hoon Choi; Eric Blankemeyer; Hsiaoju Lee; Hank F. Kung; Robert H. Mach; David A. Mankoff
View articletitled, [<sup>18</sup>F](2<em>S</em>,4<em>R</em>)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition
Supplementary data
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Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination
Bregje van Oorschot; Lon Uitterhoeve; Ilja Oomen; Rosemarie ten Cate; Jan Paul Medema; Harry Vrieling; Lukas J.A. Stalpers; Perry D. Moerland; Nicolaas A.P. Franken
View articletitled, Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination
Supplementary data
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Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation
Ye Cui; Wendy K. Steagall; Anthony M. Lamattina; Gustavo Pacheco-Rodriguez; Mario Stylianou; Pranav Kidambi; Benjamin Stump; Fernanda Golzarri; Ivan O. Rosas; Carmen Priolo; Elizabeth P. Henske; Joel Moss; Souheil El-Chemaly
View articletitled, Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation
Supplementary data
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Corrections

Correction: Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer
View articletitled, Correction: Long Noncoding RNA <em>GCASPC</em>, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer
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Correction: Cdk5 Directly Targets Nuclear p21CIP1 and Promotes Cancer Cell Growth
View articletitled, Correction: Cdk5 Directly Targets Nuclear p21<sup>CIP1</sup> and Promotes Cancer Cell Growth
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Correction: Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E
View articletitled, Correction: Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E
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