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15 December 2017
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Mitochondrial polymorphisms are associated with defining human clades (races) and with susceptibility to mammary tumor development and metastasis. Brinker and colleagues show that metastatic efficiency changes with different mitochondrial haplotypes in an oncogenic driver-dependent manner. Vimentin is a marker of an epithelial-mesenchymal transition, a process that is often associated with tumor invasion and metastasis. Unexpectedly, no effect on vimentin immunohistochemical staining was observed in HER2-driven mammary tumors despite changes in metastatic efficiency. For details, see article by Brinker and colleagues on page 6941.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Priority Report
Molecular and Cellular Pathobiology
SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells
Xiaoliang L. Xu; Zhengke Li; Aihong Liu; Xianqun Fan; Dan-ning Hu; Dong-Lai Qi; David W. Chitty; Renbing Jia; Jianping Qui; Justin Q. Wang; Jake Sharaf; Jun Zou; Rebecca Weiss; Hongyan Huang; Walter J. Joseph; Lily Ng; Richard Rosen; Binghui Shen; Mark W. Reid; Douglas Forrest; David H. Abramson; Samuel Singer; David Cobrinik; Suresh C. Jhanwar
Tumor and Stem Cell Biology
NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem–like Cells
Carrie D. House; Elizabeth Jordan; Lidia Hernandez; Michelle Ozaki; Jana M. James; Marianne Kim; Michael J. Kruhlak; Eric Batchelor; Fathi Elloumi; Margaret C. Cam; Christina M. Annunziata
Therapeutics, Targets, and Chemical Biology
Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression
Sungjin Kim; Omar Awad Alsaidan; Octavia Goodwin; Qianjin Li; Essilvo Sulejmani; Zhen Han; Aiping Bai; Thomas Albers; Zanna Beharry; Y. George Zheng; James S. Norris; Zdzislaw M. Szulc; Alicja Bielawska; Iryna Lebedyeva; Scott D. Pegan; Houjian Cai
Author Choice
New Generation Nanomedicines Constructed from Self-Assembling Small-Molecule Prodrugs Alleviate Cancer Drug Toxicity
Hangxiang Wang; Zhongjie Lu; Lijiang Wang; Tingting Guo; Jiaping Wu; Jianqin Wan; Liqian Zhou; Hui Li; Zhen Li; Donghai Jiang; Penghong Song; Haiyang Xie; Lin Zhou; Xiao Xu; Shusen Zheng
SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma
Takahito Sugase; Tsuyoshi Takahashi; Satoshi Serada; Minoru Fujimoto; Kosuke Hiramatsu; Tomoharu Ohkawara; Koji Tanaka; Yasuhiro Miyazaki; Tomoki Makino; Yukinori Kurokawa; Makoto Yamasaki; Kiyokazu Nakajima; Tadamitsu Kishimoto; Masaki Mori; Yuichiro Doki; Tetsuji Naka
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma
Jaya Julie Joshi; Heather Coffey; Erik Corcoran; Jennifer Tsai; Chia-Ling Huang; Kana Ichikawa; Sudeep Prajapati; Ming-Hong Hao; Suzanna Bailey; Jeremy Wu; Victoria Rimkunas; Craig Karr; Vanitha Subramanian; Pavan Kumar; Crystal MacKenzie; Raelene Hurley; Takashi Satoh; Kun Yu; Eunice Park; Nathalie Rioux; Amy Kim; Weidong G. Lai; Lihua Yu; Ping Zhu; Silvia Buonamici; Nicholas Larsen; Peter Fekkes; John Wang; Markus Warmuth; Dominic J. Reynolds; Peter G. Smith; Anand Selvaraj
Author Choice
ATR Is a Therapeutic Target in Synovial Sarcoma
Samuel E. Jones; Emmy D.G. Fleuren; Jessica Frankum; Asha Konde; Chris T. Williamson; Dragomir B. Krastev; Helen N. Pemberton; James Campbell; Aditi Gulati; Richard Elliott; Malini Menon; Joanna L. Selfe; Rachel Brough; Stephen J. Pettitt; Wojciech Niedzwiedz; Winette T.A. van der Graaf; Janet Shipley; Alan Ashworth; Christopher J. Lord
Author Choice
Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates
Niña G. Caculitan; Josefa dela Cruz Chuh; Yong Ma; Donglu Zhang; Katherine R. Kozak; Yichin Liu; Thomas H. Pillow; Jack Sadowsky; Tommy K. Cheung; Qui Phung; Benjamin Haley; Byoung-Chul Lee; Robert W. Akita; Mark X. Sliwkowski; Andrew G. Polson
MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia
Nakhle S. Saba; Deanna H. Wong; Georges Tanios; Jessica R. Iyer; Patricia Lobelle-Rich; Eman L. Dadashian; Delong Liu; Lorena Fontan; Erik K. Flemington; Cydney M. Nichols; Chingiz Underbayev; Hana Safah; Ari Melnick; Adrian Wiestner; Sarah E. M. Herman
Microenvironment and Immunology
Integrated Systems and Technologies
Letter to the Editor
Correction
Acknowledgment to Reviewers
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